Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis

1989 • 1,357 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Regulation of Antigen-Specific CD8 ⁺ T Cell Homeostasis by Perforin and Interferon-γ

2000 • 452 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

2001 • 349 citations

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

2001 • 314 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens

2001 • 264 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection

1998 • 229 citations

Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants.

1992 • 219 citations

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen.

2001 • 219 citations

The thymus and negative selection

2002 • 216 citations

Differentiating between Memory and Effector Cd8 T Cells by Altered Expression of Cell Surface O-Glycans

2000 • 207 citations

Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

2000 • 174 citations

Single-Cell PCR Analysis of TCR Repertoires Selected by Antigen In Vivo: A High Magnitude CD8 Response Is Comprised of Very Few Clones

1996 • 174 citations

T-cell selection

1998 • 168 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.

1997 • 146 citations

Stability and Diversity of T Cell Receptor Repertoire Usage during Lymphocytic Choriomeningitis Virus Infection of Mice

1998 • 141 citations

Thymic Selection by a Single MHC/Peptide Ligand Produces a Semidiverse Repertoire of CD4+ T Cells

1997 • 134 citations

Cd2 Sets Quantitative Thresholds in T Cell Activation

1999 • 129 citations

Modification of Cysteine Residues In Vitro and In Vivo Affects the Immunogenicity and Antigenicity of Major Histocompatibility Complex Class I–restricted Viral Determinants

1999 • 117 citations

Immunodominance in Virus-Induced CD8⁺T-Cell Responses Is Dramatically Modified by DNA Immunization and Is Regulated by Gamma Interferon

2002 • 109 citations

Peptide‐induced T cell receptor down‐regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

1997 • 89 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

Manipulation of Avidity to Improve Effectiveness of Adoptively Transferred CD8+ T Cells for Melanoma Immunotherapy in Human MHC Class I-Transgenic Mice

2001 • 86 citations

Increased TCR Avidity after T Cell Activation

2001 • 67 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

Functional management of an antiviral cytotoxic T-cell response

1997 • 64 citations

Characterization of CD8+ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas

2000 • 63 citations

Tracing and characterization of the low-avidity self-specific T cell repertoire

2000 • 58 citations

Using Transgenic Mouse Models to Dissect the Pathogenesis of Virus‐Induced Autoimmune Disorders of the Islets of Langerhans and the Central Nervous System

1996 • 48 citations

The Thymus and Negative Selection

2000 • 46 citations

Low-Affinity Cytotoxic T-Lymphocytes Require IFN-γ to Clear an Acute Viral Infection

1997 • 45 citations

Virus persistence and immune memory

1994 • 7 citations