Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis

1994 • 750 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

Production of transforming growth factor beta 1 during repair of arterial injury.

1991 • 539 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.

1993 • 387 citations

Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.

1992 • 383 citations

Proliferation in primary and restenotic coronary atherectomy tissue. Implications for antiproliferative therapy.

1993 • 361 citations

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

1991 • 324 citations

Antibodies against transforming growth factor-beta 1 suppress intimal hyperplasia in a rat model.

1994 • 303 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex.

1989 • 225 citations

Growth factor expression in aorta of normotensive and hypertensive rats.

1989 • 195 citations

Transforming growth factor‐β1 is a heparin‐binding protein: Identification of putative heparin‐binding regions and isolation of heparins with varying affinity for TGF‐β1

1992 • 188 citations

Effects of transforming growth factor-beta 1 on human arterial smooth muscle cells in vitro.

1991 • 171 citations

Intron-exon structure of the human transforming growth factor-β precursor gene

1987 • 159 citations

Regulation of extracellular matrix RNA levels in cultured smooth muscle cells

1989 • 151 citations

Vascular Smooth Muscle Cells Express Distinct Transforming Growth Factor-β Receptor Phenotypes as a Function of Cell Density in Culture

1989 • 137 citations

Growth characteristics and cytoskeletal organization of cultured smooth muscle cells from human primary stenosing and restenosing lesions.

1990 • 128 citations

Proliferation and extracellular matrix synthesis of smooth muscle cells cultured from human coronary atherosclerotic and restenotic lesions

1994 • 125 citations

Vascular smooth muscle cell growth kinetics in vivo in aged rats.

1982 • 118 citations

Protection of transforming growth factor β activity by heparin and fucoidan

1994 • 100 citations

Transforming growth factor‐β1 stimulates macrophage urokinase expression and release of matrix‐bound basic fibroblast growth factor

1993 • 97 citations

Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury.

1986 • 96 citations

Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells.

1993 • 70 citations

Different Signals Mediate Transforming Growth Factor-β1-Induced Growth Inhibition and Extracellular Matrix Production in Prostatic Carcinoma Cells

1993 • 70 citations

Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.

1991 • 69 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

Growth characteristics and cytoskeletal organization of cultured smooth muscle cells from human primary stenosing and restenosing lesions.

1990 • 65 citations

Transforming growth factor β1 is a powerful modulator of platelet‐derived growth factor action in vascular smooth muscle cells

1992 • 64 citations

Role of Transforming Growth Factor-β in Repair and Fibrosis

1991 • 62 citations

Modulation of vascular cell behavior by transforming growth factors β

1992 • 61 citations

Transforming growth factor β1‐mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest

1993 • 61 citations

Adult human aortic smooth muscle cells in culture produce active TGF-beta

1993 • 60 citations

Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries.

1995 • 58 citations

Abnormal growth regulation of vascular smooth muscle cells by heparin in patients with restenosis

1993 • 56 citations

Characterization of transforming growth factor-beta-resistant subclones isolated from a transforming growth factor-beta-sensitive human colon carcinoma cell line.

1988 • 37 citations

Heparin decreases the rate of proliferation of rat vascular smooth muscle cells by releasing transforming growth factor -like activity from serum

1993 • 34 citations

POTENTIAL ROLE OF HUMAN CYTOMEGALOVIRUS AND p53 INTERACTION IN CORONARY RESTENOSIS

1995 • 20 citations

Stimulation of fibronectin production by TGF‐β₁ is independent of effects on cell proliferation: The example of bovine adrenocortical cells

1990 • 19 citations

Heparin decreases the rate of proliferation of rat vascular smooth muscle cells by releasing transforming growth factor [5-like activity from serum

1993 • 2 citations