Effects of exogenous ATP and related analogues on the proliferation rate of dissociated primary cultures of rat astrocytes

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES

1970 • 5,141 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Cardiovascular purinoceptors

1990 • 666 citations

Neuronal regulation of astroglial morphology and proliferation in vitro.

1985 • 605 citations

Extracellular Adenosine, Inosine, Hypoxanthine, and Xanthine in Relation to Tissue Nucleotides and Purines in Rat Striatum During Transient Ischemia

1987 • 424 citations

Adenosine and the concept of ‘retaliatory metabolites’

1984 • 422 citations

Adenosine receptor subtypes

1993 • 418 citations

Purine Receptors in Mammalian Tissues: Pharmacology and Functional Significance

1987 • 302 citations

Receptors and Recognition

1976 • 288 citations

Characterization of responses of isolated rat hepatocytes to ATP and ADP.

1985 • 269 citations

Increases in Cerebral Interstitial Fluid Adenosine Concentration during Hypoxia, Local Potassium Infusion, and Ischemia

1986 • 258 citations

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

1989 • 254 citations

Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system

1982 • 206 citations

Is reactive gliosis a property of a distinct subpopulation of astrocytes?

1986 • 206 citations

Changes in brain adenosine during bicuculline-induced seizures in rats. Effects of hypoxia and altered systemic blood pressure.

1980 • 196 citations

ATP‐Evoked Ca²⁺ Mobilisation and Prostanoid Release from Astrocytes: P₂‐Purinergic Receptors Linked to Phosphoinositide Hydrolysis

1989 • 156 citations

Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum

1994 • 143 citations

Hypoxanthine, xanthine and uridine in body fluids, indicators of ATP depletion

1988 • 139 citations

Mitogens for glial cells: a comparison of the response of cultured astrocytes, oligodendrocytes and schwann cells

1981 • 137 citations

Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells

1977 • 136 citations

Stimulation of the P_2Y Purinergic Receptor on Type 1 Astroglia Results in Inositol Phosphate Formation and Calcium Mobilization

1992 • 135 citations

The structure-activity relationships of ectonucleotidases and of excitatory P2-purinoceptors: evidence that dephosphorylation of ATP analogues reduces pharmacological potency

1987 • 134 citations

Treatment of human tumor cells with ADP or ATP yields arrest of growth in the S phase of the cell cycle

1983 • 133 citations

Short- and long-term consequences of intracranial injections of the excitotoxin, quinolinic acid, as evidenced by GFA immunohistochemistry of astrocytes

1986 • 122 citations

Adenosine and its nucleotides stimulate proliferation of chick astrocytes and human astrocytoma cells

1992 • 114 citations

Ra Adenosine receptors in human platelets

1984 • 102 citations

Cell Kinetic Studies of Different Cell Types In the Developing and Adult Brain of the Rat and the Mouse: A Review

1981 • 97 citations

Factors influencing astrocyte growth and development in defined media

1984 • 94 citations

Culture of purified rat astrocytes in serum-free medium supplemented with mitogen

1983 • 93 citations

Brain astrocytes express region‐specific surface glycoproteins in culture

1988 • 89 citations

Adenosine Formation and Release by Embryonic Chick Neurons and Glia in Cell Culture

1989 • 88 citations

ATP‐Evoked Arachidonic Acid Mobilization in Astrocytes Is via a P_2Y‐Purinergic Receptor

1990 • 87 citations

ATP Release, Adenosine Formation, and Modulation of Dynorphin and Glutamic Acid Release by Adenosine Analogues in Rat Hippocampal Mossy Fiber Synaptosomes

1989 • 84 citations

Excitatory Amino Acids Stimulate Inositol Phospholipid Hydrolysis and Reduce Proliferation in Cultured Astrocytes

1990 • 84 citations

Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells

1990 • 75 citations

Purification of Glycogen Phosphorylase from Bovine Brain and Immunocytochemical Examination of Rat Glial Primary Cultures Using Monoclonal Antibodies Raised Against This Enzyme

1990 • 75 citations

Effects of adenine nucleotides on the proliferation of aortic endothelial cells.

1992 • 73 citations

Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine.

1988 • 72 citations

Adenosine receptor activation in quiescent Swiss 3T3 cells

1982 • 71 citations

Distribution and Roles of Purinoceptor Subtypes

1991 • 71 citations

Receptors for adenosine and adenine nucleotides

1991 • 69 citations

Electroshock Seizures in Mice: Effect on Brain Adenosine and Its Metabolites

1981 • 64 citations

Extracellular ATP increases cytosolic free calcium in thymocytes and initiates the blastogenesis of the phorbol 12-myristate 13-acetate-treated medullary population

1987 • 63 citations

Purinergic stimulation of astroblast proliferation: Guanosine and its nucleotides stimulate cell division in chick astroblasts

1991 • 58 citations

Chapter 12: Signaling by extracellular ATP: physiological and pathological considerations in neuronal-astrocytic interactions

1992 • 58 citations

Adenosine and adenine nucleotides are mitogenic for mouse thymocytes

1978 • 58 citations

Growth factors for fetal and adult human astrocytes in culture

1988 • 58 citations

ATP-evoked calcium signal stimulates protein phosphorylation/dephosphorylation in astrocytes

1991 • 54 citations

Multiple signal transduction pathways lead to extracellular ATP‐stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation

1991 • 53 citations

Metabolism of Extracellular Adenine Nucleotides by Cultured Rat Brain Astrocytes

1991 • 47 citations

Cultures of glial cells release purines under field electrical stimulation: The possible ionic mechanisms

1988 • 44 citations

Stimulation of astrocyte proliferation by purine and pyrimidine nucleotides and nucleosides

1993 • 39 citations

Multiple signal transduction pathways lead to extracellular ATP‐stimulated mitogenesis in mammalian cells: I. Involvement of protein kinase C–dependent and –independent pathways

1991 • 34 citations

Adenosine‐dependent regulation of cyclic AMP accumulation in primary cultures of rat astrocytes and neurons

1991 • 32 citations

Cell proliferation after ischemic infarction in gerbil brain

1985 • 28 citations

Brain extracts that promote the proliferation of neuroblasts from check embryo in culture

1981 • 26 citations

Glial DNA synthesis and cell proliferation in the lesioned frontal cortex of the rat

1982 • 17 citations

Hormonal Regulation of the Proliferation and Differentiation of Astrocytes and Oligodendrocytes in Primary Culture

1985 • 16 citations

Purines stimulate chick neuroblasts proliferation in culture

1983 • 11 citations

Extracellular ATP Is a Mitogen for 3T3, 3T6, A431, DDT₁‐MF2, BALB/MK, NIE‐115, and HFF Cells^a

1990 • 11 citations

A comparison of the properties of 5'-nucleotidase purified from the cytosolic and synaptic plasma membrane fractions of rat forebrain

1991 • 10 citations

A1-mediated adenosine control and ATP P2y site involvement in protein kinase C activity and purine release from cultured astrocytes

1992 • 1 citations