The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

1989 • 661 citations

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

1987 • 631 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids

1981 • 489 citations

Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1981 • 449 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

A human hepatitis B viral enhancer element.

1985 • 286 citations

GAL4 derivatives function alone and synergistically with mammalian activators in vitro

1988 • 274 citations

cis and trans activation of globin gene transcription in transient assays.

1983 • 257 citations

When the products of oncogenes and anti-oncogenes meet

1989 • 213 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus

1984 • 155 citations

Hepatitis B virus X gene can transactivate heterologous viral sequences.

1989 • 137 citations

Regulation of HIV and HTLV gene expression.

1988 • 128 citations

Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer

1989 • 125 citations

Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.

1987 • 119 citations

Nucleotide sequence of a cloned woodchuck hepatitis virus genome: evolutional relationship between hepadnaviruses

1985 • 117 citations

Cellular factors that interact with the hepatitis B virus enhancer.

1989 • 108 citations

Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression.

1988 • 107 citations

Identification of a promoter element located upstream from the hepatitis B virus X gene.

1987 • 103 citations

Purification and characterization of multiple nuclear factors that bind to the TAX-inducible enhancer within the human T-cell leukemia virus type 1 long terminal repeat.

1989 • 81 citations

Identification of a region within the human immunodeficiency virus type 1 long terminal repeat that is essential for transactivation by the hepatitis B virus gene X

1989 • 68 citations

Identification of a Promoter Element Located Upstream from the Hepatitis B Virus X Gene

1987 • 44 citations

Cellular Factors That Interact with the Hepatitis B Virus Enhancer

1989 • 43 citations

Purification and Characterization of Multiple Nuclear Factors That Bind to the TAX-Inducible Enhancer within the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1989 • 38 citations