The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

The packing of α-helices: simple coiled-coils

1953 • 1,549 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

DNA RECOGNITION BY PROTEINS WITH THE HELIX-TURN-HELIX MOTIF

1990 • 580 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer

1992 • 422 citations

Methods and programs for direct-space exploitation of geometric redundancies

1976 • 383 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

Saturation Mutagenesis of the Yeast his3 Regulatory Site: Requirements for Transcriptional Induction and for Binding by GCN4 Activator Protein

1986 • 352 citations

Defining the Sequence Specificity of DNA-Binding Proteins by Selecting Binding Sites from Random-Sequence Oligonucleotides: Analysis of Yeast GCN4 Protein

1989 • 333 citations

Sequence-Specific DNA Binding by a Short Peptide Dimer

1990 • 318 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

Fos-Jun heterodimers and jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity

1991 • 296 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous

1987 • 260 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein.

1989 • 207 citations

Equilibrium dissociation and unfolding of the arc repressor dimer

1989 • 202 citations

Altered protein conformation on DNA binding by Fos and Jun

1990 • 193 citations

Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes.

1989 • 191 citations

DNA Bending by Fos and Jun: The Flexible Hinge Model

1991 • 186 citations

Unbiased three-dimensional refinement of heavy-atom parameters by correlation of origin-removed Patterson functions

1983 • 169 citations

Transcription factor interactions: basics on zippers

1991 • 124 citations

DNA-induced increase in the .alpha.-helical content of C/EBP and GCN4

1991 • 121 citations

Molecular characterization of the GCN4-DNA complex.

1990 • 101 citations

Mutations That Define the Optimal Half-Site for Binding Yeast GCN4 Activator Protein and Identify an ATF/CREB-Like Repressor That Recognizes Similar DNA Sites

1990 • 100 citations

Structural Motif of the GCN4 DNA Binding Domain Characterized by Affinity Cleaving

1990 • 91 citations

Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping "leucine zippers"

1989 • 90 citations

The DNA Binding Arm of λ Repressor: Critical Contacts from a Flexible Region

1991 • 88 citations

Solution structure of the basic region from the transcriptional activator GCN4

1991 • 80 citations

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

1991 • 79 citations

Identification of an amino acid–base contact in the GCN4–DNA complex by bromouracil-mediated photocrosslinking

1992 • 76 citations

Thermal unfolding studies of a leucine zipper domain and its specific DNA complex: implications for scissor's grip recognition

1990 • 73 citations

Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.

1990 • 67 citations

Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: The GCN4-DNA complex

1992 • 66 citations

Dynamic filtering by two-dimensional 1H NMR with application to phage lambda repressor.

1984 • 40 citations

Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.

1990 • 38 citations

Zinc-finger structures

1992 • 33 citations

Zinc-finger structures

1992 • 27 citations