Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

PD-1 and PD-1 ligands: from discovery to clinical application

2007 • 1,199 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

Costimulation Blockade with Belatacept in Renal Transplantation

2005 • 833 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

Rational Development of LEA29Y (belatacept), a High-Affinity Variant of CTLA4-Ig with Potent Immunosuppressive Properties

2005 • 683 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

2001 • 459 citations

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

2008 • 402 citations

Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1

2004 • 365 citations

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

2001 • 333 citations

The B7 Family and Cancer Therapy: Costimulation and Coinhibition

2007 • 326 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

Structure and Dimerization of a Soluble Form of B7-1

2000 • 240 citations

Differential binding properties of B7-H1 and B7-DC to programmed death-1

2003 • 198 citations

Crystal structure of a soluble CD28-Fab complex

2005 • 161 citations

Structure of Murine CTLA-4 and Its Role in Modulating T Cell Responsiveness

2000 • 144 citations

Structural mechanisms of costimulation

2002 • 129 citations

Different cell surface oligomeric states of B7-1 and B7-2: Implications for signaling

2005 • 105 citations

Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability

2007 • 105 citations

Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1

2004 • 45 citations