Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.

1995 • 1,619 citations

A Direct Estimate of the Human αβ T Cell Receptor Diversity

1999 • 893 citations

T CELL MEMORY

1998 • 863 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes

1993 • 474 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire

1993 • 437 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Size Estimate of the αβ TCR Repertoire of Naive Mouse Splenocytes

2000 • 297 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

5. Terminal Deoxynucleotidyl Transferase

1974 • 199 citations

T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region Genes

1985 • 197 citations

Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires

1998 • 192 citations

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

1992 • 154 citations

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire

1995 • 143 citations

The E-T (Elephant-Tadpole) paradox necessitates the concept of a unit of b-cell function: The protecton

1987 • 119 citations

The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells.

1991 • 109 citations

The mechanism of V(D)J recombination: A balance of diversity, specificity, and stability

1992 • 106 citations

Mice Lacking Terminal Deoxynucleotidyl Transferase: Adult Mice with a Fetal Antigen Receptor Repertoire

1995 • 105 citations

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

1992 • 92 citations

Terminal deoxynucleotidyl transferase

1981 • 80 citations

T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4+ T Cell Response in Vivo

2000 • 77 citations

Efficient immune responses in mice lacking N‐region diversity

1995 • 74 citations

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase

1994 • 54 citations

Identification of a Late Stage of Small Noncycling pTα− Pre-T Cells as Immediate Precursors of T Cell Receptor α/β+ Thymocytes

1998 • 40 citations

Terminal Deoxynucleotidyl Transferase Deficiency Reduces the Incidence of Autoimmune Nephritis in (New Zealand Black × New Zealand White)F1 Mice

1998 • 37 citations

Comparison of the Jβ gene usage among different T cell receptor Vβ families in spleens of C57BL/6 mice

1994 • 21 citations

Methylation of the promoter region may be involved in tissue-specific expression of the mouse terminal deoxynucleotidyl transferase gene 1 1Edited by M. Yaniv

1999 • 11 citations

Deleted Work

1955 • 0 citations