Purinergic Signalling: Pathophysiological Roles

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1

1929 • 1,470 citations

European stroke prevention study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.

1997 • 1,389 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Purinoceptors: Are there families of P2X and P2Y purinoceptors?

1994 • 1,079 citations

Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow

1963 • 1,015 citations

A P2X purinoceptor expressed by a subset of sensory neurons

1995 • 1,014 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

1970 • 671 citations

Do some nerve cells release more than one transmitter?

1976 • 633 citations

Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission

1992 • 599 citations

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

1997 • 548 citations

The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves

1959 • 498 citations

Astroglia in CNS injury

1991 • 496 citations

Distinct ATP receptors on pain-sensing and stretch-sensing neurons

1997 • 452 citations

Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells

1996 • 447 citations

Signalling via ATP in the nervous system

1994 • 441 citations

Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes

1992 • 412 citations

Cell cycle and apoptosis: Common pathways to life and death

1995 • 404 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

Dipyridamole

1987 • 397 citations

ATP excites a subpopulation of rat dorsal horn neurones

1983 • 389 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

1981 • 380 citations

NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

1992 • 378 citations

The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death

1995 • 378 citations

Further subclassification of ATP receptors based on agonist studies

1991 • 374 citations

Purinergic receptors: their role in nociception and primary afferent neurotransmission

1996 • 356 citations

Towards a revised nomenclature for P1 and P2 receptors

1997 • 347 citations

Extracellular ATP as a trigger for apoptosis or programmed cell death.

1991 • 342 citations

Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts.

1988 • 332 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 319 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 305 citations

Functional studies of cotransmission.

1991 • 302 citations

The inhibitory innervation of the taenia of the guinea‐pig caecum

1966 • 293 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.

1992 • 284 citations

ATP P_2XReceptors Mediate Fast Synaptic Transmission in the Dorsal Horn of the Rat Spinal Cord

1997 • 264 citations

G protein-coupled receptors for ATP and other nucleotides: a new receptor family

1994 • 252 citations

The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role.

1995 • 251 citations

Role of adenosine in pathogenesis of anginal pain.

1990 • 245 citations

A unifying purinergic hypothesis for the initiation of pain

1996 • 241 citations

Purinergic approaches in experimental therapeutics

1997 • 238 citations

The effect of long-term vasodilatation on capillary growth and performance in rabbit heart and skeletal muscle

1984 • 207 citations

Signal Transduction by P₂-Purinergic Receptors for Extracellular ATP

1991 • 193 citations

Purinergic receptors

1976 • 185 citations

Responses of mouse lymphocytes to extracellular adenosine 5'-triphosphate (ATP). Lymphocytes with cytotoxic activity are resistant to the permeabilizing effects of ATP.

1989 • 178 citations

Regulation of Inducible Nitric Oxide Synthase Expression by Macrophage Purinoreceptors and Calcium

1996 • 175 citations

Cationic channels activated by extracellular atp in rat sensory neurons

1988 • 174 citations

Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain

1993 • 173 citations

The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease

1993 • 169 citations

Electrophysiological behavior of microglia

1993 • 167 citations

ATP-induced cytoplasmic calcium mobilization in Bergmann glial cells

1995 • 166 citations

P2 purinoceptors on vascular endotheliai cells: physiological significance and transduction mechanisms

1990 • 160 citations

On the composition and function of large dense cored vesicles in sympathetic nerves

1976 • 160 citations

Activation of P2‐purinoreceptors triggered Ca2+ release from InsP3‐sensitive internal stores in mammalian oligodendrocytes.

1995 • 153 citations

Extracellular ATP is a mitogen for 3T3, 3T6, and A431 cells and acts synergistically with other growth factors.

1989 • 149 citations

Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn

1993 • 148 citations

Numbering of cloned P2 purinoceptors

1996 • 148 citations

P2 Purinoceptors: Historical Perspective and Classification

2007 • 147 citations

Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum

1994 • 143 citations

Noradrenaline and ATP: cotransmitters and neuromodulators.

1995 • 141 citations

Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cells

1992 • 140 citations

Effect of exogenous ATP on the permeability properties of transformed cultures of mouse cell lines.

1977 • 140 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

ATP-Stimulated Release of ATP by Human Endothelial Cells

1996 • 136 citations

Full sensitivity of P_2times2 purinoceptor to ATP revealed by changing extracellular pH

1996 • 136 citations

Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells

1996 • 134 citations

Treatment of human tumor cells with ADP or ATP yields arrest of growth in the S phase of the cell cycle

1983 • 133 citations

Astrocytes: Pharmacology and Function

1994 • 131 citations

Early Expression of a Novel Nucleotide Receptor in the Neural Plate of Xenopus Embryos

1997 • 131 citations

Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

1995 • 129 citations

Neurochemical analysis of focal ischemia in rats.

1991 • 125 citations

Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity

1992 • 121 citations

Extracellular ATP as a possible mediator of cell-mediated cytotoxicity

1990 • 120 citations

Characterization of P2‐purinoceptors in the smooth muscle of the rat tail artery: a comparison between contractile and electrophysiological responses

1994 • 118 citations

Purinoceptors: Ontogeny and phylogeny

1996 • 117 citations

Adenosine A_2b Receptors Mediate an Increase in Interleukin (IL)‐6 mRNA and IL‐6 Protein Synthesis in Human Astroglioma Cells

1996 • 115 citations

Hypoxia-induced angiogenesis in chick chorioallantoic membranes: a role for adenosine

1988 • 111 citations

A Novel Extracellular Nucleotide Receptor Coupled to Phosphoinositidase-C in Pituitary Cells*

1990 • 110 citations

Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astrocyte cultures

1994 • 110 citations

Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells

1995 • 108 citations

Synergistic Activation of DNA Synthesis in Astrocytes by Fibroblast Growth Factors and Extracellular ATP

1994 • 107 citations

ATP modulation of calcium channels in chromaffin cells.

1993 • 104 citations

Dual Control of Local Blood Flow by Purines^a

1990 • 104 citations

Myocardial adenosine salvage rates and restoration of ATP content following ischemia

1979 • 103 citations

Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts

1995 • 102 citations

Extracellular ATP causes loss of L-selectin from human lymphocytes via occupancy of P2Z purinoceptors

1996 • 101 citations

Propagation of Mechanically Induced Intercellular Calcium Waves via Gap Junctions and ATP Receptors in Rat Liver Epithelial Cells

1997 • 99 citations

Colocalization of nitric oxide synthase and NADPH-diaphorase in cultured myenteric neurons

1992 • 98 citations

Characterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages

1992 • 98 citations

Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine

1995 • 98 citations

Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis.

1986 • 98 citations

P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.

1992 • 97 citations

The biological actions of extracellular ATP

1989 • 96 citations

Extracellular ATP shows synergistic enhancement of DNA synthesis when combined with agents that are active in wound healing or as neurotransmitters

1990 • 95 citations

Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters

1993 • 93 citations

Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats

1994 • 92 citations

Permeabilization of transformed cells in culture by external ATP

1985 • 92 citations

The Action of Adenosine Analogs on PC12 Cells

1981 • 91 citations

Signaling by ATP receptors in astrocytes

1994 • 91 citations

Purinoceptor nomenclature: A status report

1993 • 91 citations

Extracellular ATP is a trigger for the acrosome reaction in human spermatozoa.

1992 • 89 citations

Extracellular purine nucleosides stimulate cell division and morphogenesis: Pathological and physiological implications

1992 • 88 citations

Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes

1994 • 87 citations

Extracellular ATP activates receptor‐operated cation channels in mouse lacrimal acinar cells to promote calcium influx in the absence of phosphoinositide metabolism

1990 • 86 citations

Release of noradrenaline and ATP by electrical stimulation and nicotine in guinea-pig vas deferens

1991 • 86 citations

Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes

1997 • 86 citations

ATP activates a cation-permeable pathway in rat parotid acinar cells

1992 • 86 citations

Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor‐induced astrogliosis

1997 • 86 citations

Extracellular nucleotides elevate [Ca2+]i in rat osteoblastic cells by interaction with two receptor subtypes

1992 • 86 citations

The P2 Nucleotide Receptors

1998 • 85 citations

P2U Agonists Induce Chemotaxis and Actin Polymerization in Human Neutrophils and Differentiated HL60 Cells

1996 • 83 citations

Renal periarterial nerve stimulation-induced vasoconstriction at low frequencies is primarily due to release of a purinergic transmitter in the rat.

1989 • 81 citations

GTP and guanosine synergistically enhance NGF‐induced neurite outgrowth from PC12 cells

1996 • 81 citations

Modulation of Apoptosis by Adenosine in the Central Nervous System: a Possible Role for the A₃ Receptor

1997 • 81 citations

Excitation of single sensory neurones in the rat caudal trigeminal nucleus by iontophoretically applied adenosine 5′-triphosphate

1983 • 80 citations

AUTONOMIC NEUROEFFECTOR JUNCTIONS—REFLEX VASODILATATION OF THE SKIN

1977 • 80 citations

Calcitonin gene‐related peptide and ATP induce immediate early gene expression in cultured rat microglial cells

1995 • 79 citations

Adenosine‐induced apoptosis in chick embryonic sympathetic neurons: a new physiological role for adenosine.

1995 • 78 citations

Adenosine stimulates DNA fragmentation in human thymocytes by Ca2+-mediated mechanisms

1994 • 77 citations

Ca2+ responses to ATP via purinoceptors in the early embryonic chick retina.

1996 • 77 citations

PATHOPHYSIOLOGY OF MIGRAINE: A NEW HYPOTHESIS

1981 • 77 citations

Characterization of P₁‐purinoceptors on rat duodenum and urinary bladder

1992 • 77 citations

Growth inhibition of human tumor cells in soft-agar cultures by treatment with low levels of adenosine 5'-triphosphate.

1983 • 76 citations

Angiotensin neuromodulation of adrenergic and purinergic co‐transmission in the guinea‐pig vas deferens

1989 • 76 citations

P2X purinoceptor plethora

1996 • 76 citations

Rac is required for growth cone function but not neurite assembly

1997 • 75 citations

Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells

1992 • 74 citations

Role of the Purinergic P2Z Receptor in Spontaneous Cell Death in J774 Macrophage Cultures

1996 • 72 citations

Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine.

1988 • 72 citations

Adenosine receptor activation in quiescent Swiss 3T3 cells

1982 • 71 citations

Experimental cancer therapy in mice by adenine nucleotides

1988 • 68 citations

Ca²⁺‐stores mobilization by diadenosine tetraphosphate, Ap₄A, through a putative P_2Y purinoceptor in adrenal chromaffin cells

1992 • 68 citations

Multiple actions of extracellular ATP on calcium currents in cultured bovine chromaffin cells.

1991 • 68 citations

Activation of inositol phospholipid turnover and calcium signaling in rat Sertoli cells by P2-purinergic receptors: modulation of follicle-stimulating hormone responses.

1994 • 65 citations

Role of P2z purinergic receptors in ATP-mediated killing of tumor necrosis factor (TNF)-sensitive and TNF-resistant L929 fibroblasts.

1992 • 64 citations

Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms

1996 • 64 citations

Potentiation of ATP‐responses at a recombinant P_2X2 receptor by neurotransmitters and related substances

1997 • 64 citations

Evidence for P2-purinoceptors on human osteoblast-like cells

1992 • 64 citations

A Wave in the Earth

1996 • 62 citations

Quinacrine fluorescence of Merkel cells in Xenopus laevis

1978 • 62 citations

Extracellular guanosine and guanosine-5′-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes

1995 • 61 citations

Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase

1992 • 60 citations

Blockade of vasopressor and vas deferens responses by α, β‐methylene ATP in the pithed rat

1988 • 59 citations

Characterization and transduction mechanisms of purinoceptors in activated rat microglia

1994 • 59 citations

Exogenous ATP induces a limited cell cycle progression of arterial smooth muscle cells

1993 • 59 citations

CELLULAR BIOLOGY OF BONE RESORPTION

1993 • 58 citations

Chapter 12: Signaling by extracellular ATP: physiological and pathological considerations in neuronal-astrocytic interactions

1992 • 58 citations

Effects of ATP analogues and basic fibroblast growth factor on astroglial cell differentiation in primary cultures of rat striatum

1995 • 58 citations

Purinergic stimulation of astroblast proliferation: Guanosine and its nucleotides stimulate cell division in chick astroblasts

1991 • 58 citations

P1 and P2 receptors in cell growth and differentiation

1996 • 58 citations

Elevated NMDA receptors in Parkinsonian striatum

1992 • 57 citations

Effect of Adenosine Receptor Agonists and Antagonists on the Expression of Opiate Withdrawal in Rats

1997 • 57 citations

Protection of mice from endotoxic death by 2-methylthio-ATP.

1994 • 56 citations

Purinergic agonist ATP is a comitogen in thyroid FRTL-5 cells

1996 • 56 citations

Non‐synaptic Release of ATP by Electrical Stimulation in Slices of Rat Hippocampus, Cerebellum and Habenula

1996 • 55 citations

Different pathways of apoptosis revealed by 2-chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells

1997 • 54 citations

Adenosine receptors and modulation of natural killer cell activity by purine nucleosides.

1990 • 54 citations

Prior heat stress enhances survival of renal epithelial cells after ATP depletion

1996 • 53 citations

Diadenosine polyphosphate (Ap_xA) as new neurotransmitters

1993 • 53 citations

Extracellular guanosine increases astrocyte cAMP

1991 • 52 citations

Neurotransmitter regulation of cytosolic calcium in osteoblast-like bone cells

1989 • 51 citations

EVIDENCE THAT ADENOSINE IS A KEY COMPONENT IN CAROLINA RINSE RESPONSIBLE FOR REDUCING GRAFT FAILURE AFTER ORTHOTOPIC LIVER TRANSPLANTATION IN THE RAT

1991 • 51 citations

Development and perspectives of the purinoceptor concept

1996 • 50 citations

Adenine nucleotide metabolism by chondrocytes in vitro: Role of ATP in chondrocyte maturation and matrix mineralization

1995 • 50 citations

Cytosolic Ca2+ transients are not required for platelet-derived growth factor to induce cell cycle progression of vascular smooth muscle cells in primary culture. Actions of tyrosine kinase.

1994 • 50 citations

Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture

1991 • 49 citations

Elevation of Extracellular Adenosine Induces Radioprotective Effects in Mice

1993 • 48 citations

ATP, α,β‐methylene ATP and suramin as tools for characterization of vascular P_2X receptors in the pithed rat

1989 • 47 citations

Extracellular ATP increases intracellular calcium in cultured adult Schwann cells

1996 • 46 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

Purinoceptor function in the immune system

1996 • 46 citations

Permeabilization of cells of hemopoietic origin by extracellular ATP4-: Elimination of osteoclasts, macrophages, and their precursors from isolated bone cell populations and fetal bone rudiments

1994 • 46 citations

VI. Nomenclature and Classification of Purinoceptors

1994 • 46 citations

Generation of extracellular atp in blood and its mediated inhibition of host weight loss in tumor-bearing mice

1989 • 45 citations

Trophic Actions of Extracellular ATP on Astrocytes, Synergistic Interactions with Fibroblast Growth Factors and Underlying Signal Transduction Mechanisms

2007 • 45 citations

Anti-inflammatory effects of adenosine kinase inhibitors in acute and chronic inflammation

1996 • 44 citations

Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters

1993 • 44 citations

Trophic actions of 2-chloroadenosine and bFGF on cultured myenteric neurones

1995 • 44 citations

European Stroke Prevention Study-2 results: serendipitous demonstration of neuroprotection induced by endogenous adenosine accumulation?

1998 • 44 citations

Osteoblast‐like cells have a variable mixed population of purino/nucleotide receptors

1993 • 43 citations

Nitric oxide synthase in neurons of the human gall‐bladder and its colocalization with neuropeptides

1997 • 43 citations

Modulation of neurotransmission in the guinea‐pig vas deferens by capsaicin: involvement of calcitonin gene‐related peptide and substance P

1989 • 43 citations

A Putative ATP-Activated Na ⁺ Channel Involved in Sperm-Induced Fertilization

1993 • 42 citations

Effect of P_2Y Agonists on Adenosine Transport in Cultured Chromaffin Cells

1993 • 42 citations

Chronic oral dipyridamole as a ?novel? antianginal drug: the collateral hypothesis

1997 • 42 citations

Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells.

1996 • 41 citations

Human tumor tissues have higher ATP contents than normal tissues

1987 • 39 citations

Precocious evagination of the embryonic chick thyroid in ATP-containing medium

1977 • 39 citations

Changes in Responsiveness to Extracellular ATP in Chick Skeletal Muscle during Development and upon Denervation

1995 • 39 citations

Cationic channels sensitive to extracellular ATP in rat lacrimal cells.

1992 • 39 citations

ATP Receptor-Operated Ca2+ Influx and Catecholamine Release From Neuronal Cells

1992 • 39 citations

Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine

1992 • 37 citations

Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: Modulation during cell differentiation

1989 • 37 citations

Introduction: Purinergic transmission

1996 • 37 citations

Ca2+-mobilizing receptors of gastrulating chick embryo

1990 • 37 citations

Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes

1992 • 36 citations

Nonadrenergic and noncholinergic excitatory neurotransmission in rat intrapulmonary artery

1988 • 36 citations

Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron

1996 • 35 citations

Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors

1998 • 35 citations

Effects of extracellular nucleotides in the pituitary: adenosine triphosphate receptor-mediated intracellular responses in gonadotrope-derived alpha T3-1 cells.

1996 • 35 citations

Angiotensin effects on vas deferens adrenergic and purinergic neurotransmission

1988 • 35 citations

Osteoclast ATP receptor activation leads to a transient decrease in intracellular pH

1995 • 34 citations

Heat stress ameliorates ATP depletion-induced sublethal injury in mouse proximal tubule cells

1997 • 34 citations

Opposite modulation of cotransmitter release in guinea-pig vas deferens: increase of noradrenaline and decrease of ATP release by activation of prejunctional ?-adrenoceptors

1996 • 32 citations

P2UPurinergic Activation Leads to the Cell Cycle Progression from the G1to the S and M Phases but Not from the G0to G1Phase in Vascular Smooth Muscle Cells in Primary Culture

1996 • 32 citations

The 2-chlorodeoxyadenosine-induced cell death signalling pathway in human thymocytes is different from that induced by 2-chloroadenosine

1995 • 32 citations

Existence of P2-purinoceptors on human and porcine granulosa cells.

1994 • 32 citations

Exogenous ATP and other nucleoside phosphates modulate epidermal growth factor receptors of A-431 epidermoid carcinoma cells.

1989 • 30 citations

Two distinct receptors for ATP can be distinguished in Swiss 3T6 mouse fibroblasts by their desensitization

1989 • 30 citations

Activation of Cell Growth Inhibitor by Ectoprotein Kinase-mediated Phosphorylation in Transformed Mouse Fibroblasts

1995 • 30 citations

Extracellular ATP-induced production of hydrogen peroxide in porcine thyroid cells

1990 • 30 citations

Activation of Nucleotide Receptors Inhibits High‐threshold Calcium Currents in NG108‐15 Neuronal Hybrid Cells

1996 • 29 citations

ATP as a Co‐Transmitter with Noradrenaline in Sympathetic Nerves—Function and Fate

2007 • 29 citations

Evidence for negative control of growth by adenosine in the mammalian embryo: Induction of Hmx/+ mutant limb outgrowth by adenosine deaminase

1987 • 28 citations

Novel form of drug-dependence—on adenosine in guinea pig ileum

1983 • 28 citations

Growth inhibition of breast cancer cells induced by exogenous ATP

1993 • 27 citations

Activation of early events of the mitogenic response by a P2Y purinoceptor with covalently bound 3'-O-(4-benzoyl)-benzoyladenosine 5'-triphosphate.

1990 • 26 citations

P2 purinergic receptors and cellular calcium metabolism in A 431 human epidermoid carcinoma cells

1992 • 26 citations

Anticancer activities of adenine nucleotides in tumor bearing hosts

1993 • 26 citations

Adrenergic and purinergic neurotransmission in arterial resistance vessels of the cat intestinal circulation

1989 • 26 citations

Purine and pyrimidine nucleotides activate distinct signalling pathways in PC12 cells

1995 • 25 citations

Adenine nucleotide and protein kinase C regulation of renal tubular epithelial cell wound healing

1995 • 25 citations

Control of passive permeability of chinese hamster ovary cells by external and intracellular ATP

1981 • 24 citations

2-CHLORO-N<sup>6</sup>-CYCLOPENTYLADENOSINE (CCPA), AN ADENOSINE A<sub>1</sub> RECEPTOR AGONIST, SUPPRESSES ETHANOL WITHDRAWAL SYNDROME IN RATS

1994 • 23 citations

Rapid nasal pit formation in mouse embryos stimulated by ATP‐containing medium

1981 • 23 citations

The Cloning and Expression of G Protein-Coupled P2Y Nucleotide Receptors

1998 • 23 citations

Separate P2T and P2U purinergic receptors with similar second messenger signaling pathways in UMR-106 osteoblasts.

1994 • 23 citations

Reperfusion with ATP-MgCl2 following prolonged ischemia improves myocardial performance

1987 • 22 citations

Induction of Enhanced Responsiveness of Human Articular Chondrocytes to Extracellular ATP by Tumour Necrosis Factor-α

1993 • 22 citations

ATP activates cationic and anionic conductances in Schwann cells cultured from dorsal root ganglia of the mouse

1995 • 21 citations

Selective enhancement of intratumoral blood flow in malignant gliomas using intra-arterial adenosine triphosphate

1990 • 21 citations

Purinergic mechanisms in inflammation

1996 • 20 citations

Luteolysis Is Linked to Luteinizing Hormone-Induced Depletion of Adenosine Triphosphatein Vivo*

1988 • 20 citations

ATP stimulated catecholamine secretion: Response in perfused adrenal glands and a subpopulation of cultured chromaffin cells

1995 • 19 citations

Acute paw oedema formation induced by ATP: Re-evaluation of the mechanisms involved

1996 • 18 citations

Effect of ATP synthesis promoters on postischemic myocardial recovery

1990 • 18 citations

Temporary inhibition of the initiation of motility of demembranated hamster sperm by high concentrations of ATP

1986 • 18 citations

Characterization of the effects of adenosine, adenosine 5′-triphosphate and related purines on acid secretion in isolated rabbit gastric glands

1990 • 18 citations

Effects of l-NMMA and l-NNA on the Selective ATP-Induced Enhancement of Intratumoral Blood Flow

1992 • 17 citations

P2 Purinoceptors: Localization, Function and Transduction mechanisms (Ciba Foundation Symposium 198)

1997 • 17 citations

P2 purinergic receptors potentiate parathyroid hormone receptor-mediated increases in intracellular calcium and inositol trisphosphate in UMR-106 rat osteoblasts.

1995 • 17 citations

Influence of adenosinergic drugs on ethanol withdrawal syndrome in rats.

1996 • 17 citations

Modulation of Membrane Permeability, Cell Proliferation and Cytotoxicity of Antitumor Agents by External ATP in Mouse Tumor Cells

1992 • 17 citations

Selective enhancement of intratumoural blood flow in malignant gliomas: Experimental study in rats by intracarotid administration of adenosine or adenosine triphosphate

1989 • 16 citations

Effect of purinergic substances on rectal temperature in mice: involvement of P1-purinoceptors.

1983 • 16 citations

Extracellular adenosine triphosphate. A shock to hemopoietic cells.

1995 • 16 citations

Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys

1985 • 16 citations

Regulation of thymocyte proliferation: effects of L-alanine, adenosine and cyclic AMP in vitro.

1981 • 15 citations

Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor.

1993 • 15 citations

Inhibition of natural killing by adenosine ribonucleotides

1983 • 15 citations

P2 purinoceptor-mediated stimulation of adenylyl cyclase in PC12 cells

1996 • 15 citations

Prevention of ischemic brain injury by adenosine receptor activation

1993 • 15 citations

Enhanced lipid peroxidation by extracellular ATP in PC12 cells

1996 • 14 citations

P2-purinergic stimulation of iodide efflux in FRTL-5 rat thyroid cells involves parallel activation of PLC and PLA2

1994 • 14 citations

Extracellular ATP and adenosine modulate tumor necrosis factor-induced lysis of L929 cells in the presence of actinomycin D.

1991 • 14 citations

Modulation of macrophage function by P2Y-purinergic receptors

1996 • 14 citations

Responses to cAMP Depend on Stage of Neuronal Differentiation of NGF-Treated Adrenal Chromaffin Cells

1994 • 14 citations

Effects of theophylline on the selective increases in intratumoral blood flow induced by intracarotid infusion of adenosine and adenosine triphosphate in C6 glioma-transplanted rat brains

1992 • 14 citations

ATP‐resistant variants of transformed mouse fibroblasts

1989 • 14 citations

Adenosine triphosphate-magnesium chloride in radiation injury.

1992 • 13 citations

Myocardial protection: The adenosine story

1996 • 13 citations

ATP-evoked membrane current in guinea pig adrenal chromaffin cells

1995 • 13 citations

OVERVIEW (PURINERGIC RECEPTORS)

1990 • 13 citations

ATP Release and its Prejunctional Modulation

2007 • 12 citations

Effects of ATP-Magnesium Chloride on the Cardiopulmonary Manifestations of Group B Streptococcal Sepsis in the Piglet1

1996 • 12 citations

Neurophysiological Mechanisms of Cancer Pain

1984 • 11 citations

Adenosine triphosphate release by osmotic shock and hemoglobin A1C in diabetic subjects' erythrocytes

1994 • 11 citations

Modification of survival of gamma irradiated mice by adenosine nucleotides.

1976 • 11 citations

Mucosal adenosine deaminase activity and gastric ulcer healing

1993 • 10 citations

Synergistic Effect of Extracellular Adenosine 5′-Triphosphate and Tumor Necrosis Factor on DNA Degradation

1993 • 9 citations

Immunohistochemical and electrophysiological characterization of submucous neurons from the guinea-pig small intestine in organ culture

1997 • 9 citations

Adenosine inhibition of the regeneration in vitro of adult frog sciatic sensory axons

1992 • 8 citations

Adenosine may regulate the vascular supply and thus the growth and spread of neoplastic tissues: A proposal

1981 • 7 citations

Adenosine potentiates the delaying effect of dbcAMP on meiosis resumption in denuded mouse oocytes

1986 • 7 citations

ASTROCYTE MODIFICATIONS IN NEUROLOGICAL MUTATIONS OF THE MOUSE

1986 • 7 citations

Mechanisms and Therapeutic Actions of Uridine Triphosphate in the Lung

1995 • 5 citations

TRANSMEMBRANE ION FLUX MODIFIERS VERAPAMIL AND OUABAIN MODULATE CYTOTOXIC EFFECTS OF EXTRACELLULAR ATP ON HUMAN TUMOR-CELLS IN-VITRO

1993 • 5 citations

Receptor nomenclature: how, who and when?

1987 • 5 citations

The effect of ATP-MgCl2 and dipyridamole pretreatment in renal preservation

1982 • 4 citations

Nociception from blood vessels is independent of the sympathetic nervous system under physiological conditions in humans

1997 • 4 citations

Regulatory mechanism of calcium efflux from cultured bovine adrenal chromaffin cells induced by extracellular ATP

1995 • 4 citations

Effect of Adenosine Triphosphate on the Postischemic Left Ventricular Function of the Immature Myocardium

1992 • 2 citations

Relationship between platelet density and platelet aggregation, ATP release, and cytosolic-free calcium mobilization in rabbits.

1995 • 1 citations

Detection of a Purine Analogue‐sensitive Kinase in Frog Sciatic Nerves—Possible Involvement in Nerve Regeneration

1993 • 1 citations

Deleted Work

1955 • 0 citations