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MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

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1992 • 781 citations

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1992 • 500 citations

SMADs: mediators and regulators of TGF-β signaling

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A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities

1993 • 388 citations

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

1993 • 356 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

Transforming growth factor β1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

1998 • 311 citations

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1996 • 299 citations

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1997 • 289 citations

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1992 • 242 citations

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1995 • 234 citations

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Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway

1997 • 168 citations

Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.

1993 • 165 citations

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.

1997 • 145 citations

Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice.

1993 • 138 citations

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β

1996 • 125 citations

Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.

1999 • 124 citations

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1996 • 107 citations

Expression of transforming growth factor-? (TGF-?) isoforms in osteosarcomas

1997 • 93 citations

Clinical relevance of urokinase plasminogen activator, its receptor, and its inhibitor in patients with renal cell carcinoma

1996 • 88 citations

Transforming growth factor beta1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro.

1996 • 83 citations

Up-regulation of Transforming Growth Factor (TGF)-β Receptors by TGF-β1 in COLO-357 Cells

1998 • 80 citations

Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line

1998 • 75 citations

In situ expression of transforming growth factor ?? is associated with melanoma progression and correlates with Ki67, HLA-DR and ?? 3 integrin expression

1997 • 71 citations

Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer

1998 • 69 citations

Time-varying prognostic impact of tumour biological factors urokinase (uPA), PAI-1 and steroid hormone receptor status in primary breast cancer

1997 • 61 citations

Concomitant over-expression of activin/inhibin β subunits and their receptors in human pancreatic cancer

1998 • 61 citations

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Prognostic significance of PAI-1 and uPA in cytosolic extracts obtained from node-positive breast cancer patients

1997 • 51 citations

Novel mutations in the polyadenine tract of the transforming growth factor β type II receptor gene are found in a subpopulation of human pancreatic adenocarcinomas

1998 • 46 citations

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1997 • 43 citations

Transforming growth factor–beta1 inhibits generation of angiostatin by human pancreatic cancer cells

1998 • 31 citations

The plasminogen activator/plasmin system is up-regulated after acute necrotizing pancreatitis in human beings

1998 • 18 citations

Dominant-Negative SMAD-3 Interferes with Transcriptional Activation by Multiple Agonists

1997 • 16 citations

Transforming Growth Factor-β Isoforms Expressions in Pulmonary Adenocarcinomas as Prognostic Markers

1997 • 15 citations

TYPE-1 PLASMINOGEN ACTIVATOR INHIBITOR IN HUMAN RENAL CELL CARCINOMA

1996 • 14 citations