Dag Second Messengers: Molecular Switches and Growth Control

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Identification and Characterization of Zinc Binding Sites in Protein Kinase C

1991 • 193 citations

Regulation of protein kinase C activity by lipids

1988 • 155 citations

The regulatory domain of protein kinase C coordinates four atoms of zinc.

1992 • 129 citations

Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.

1986 • 127 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.

1990 • 103 citations

The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.

1994 • 84 citations

Protein Kinase C, a Zinc Metalloprotein: Quantitation of Zinc by Atomic Absorption Spectrometry

1993 • 4 citations