Purinergic mechanisms in inflammation

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

1992 • 800 citations

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 • 658 citations

Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils.

1991 • 600 citations

Cytokines as communication signals between leukocytes and endothelial cells

1989 • 528 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1985 • 460 citations

Role of Neutrophils in Myocardial Ischemia and Reperfusion

1995 • 431 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively.

1990 • 377 citations

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.

1992 • 361 citations

Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial

1994 • 355 citations

Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.

1996 • 345 citations

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1985 • 345 citations

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

1991 • 336 citations

Platelet Function in Acute Myocardial Infarction Treated With Direct Angioplasty

1996 • 302 citations

Endotoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo

1989 • 298 citations

Differential regulatory effects of adenosine on cytokine release by activated human monocytes.

1994 • 287 citations

The effect of folic acid supplementation on the toxicity of low‐dose methotrexate in patients with rheumatoid arthritis

1990 • 251 citations

Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease

1994 • 247 citations

Tumor necrosis factor in the pathophysiology of infection and sepsis

1990 • 233 citations

Der Nucleotid-Abbau im Herzmuskel bei Sauerstoffmangel und seine m�gliche Bedeutung f�r die Coronardurchblutung

1963 • 215 citations

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.

1989 • 203 citations

The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.

1996 • 199 citations

Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury.

1993 • 198 citations

Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge.

1993 • 192 citations

Adenosine enhances IL-10 secretion by human monocytes.

1996 • 175 citations

The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine

1995 • 138 citations

Protective effect of an adenosine kinase inhibitor in septic shock.

1994 • 138 citations

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory.

1990 • 126 citations

Granulocyte activation after coronary angioplasty in humans.

1990 • 113 citations

Inhibition by adenosine of reactive oxygen metabolite production by human polymorphonuclear leucocytes

1985 • 111 citations

Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins.

1995 • 108 citations

Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs

1992 • 106 citations

Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function.

1993 • 81 citations

Anti-inflammatory effects of an adenosine kinase inhibitor. Decreased neutrophil accumulation and vascular leakage.

1995 • 75 citations

Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes.

1995 • 71 citations

The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.

1990 • 69 citations

Practical Clinical Pharmacology and Drug Interactions of Low-Dose Methotrexate Therapy in Rheumatoid Arthritis

1995 • 60 citations

Reduction of postischemic leukocyte-endothelium interaction by adenosine via A2 receptor

1992 • 48 citations

Nitric Oxide Mitigates Leukocyte Adhesion and Vascular Leak After Myocardial Ischemia

1996 • 48 citations

Selective adenosine release from human B but not T lymphoid cell line.

1990 • 45 citations

Endothelial nucleotide catabolism and adenosine production

1994 • 45 citations

Inhibition of LPS-induced TNFα production in human monocytes by adenosine (A2) receptor selective agonists

1995 • 44 citations

Stimulation of endothelial adenosine A1 receptors enhances adhesion of neutrophils in the intact guinea pig coronary system

1994 • 44 citations

Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia

1995 • 37 citations

Regulation of Platelet Adhesion to the Vessel Wall

1994 • 35 citations

Postischemic dysfunction of the heart induced by small numbers of neutrophils via formation of hypochlorous acid

1993 • 32 citations

Current Views on Structure and Function of Endothelial Adhesion Molecules

1994 • 29 citations

Glycoprotein Ib and von Willebrand Factor in the Process of Thrombus Formation

1994 • 25 citations

Tissue perfusion and organ function : ischemia--reperfusion injury

1996 • 24 citations

Adenosine: a sensitive marker of myocardial ischaemia in man

1994 • 23 citations

Modulation of Vasopressin Actions on Human Platelets by Plasma Adenosine and Theophylline

1993 • 23 citations

Thrombin Induces Platelet Adhesion to Endothelial Cells

1992 • 23 citations

Alteration of purine metabolism by AICA-riboside in human B lymphoblasts

1990 • 22 citations

Adenosine receptors and nucleoside transport sites in cardiac cells

1991 • 22 citations

Adenosine Contributes to Neutrophil-mediated Loss of Myocardial Function in Post-ischemic Guinea-pig Hearts

1993 • 21 citations

The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function

1991 • 20 citations

Protective Effect of 2-Chloroadenosine on Lung Ischemia Reperfusion Injury

1993 • 14 citations

The Role of Cytokine Networks Mediating Inflammation and Ischemia-Reperfusion Injury

1993 • 3 citations