Modulation of macrophage function by P2Y-purinergic receptors

Adhesion receptors of the immune system

1990 • 6,585 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Secretory products of macrophages.

1987 • 2,670 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The Cytolytic P _2Z Receptor for Extracellular ATP Identified as a P _2X Receptor (P2X ₇ )

1996 • 1,703 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

A P2X purinoceptor expressed by a subset of sensory neurons

1995 • 1,014 citations

Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

1995 • 988 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

Monocytes and Macrophages

1988 • 711 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Inflammatory mediators of pain

1995 • 607 citations

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

1993 • 587 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Cloning and functional expression of a brain G‐protein‐coupled ATP receptor

1993 • 545 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen.

1988 • 457 citations

Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.

1982 • 444 citations

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

1994 • 410 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death

1995 • 378 citations

Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen.

1988 • 374 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.

1996 • 345 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.

1995 • 303 citations

Differential regulatory effects of adenosine on cytokine release by activated human monocytes.

1994 • 287 citations

The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

1988 • 279 citations

Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein.

1992 • 260 citations

Molecular Cloning and Functional Analysis of a Novel P2 Nucleotide Receptor

1995 • 254 citations

G protein-coupled receptors for ATP and other nucleotides: a new receptor family

1994 • 252 citations

The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role.

1995 • 251 citations

Cloning and Functional Expression of a Human Uridine Nucleotide Receptor

1995 • 250 citations

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages.

1992 • 248 citations

Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization.

1994 • 235 citations

Monocyte adherence to human vascular endothelium

1993 • 205 citations

Extracellular ATP and cell signalling

1992 • 201 citations

Extracellular ATP in T-lymphocyte activation: possible role in effector functions.

1990 • 196 citations

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene

1995 • 193 citations

Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge.

1993 • 192 citations

Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.

1988 • 189 citations

The activation of protein kinase C by biologically active lipid moieties of lipopolysaccharide.

1984 • 180 citations

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

1994 • 177 citations

Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14.

1993 • 177 citations

Regulation of Inducible Nitric Oxide Synthase Expression by Macrophage Purinoreceptors and Calcium

1996 • 175 citations

Cloning of Rat and Mouse P2Y Purinoceptors

1995 • 158 citations

A novel pathway for the activation of phospholipase D by P2z purinergic receptors in BAC1.2F5 macrophages.

1992 • 154 citations

Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.

1987 • 150 citations

Pertussis Toxin Inhibition of B Cell and Macrophage Responses to Bacterial Lipopolysaccharide

1986 • 140 citations

Cloning and Chromosomal Localization of the Human P2Y1 Purinoceptor

1996 • 139 citations

Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells

1996 • 134 citations

Binding of fibrinogen to human monocytes.

1986 • 130 citations

Identification of 6H1 as a P2YPurinoceptor: P2Y5

1996 • 127 citations

Spreading of human neutrophils is immediately preceded by a large increase in cytoplasmic free calcium.

1986 • 121 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages.

1987 • 117 citations

Cloning and Characterization of a Bovine P2Y Receptor ∮

1995 • 114 citations

Cloning and Tissue Distribution of the Human P2Y1Receptor

1996 • 112 citations

Inhibition of human monocyte TNF production by adenosine receptor agonists

1993 • 109 citations

Aggregin: a platelet ADP receptor that mediates activation

1990 • 109 citations

Cloning and expression of the alveolar type II cell P2u-purinergic receptor.

1995 • 108 citations

Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts

1995 • 102 citations

A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates.

1996 • 100 citations

Activation by bacterial lipopolysaccharide causes changes in the cytosolic free calcium concentration in single peritoneal macrophages.

1991 • 94 citations

Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor.

1996 • 92 citations

Serotonin transport in isolated platelet granules. Coupling to the electrochemical proton gradient.

1981 • 86 citations

Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: Evidence for A2 receptors on rat kupffer cells

1994 • 82 citations

Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function.

1993 • 81 citations

Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes.

1995 • 71 citations

Cell-mediated cytotoxicity: ATP as an effector and the role of target cells

1991 • 62 citations

Protection of mice from endotoxic death by 2-methylthio-ATP.

1994 • 56 citations

Extracellular ATP Potentiates Nitric Oxide Synthase Expression Induced by Lipopolysaccharide in RAW-264.7 Murine Macrophages

1994 • 53 citations

LPS induces selective translocation of protein kinase C-beta in LPS-responsive mouse macrophages, but not in LPS-nonresponsive mouse macrophages.

1994 • 49 citations

Expression of the pore-forming P2Z purinoreceptor in Xenopus oocytes injected with poly(A)+ RNA from murine macrophages.

1993 • 48 citations

Macrophage tumoricidal mechanisms

1993 • 46 citations

Accumulation of lysophosphatidylinositol in RAW 264.7 macrophage tumor cells stimulated by lipid A precursors.

1987 • 45 citations

Inhibition of LPS-induced TNFα production in human monocytes by adenosine (A2) receptor selective agonists

1995 • 44 citations

Novel Therapeutic Strategies in the Treatment of Sepsis

1996 • 38 citations

Effects of Extracellular ATP on Mononuclear Phagocytes

1990 • 37 citations

Nitric oxide and anti-cancer therapy

1995 • 34 citations

Extracellular ATP stimulates poly(inositol phospholipid) hydrolysis and eicosanoid synthesis in mouse peritoneal macrophages in culture

1989 • 30 citations

ATP receptors

1994 • 28 citations

Monocyte-endothelial interactions: insights and questions.

1993 • 28 citations

ADP and ATP activate distinct signaling pathways in human promonocytic U-937 cells differentiated with 1,25-dihydroxy-vitamin D3.

1995 • 23 citations

Lipopolysaccharide-mediated signal transduction through phospholipase D activation in monocytic cell lines

1994 • 22 citations

Extracellular ATP itself elicits superoxide generation in guinea pig peritoneal macrophages

1991 • 21 citations

Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes

1991 • 20 citations

Single pulses of cytoplasmic calcium associated with phagocytosis of individual zymosan particles by macrophages

1991 • 8 citations

Mechanisms of Neutrophil and Macrophage Motility

1991 • 3 citations