Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

1993 • 587 citations

Cloning and functional expression of a brain G‐protein‐coupled ATP receptor

1993 • 545 citations

Ecto-ATPases: Identities and Functions

1995 • 503 citations

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

1994 • 410 citations

Further subclassification of ATP receptors based on agonist studies

1991 • 374 citations

Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.

1996 • 348 citations

PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses

1992 • 299 citations

Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

1997 • 286 citations

Cell membrane receptors for drugs and hormones : a multidisciplinary approach

1978 • 282 citations

P2x receptors bring new structure to ligand-gated ion channels

1995 • 277 citations

P2X Receptors: An Emerging Channel Family

1996 • 265 citations

Molecular Cloning and Functional Analysis of a Novel P2 Nucleotide Receptor

1995 • 254 citations

Cloning and Functional Expression of a Human Uridine Nucleotide Receptor

1995 • 250 citations

Second messenger cascade specificity and pharmacological selectivity of the human P_2Y1‐purinoceptor

1996 • 248 citations

Identification of competitive antagonists of the P2Y1 receptor.

1996 • 245 citations

Pharmacological selectivity of the cloned human P_2U‐purinoceptor: potent activation by diadenosine tetraphosphate

1995 • 233 citations

Pharmacological receptors on blood platelets.

1991 • 217 citations

P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

1987 • 213 citations

Kinetics of Activation of Phospholipase C by P2Y Purinergic Receptor Agonists and Guanine Nucleotides

1989 • 206 citations

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene

1995 • 193 citations

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

1994 • 177 citations

Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides

1989 • 172 citations

Cloning of Rat and Mouse P2Y Purinoceptors

1995 • 158 citations

Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.

1991 • 158 citations

Presence of diadenosine polyphosphates— Ap4A and Ap5A— In rat brain synaptic terminals. Ca2+ dependent release evoked by 4-aminopyridine and veratridine

1992 • 147 citations

Differential effects of P₂‐purinoceptor antagonists on phospholipase C‐ and adenylyl cyclase‐coupled P_2Y‐purinoceptors

1994 • 142 citations

PPADS selectively antagonizes P_2X‐purinoceptor‐mediated responses in the rabbit urinary bladder

1993 • 137 citations

Molecular Cloning of a Novel P2 Purinoceptor from Human Erythroleukemia Cells

1996 • 134 citations

Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.

1982 • 133 citations

Identification of 6H1 as a P2YPurinoceptor: P2Y5

1996 • 127 citations

Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.

1993 • 116 citations

Identification of an Ecto-nucleoside Diphosphokinase and Its Contribution to Interconversion of P2 Receptor Agonists

1997 • 114 citations

Cloning and Characterization of a Bovine P2Y Receptor ∮

1995 • 114 citations

UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y ₂ receptor

1997 • 113 citations

Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate

1993 • 113 citations

ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase

1979 • 107 citations

Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P₂ purinoceptors: Heterogeneity within P_2x and P_2y subtypes

1994 • 98 citations

Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C.

1994 • 92 citations

Blood Platelet Receptors for ADP and for Adenosine

1981 • 74 citations

Purification of pancreas type-I ATP diphosphohydrolase and identification by affinity labelling with the 5′-p-fluorosulphonylbenzoyladenosine ATP analogue

1995 • 72 citations

P2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens

1994 • 71 citations

Uptake and Flow-induced Release of Uridine Nucleotides from Isolated Vascular Endothelial Cells

1995 • 68 citations

Enzymatic synthesis of UTP_γS, a potent hydrolysis resistant agonist of P_2U‐purinoceptors

1996 • 67 citations

Membrane-delimited cell signaling complexes: Direct ion channel regulation by G Proteins

1993 • 65 citations

P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes.

1992 • 61 citations

Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase

1992 • 60 citations

Fidelity in functional coupling of the rat P2Y₁ receptor to phospholipase C

1997 • 57 citations

Adenosine and adenine nucleotides: Physiology and pharmacology

1989 • 55 citations

Diadenosine polyphosphate (Ap_xA) as new neurotransmitters

1993 • 53 citations

Adenosine and adenine nucleotides: Physiology and pharmacology

1989 • 52 citations

Inhibition of Zona Pellucida Gene Expression by Antisense Oligonucleotides Injected Into Mouse Oocytes

1995 • 50 citations

Identification of potent P_2Y‐purinoceptor agonists that are derivatives of adenosine 5′‐monophosphate

1996 • 50 citations

ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells

1989 • 50 citations

COMPETITIVE INHIBITION BY ADENOSINE 5′‐TRIPHOSPHATE OF THE ACTIONS ON HUMAN PLATELETS OF 2‐CHLOROADENOSINE 5′‐DIPHOSPHATE, 2‐AZIDOADENOSINE 5′‐DIPHOSPHATE AND 2‐METHYLTHIOADENOSINE 5′‐DIPHOSPHATE

1982 • 50 citations

Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells.

1986 • 48 citations

Pharmacological profile of the novel P₂T‐purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo

1995 • 48 citations

Identification of a G protein coupled receptor induced in activated T cells.

1993 • 45 citations

Effects of d- and l- enantiomers of adenosine, AMP and ADP and their 2-chloro- and 2-azido- analogues on human platelets

1979 • 40 citations

A Comparison of Ectonucleotidase Activities on Vascular Endothelial and Smooth Muscle Cells^a

1990 • 38 citations

Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation.

1983 • 36 citations

Potent agonist action of 2‐thioether derivatives of adenine nucleotides at adenylyl cyclase‐linked P_2y‐purinoceptors

1995 • 36 citations

ATP-diphosphohydrolases, apyrases, and nucleotide phosphohydrolases

1996 • 34 citations

Irreversible activation of phospholipase C-coupled P2Y-purinergic receptors by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate.

1989 • 30 citations

Pre-steady state study of beta-adrenergic and purinergic receptor interaction in C6 cell membranes: undelayed balance between positive and negative coupling to adenylyl cyclase.

1992 • 21 citations