Identification of a Domain in the Angiotensin II Type 1 Receptor Determining Gq Coupling by the Use of Receptor Chimeras

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

1991 • 1,247 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

1991 • 808 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase

1992 • 252 citations

Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells.

1993 • 251 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.

1990 • 230 citations

Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure.

1992 • 201 citations

Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes.

1990 • 192 citations

Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.

1990 • 171 citations

Conformational change of mastoparan from wasp venom on binding with phospholipid membrane

1983 • 168 citations

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

1993 • 162 citations

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

1992 • 157 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein

1994 • 147 citations

Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.

1994 • 136 citations

Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers.

1990 • 132 citations

Domains for G-protein coupling in angiotensin II receptor type I: Studies by site-directed mutagenesis

1992 • 129 citations

Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells.

1994 • 124 citations

Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors

1993 • 114 citations

Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover

1989 • 107 citations

Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha.

1994 • 104 citations

Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.

1994 • 97 citations

The rat angiotensin II AT1A receptor couples with three different signal transduction pathways

1992 • 97 citations

Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.

1994 • 89 citations

Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor.

1993 • 67 citations

Angiotensin II stimulates protein tyrosine phosphatase activity through a G-protein independent mechanism.

1994 • 56 citations

Protein-Tyrosine-Phosphatase Inhibition by Angiotensin-II in Rat Pheochromocytoma Cells Through Type-2 Receptor, at(2)

1994 • 47 citations

Angiotensin II stimulates phosphorylation of nuclear lamins via a protein kinase C-dependent mechanism in cultured vascular smooth muscle cells.

1990 • 44 citations

The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation.

1994 • 39 citations

Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling.

1994 • 39 citations

Inositol 1, 4, 5-trisphosphate-induced calcium mobilization is localized in Xenopus oocytes

1989 • 28 citations

Attenuation of GTPase activity of recombinant G(o) alpha by peptides representing sequence permutations of mastoparan.

1992 • 28 citations

[11] Chloride current assay for phospholipase C in Xenopus oocytes

1994 • 13 citations

Coupling an receptor peptide to G-protein: A new photolabeling agent

1994 • 9 citations

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