PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Local control of the immune response in the liver

2000 • 593 citations

BLC Expression in Pancreatic Islets Causes B Cell Recruitment and Lymphotoxin-Dependent Lymphoid Neogenesis

2000 • 450 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8⁺ T cell activation and cytolysis

2003 • 436 citations

The MHC class I antigen presentation pathway: strategies for viral immune evasion

2003 • 433 citations

Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines

1996 • 408 citations

T Cells with a CD4⁺CD25⁺Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8⁺T Cells during Chronic Hepatitis C Virus Infection

2005 • 403 citations

B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes

2004 • 375 citations

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

2003 • 373 citations

B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

2002 • 313 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

Inhibition of T–Cell Responses by Hepatic Stellate Cells Via B7–H1-Mediated T–Cell Apoptosis in Mice

2004 • 284 citations

The function of type I interferons in antimicrobial immunity

2000 • 277 citations

Program Death-1 Engagement Upon TCR Activation Has Distinct Effects on Costimulation and Cytokine-Driven Proliferation: Attenuation of ICOS, IL-4, and IL-21, But Not CD28, IL-7, and IL-15 Responses

2003 • 272 citations

Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts.

1997 • 272 citations

Viral immune evasion: a masterpiece of evolution

2002 • 248 citations

Cell-Mediated Immunity and the Outcome of Hepatitis C Virus Infection

2004 • 195 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells

2001 • 158 citations

Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells

1996 • 154 citations

B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism

2003 • 141 citations

Reversibility of hepatitis C virus-related cirrhosis

2004 • 135 citations

Dual Role of the IL-12/IFN-γ Axis in the Development of Autoimmune Myocarditis: Induction by IL-12 and Protection by IFN-γ

2001 • 134 citations

IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells

2005 • 111 citations

Differential induction of adhesion molecule and chemokine expression by LTalpha3 and LTalphabeta in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development.

1999 • 79 citations

Activated Hepatic Stellate Cells Express Keratinocyte Growth Factor in Chronic Liver Disease

2004 • 73 citations

The balance of immune responses: costimulation verse coinhibition

2005 • 71 citations

The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role

2004 • 70 citations

Differential Induction of Adhesion Molecule and Chemokine Expression by LTα3 and LTαβ in Inflammation Elucidates Potential Mechanisms of Mesenteric and Peripheral Lymph Node Development

1999 • 68 citations

Management of hepatitis C: current and future perspectives

1999 • 56 citations

CD4 T-Cell-Mediated Demyelination Is Increased in the Absence of Gamma Interferon in Mice Infected with Mouse Hepatitis Virus

2002 • 54 citations

Induction of tolerance to autoimmune diabetes with islet antigens.

1992 • 48 citations

The expression of IL-2, IL-4 and interferon-gamma (IFN-γ) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B

1995 • 39 citations

Mature But Not Immature Fas Ligand (CD95L)-Transduced Human Monocyte-Derived Dendritic Cells Are Protected from Fas-Mediated Apoptosis and Can Be Used as Killer APC

2003 • 36 citations

Accessory cell function of airway epithelial cells

2004 • 35 citations

Intrahepatic mRNA levels of interferon gamma and tumor necrosis factor alpha and response to antiviral treatment of chronic hepatitis C.

2001 • 34 citations

Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA

2005 • 34 citations

Fludrocortisone in the treatment of subarachnoid hemorrhage-induced hyponatremia.

1997 • 25 citations

Probing the mechanism of TNF-α(cachectin)- and TNF-β(lymphotoxin)-induced pancreatic inflammation with transgenic mice

1993 • 5 citations