Programmed Death Ligand 2 in Cancer-Induced Immune Suppression

PD-1 and Its Ligands in Tolerance and Immunity

2008 • 4,838 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

2010 • 2,721 citations

CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

2005 • 1,746 citations

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

2010 • 1,711 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Inhibitory B7-family molecules in the tumour microenvironment

2008 • 1,511 citations

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺T lymphocytes are prognostic factors of human ovarian cancer

2007 • 1,317 citations

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

2012 • 1,274 citations

PD-1 and PD-1 ligands: from discovery to clinical application

2007 • 1,199 citations

Tissue expression of PD-L1 mediates peripheral T cell tolerance

2006 • 1,145 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

2007 • 843 citations

Tumor B7-H1 Is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up

2006 • 826 citations

Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

2009 • 770 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

PD‐1 signaling in primary T cells

2009 • 712 citations

Immunotherapy and chemotherapy — a practical partnership

2005 • 639 citations

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

2011 • 618 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

2003 • 584 citations

Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-γ and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway

2007 • 553 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

2008 • 485 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

2012 • 424 citations

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

2008 • 402 citations

Cancer immunotherapy – revisited

2011 • 399 citations

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

2009 • 380 citations

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

2006 • 357 citations

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

2011 • 350 citations

The role of the PD‐1 pathway in autoimmunity and peripheral tolerance

2011 • 329 citations

Tissue-based class control: the other side of tolerance

2011 • 326 citations

Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development

2007 • 316 citations

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

2011 • 310 citations

Signaling mechanisms, interaction partners, and target genes of STAT6

2006 • 287 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells

2007 • 239 citations

T-cell tolerance or function is determined by combinatorial costimulatory signals

2006 • 229 citations

Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

2011 • 217 citations

PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1

2010 • 206 citations

Differential binding properties of B7-H1 and B7-DC to programmed death-1

2003 • 198 citations

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

2008 • 190 citations

PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells

2009 • 188 citations

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2

2010 • 182 citations

PD‐L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V_H11/V_H12 and phosphatidylcholine binding

2007 • 174 citations

PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions

2009 • 169 citations

Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation

2003 • 168 citations

PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity

2008 • 162 citations

Regulation of T cell activation and tolerance by PDL2

2006 • 159 citations

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

2005 • 152 citations

Yin–Yang of costimulation: crucial controls of immune tolerance and function

2009 • 145 citations

Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of Combination Immunotherapy against Melanoma

2010 • 145 citations

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen–specific CD8+ T cells

2010 • 139 citations

B7-DC Regulates Asthmatic Response by an IFN-γ-Dependent Mechanism

2004 • 135 citations

Distinct Signal Codes Generate Dendritic Cell Functional Plasticity

2010 • 126 citations

A Novel Role for Interleukin-27 (IL-27) as Mediator of Intestinal Epithelial Barrier Protection Mediated via Differential Signal Transducer and Activator of Transcription (STAT) Protein Signaling and Induction of Antibacterial and Anti-inflammatory Proteins

2011 • 125 citations

Blocking Programmed Death-1 Ligand-PD-1 Interactions by Local Gene Therapy Results in Enhancement of Antitumor Effect of Secondary Lymphoid Tissue Chemokine

2004 • 122 citations

Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis

2006 • 115 citations

Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model

2009 • 113 citations

PD-L2 is expressed on activated human T cells and regulates their function

2011 • 108 citations

Expression of Programmed Death–1 Ligand (PD‐L) 1, PD‐L2, B7‐H3, and Inducible Costimulator Ligand on Human Respiratory Tract Epithelial Cells and Regulation by Respiratory Syncytial Virus and Type 1 and 2 Cytokines

2006 • 96 citations

siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions

2011 • 61 citations

No evidence for dualism in function and receptors: PD‐L2/B7‐DC is an inhibitory regulator of human T cell activation

2006 • 49 citations

Costimulator B7-DC Attenuates Strong Th2 Responses Induced by Nippostrongylus brasiliensis

2010 • 37 citations

STATing the importance of immune modulation by platinum chemotherapeutics

2012 • 34 citations

IL-4-stimulated NF-κB activity is required for Stat6 DNA binding

2007 • 27 citations

A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer

2003 • 13 citations