Ceramide in apoptosis—does it really matter?

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome

1996 • 536 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

1995 • 469 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

1997 • 306 citations

Sphingomyelin Synthase, a Potential Regulator of Intracellular Levels of Ceramide and Diacylglycerol during SV40 Transformation

1998 • 290 citations

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

1997 • 286 citations

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

1996 • 274 citations

Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?

1998 • 267 citations

TNF-Induced Activation of NF-κB

1995 • 240 citations

Sphingomyelin breakdown and cell fate

1996 • 212 citations

Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)

1995 • 209 citations

A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.

1996 • 206 citations

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1994 • 198 citations

Early events in TNF signaling: a story of associations and dissociations

1997 • 194 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

1998 • 171 citations

Identification of a Domain in the Angiotensin II Type 1 Receptor Determining Gq Coupling by the Use of Receptor Chimeras

1995 • 169 citations

KSR stimulates Raf-1 activity in a kinase-independent manner

1997 • 166 citations

Expression of Neutral Sphingomyelinase Identifies a Distinct Pool of Sphingomyelin Involved in Apoptosis

1997 • 159 citations

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells

1998 • 150 citations

A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway

1996 • 150 citations

Isolation of cDNA clones encoding human acid sphingomyelinase: occurrence of alternatively processed transcripts.

1989 • 149 citations

Fas-induced apoptosis of T cells occurs independently of ceramide generation

1997 • 123 citations

CD95 (Fas/APO-1) Induces Ceramide Formation and Apoptosis in the Absence of a Functional Acid Sphingomyelinase

1998 • 102 citations

Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue

1998 • 77 citations

Apoptotic Signal of Fas Is Not Mediated by Ceramide

1998 • 66 citations

Tumor Necrosis Factor α Activates NF-κB in Acid Sphingomyelinase-deficient Mouse Embryonic Fibroblasts

1997 • 64 citations

Niemann-Pick disease

1989 • 61 citations

Evidence that neutral spingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane

1984 • 55 citations

Membrane-Destabilizing Properties of C₂-Ceramide May Be Responsible for Its Ability To Inhibit Platelet Aggregation

1998 • 53 citations

Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity

1997 • 46 citations

Molecular properties and kinetic studies on sphingomyelinase of Bacillus cereus

1982 • 44 citations

Dag Second Messengers: Molecular Switches and Growth Control

1997 • 24 citations

Molecular architecture and dynamics of the plasma membrane lipid bilayer: The red blood cell as a model

1991 • 19 citations