Anionic phospholipids, interfacial binding and the regulation of cell functions

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Annexin V-Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure

1998 • 1,850 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Experimentally determined hydrophobicity scale for proteins at membrane interfaces

1996 • 1,581 citations

Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins

1994 • 1,113 citations

MOLECULAR BASIS FOR MEMBRANE PHOSPHOLIPID DIVERSITY: Why Are There So Many Lipids?

1997 • 956 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

The Preference of Tryptophan for Membrane Interfaces

1998 • 891 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement

1993 • 831 citations

Properties and Regulation of Cytosolic Phospholipase A2

1997 • 814 citations

The growing phospholipase A2 superfamily of signal transduction enzymes

1997 • 811 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

1998 • 733 citations

The role of lipids in pulmonary surfactant

1998 • 705 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

REGULATION AND INHIBITION OF PHOSPHOLIPASE A₂

1999 • 574 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Regulatory Functions of Phospholipase A2

1997 • 551 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

Hydrophobic interactions of peptides with membrane interfaces

1998 • 536 citations

Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

1987 • 534 citations

Cytosolic phospholipase A2

1995 • 530 citations

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

1996 • 526 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking

1998 • 515 citations

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum

1995 • 469 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

Activation of cultured vascular endothelial cells by antiphospholipid antibodies.

1995 • 425 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia

1998 • 395 citations

Antimicrobial peptides of vertebrates

1998 • 377 citations

Crystal Structure of Human Cytosolic Phospholipase A2 Reveals a Novel Topology and Catalytic Mechanism

1999 • 358 citations

Lipid polymorphism and protein–lipid interactions

1998 • 351 citations

Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways

1999 • 350 citations

Annexins and membrane dynamics

1997 • 345 citations

Ca2+-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V

1995 • 299 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1998 • 289 citations

Lipid–protein interactions in blood coagulation

1998 • 288 citations

The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes

1995 • 286 citations

Structure of the binding site for inositol phosphates in a PH domain.

1995 • 281 citations

Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules

1998 • 279 citations

Binding of small basic peptides to membranes containing acidic lipids: theoretical models and experimental results

1996 • 273 citations

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

1998 • 268 citations

Cardiolipin activation of dnaA protein, the initiation protein of replication in Escherichia coli.

1988 • 266 citations

The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting

1989 • 261 citations

Bactericidal properties of murine intestinal phospholipase A2.

1995 • 260 citations

Reversibility of the Binding of Cytochrome c to Liposomes

1995 • 258 citations

Structure, dynamics and composition of the lipid-protein interface. Perspectives from spin-labelling

1998 • 255 citations

Secretory Phospholipase A ₂ Is the Principal Bactericide for Staphylococci and Other Gram-Positive Bacteria in Human Tears

1998 • 253 citations

Crystal and molecular structure of human annexin V after refinement

1992 • 249 citations

Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane?

1997 • 236 citations

Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver

1989 • 228 citations

Maintenance and consequences of membrane phospholipid asymmetry

1994 • 218 citations

CTP:phosphocholine cytidylyltransferase

1997 • 215 citations

Annexin Structure and Membrane Interactions: A Molecular Perspective

1994 • 212 citations

Isolation and Characterization of the Gene (CLS1 ) Encoding Cardiolipin Synthase in Saccharomyces cerevisiae

1998 • 212 citations

Anionic phospholipids are determinants of membrane protein topology

1997 • 210 citations

The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14-kD phospholipase A2.

1996 • 208 citations

INTERFACIAL ENZYMOLOGY OF GLYCEROLIPID HYDROLASES: Lessons from Secreted Phospholipases A₂

1995 • 204 citations

Mechanism of Phospholipid Binding by the C₂A-Domain of Synaptotagmin I

1998 • 191 citations

Binding of Basic Peptides to Membranes Produces Lateral Domains Enriched in the Acidic Lipids Phosphatidylserine and Phosphatidylinositol 4,5-Bisphosphate: An Electrostatic Model and Experimental Results

1998 • 189 citations

Regulation of phosphatidylcholine biosynthesis

1990 • 187 citations

Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly

1990 • 186 citations

Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non‐fermentable carbon sources

1997 • 182 citations

Group IV Cytosolic Phospholipase A2 Binds with High Affinity and Specificity to Phosphatidylinositol 4,5-Bisphosphate Resulting in Dramatic Increases in Activity

1998 • 176 citations

Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2

1999 • 176 citations

The electrostatics of lipid surfaces

1999 • 171 citations

Lipid polymorphism and biomembrane function

1997 • 171 citations

Electrostatics and the Membrane Association of Src: Theory and Experiment

1998 • 162 citations

Phosphoinositide-specific phospholipase C-.delta.1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

1992 • 162 citations

Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2

1993 • 157 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites

1996 • 150 citations

Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles

1997 • 148 citations

Lipid dynamics and peripheral interactions of proteins with membrane surfaces

1994 • 148 citations

A Ternary Metal Binding Site in the C2 Domain of Phosphoinositide-Specific Phospholipase C-δ1^,

1997 • 146 citations

Characterization of Phosphatidylserine-dependent β2-Glycoprotein I Macrophage Interactions

1998 • 146 citations

In vivo evidence for the involvement of anionic phospholipids in initiation of DNA replication in Escherichia coli.

1995 • 141 citations

A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A2

1999 • 137 citations

Primary structure of human placental anticoagulant protein

1987 • 132 citations

Phosphoinositide Binding Domains

1999 • 130 citations

Calcium-dependent Membrane Penetration Is a Hallmark of the C2 Domain of Cytosolic Phospholipase A2 Whereas the C2A Domain of Synaptotagmin Binds Membranes Electrostatically

1998 • 128 citations

Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane

1995 • 122 citations

Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodies.

1998 • 116 citations

Phospholipid-binding protein domains

1998 • 116 citations

Phosphatidylinositol 4,5-Bisphosphate Binding to the Pleckstrin Homology Domain of Phospholipase C-δ1 Enhances Enzyme Activity

1996 • 115 citations

Lipocortin inhibition of extracellular and intracellular phospholipases A₂ is substrate concentration dependent

1987 • 115 citations

Interfacial binding of secreted phospholipases A2: more than electrostatics and a major role for tryptophan

1999 • 113 citations

Mutagenesis of the C2 Domain of Protein Kinase C-α

1998 • 112 citations

Anionic phospholipids stimulate an arachidonoyl-hydrolyzing phospholipase A2 from macrophages and reduce the calcium requirement for activity

1990 • 107 citations

Influence of Cluster Formation of Acidic Phospholipids on Decrease in the Affinity for ATP of DnaA Protein

1996 • 106 citations

Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A 2 1 1Edited by J. Karn

1998 • 106 citations

C2 domain conformational changes in phospholipase C-δ1

1996 • 104 citations

Phospholipase D

1998 • 104 citations

Importance of phosphatidylethanolamine for association of protein kinase C and other cytoplasmic proteins with membranes

1992 • 100 citations

Docking Phospholipase A ₂ on Membranes Using Electrostatic Potential-Modulated Spin Relaxation Magnetic Resonance

1998 • 100 citations

Cell-wall determinants of the bactericidal action of group IIA phospholipase A2 against Gram-positive bacteria

1999 • 100 citations

Mapping the Interfacial Binding Surface of Human Secretory Group IIa Phospholipase A₂

1997 • 99 citations

On the molecular-level mechanisms of peripheral protein-membrane interactions induced by lipids forming inverted non-lamellar phases

1996 • 99 citations

Anionic Phospholipids Modulate Peptide Insertion into Membranes

1997 • 98 citations

Human β2-Glycoprotein I Binds to Endothelial Cells Through a Cluster of Lysine Residues That Are Critical for Anionic Phospholipid Binding and Offers Epitopes for Anti-β2-Glycoprotein I Antibodies

1998 • 96 citations

The electrostatic basis for the interfacial binding of secretory phospholipases A2

1994 • 93 citations

A Conserved Motif in the Tail Domain of Vinculin Mediates Association with and Insertion into Acidic Phospholipid Bilayers

1998 • 91 citations

High specificity of human secretory class II phospholipase A2 for phosphatidic acid

1997 • 90 citations

Solid-state NMR approaches for studying the interaction of peptides and proteins with membranes

1998 • 89 citations

Action of Human Group IIa Secreted Phospholipase A2on Cell Membranes

1998 • 88 citations

Tryptophan-Containing Mutant of Human (Group IIa) Secreted Phospholipase A₂ Has a Dramatically Increased Ability To Hydrolyze Phosphatidylcholine Vesicles and Cell Membranes

1998 • 82 citations

Purification and characterization of a novel protein from bovine aorta that inhibits coagulation

1988 • 80 citations

Interfacial membrane docking of cytosolic phospholipase A ₂ C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance

1999 • 80 citations

Location of the Membrane-Docking Face on the Ca²⁺-Activated C2 Domain of Cytosolic Phospholipase A₂

1998 • 79 citations

Differential Membrane-Binding and Activation Mechanisms of Protein Kinase C-α and -ε

1998 • 79 citations

Relationship between annexin V tryptophan exposure, calcium, and phospholipid binding

1993 • 78 citations

Phosphatidylglycerol Is a Physiologic Activator of Nuclear Protein Kinase C

1998 • 75 citations

Enzymatic and Cellular Characterization of a Catalytic Fragment of CTP:Phosphocholine Cytidylyltransferase α

1999 • 70 citations

A continuous fluorescence displacement assay for the measurement of phospholipase A2 and other lipases that release long-chain fatty acids

1990 • 70 citations

Ca2+ concentration during binding determines the manner in which annexin V binds to membranes

1995 • 69 citations

Calcium-Dependent and -Independent Interfacial Binding and Catalysis of Cytosolic Group IV Phospholipase A₂

1998 • 68 citations

Random versus Selective Membrane Phospholipid Oxidation in Apoptosis: Role of Phosphatidylserine

1998 • 67 citations

Membrane-mediated Release of Nucleotide from an Initiator of Chromosomal Replication, Escherichia coli DnaA, Occurs with Insertion of a Distinct Region of the Protein into the Lipid Bilayer

1998 • 64 citations

Phospholipid Determinants for Annexin V Binding Sites and the Role of Tryptophan 187

1994 • 63 citations

Anti-endothelial cell antibody binding makes negatively charged phospholipids accessible to antiphospholipid antibodies

1998 • 60 citations

Activation of Phospholipase D by Phosphatidic Acid

1998 • 56 citations

The Role of Anionic Lipids in Protein Insertion and Translocation in Bacterial Membranes

1998 • 52 citations

Anionic phospholipids and protein translocation

1994 • 52 citations

Interfacial Recognition by Bee Venom Phospholipase A₂: Insights into Nonelectrostatic Molecular Determinants by Charge Reversal Mutagenesis

1998 • 51 citations

Modulation of the activities of enzymes of membrane lipid metabolism by non-bilayer-forming lipids

1996 • 51 citations

Evidence for the Extended Phospholipid Conformation in Membrane Fusion and Hemifusion

1999 • 49 citations

A rise in nuclear calcium translocates annexins IV and V to the nuclear envelope

1996 • 46 citations

Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2

1994 • 46 citations

ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles

1998 • 46 citations

Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?

1995 • 42 citations

Binding of annexin V to bilayers with various phospholipid compositions using glass beads in a flow cytometer

1998 • 41 citations

Effects of sphingosine on peripheral membrane interactions: Comparison of adriamycin, cytochrome c, and phospholipase A2

1993 • 41 citations

Lipid Structure and Not Membrane Structure Is the Major Determinant in the Regulation of Protein Kinase C by Phosphatidylserine

1998 • 40 citations

Inhibition of secreted phospholipases A2 by annexin V. Competition for anionic phospholipid interfaces allows an assessment of the relative interfacial affinities of secreted phospholipases A2

1998 • 38 citations

Interaction of Annexin VI with membranes: Highly restricted dissipation of clustered phospholipids in membranes containing phosphatidylethanolamine

1992 • 38 citations

Mechanism of the Apparent Cooperativity in the Interaction of Protein Kinase C with Phosphatidylserine

1998 • 37 citations

Site-directed Mutational Analysis for the Membrane Binding of DnaA Protein

1998 • 36 citations

Annexin V Binding to the Outer Leaflet of Small Unilamellar Vesicles Leads to Altered Inner Leaflet Properties: 31P- and 1H-NMR Studies

1994 • 35 citations

Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase

1997 • 35 citations

Pleckstrin Homology Domain as an Inositol Compound Binding Module

1998 • 35 citations

How cytidylyltransferase uses an amphipathic helix to sense membrane phospholipid composition

1998 • 30 citations

Subcellular localization of annexin V in human foreskin fibroblasts: nuclear localization depends on growth state

1996 • 30 citations

Dissociation of Cytochrome c from Liposomes by Histone H1. Comparison with Basic Peptides^,

1996 • 27 citations

[56] Glycosylphosphatidylinositol-specific phospholipase D

1991 • 27 citations

Electrostatic Interactions during Acidic Phospholipid Reactivation of DnaA Protein, the Escherichia coli Initiator of Chromosomal Replication

1999 • 27 citations

Direct Enthalpy Measurements of the Calcium-Dependent Interaction of Annexin V and VI with Phospholipid Vesicles

1994 • 26 citations

The Chirality of Phosphatidylserine and the Activation of Protein Kinase C

1998 • 23 citations

Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4, 5-Bisphosphate

1998 • 23 citations

Phospholipase D and phosphatidic acid enhance the hydrolysis of phospholipids in vesicles and in cell membranes by human secreted phospholipase A2

1998 • 19 citations

Involvement of Arg-328, Arg-334 and Arg-342 of DnaA protein in the functional interaction with acidic phospholipids

1999 • 15 citations

Studies of membrane physical properties and their role in biological function

1997 • 15 citations

Comparison of the properties of human group II phospholipase A2 with other secretory phospholipases

1994 • 14 citations

Involvement of Arg-328, Arg-334 and Arg-342 of DnaA protein in the functional interaction with acidic phospholipids

1999 • 10 citations

58 The effect of phosphatidylinositols on cytosolic phospholipase A2 activity using a continuous fluorescent displacement assay

1997 • 5 citations

Protein conformational distortions induced by membrane interfacial interactions

1997 • 3 citations

Additions and Corrections

1995 • 3 citations