The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Intracellular phospholipases A

1980 • 989 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Dynamic and static aspects of solubilization of neutral arenes in ionic micellar solutions

1979 • 649 citations

INTERFACIAL ENZYME KINETICS OF LIPOLYSIS

1976 • 573 citations

Phospholipid Bilayers: Physical Principles and Models

1987 • 505 citations

Action of Phospholipase A at Interfaces

1973 • 498 citations

Phospholipid Bilayers: Physical Principles and Models

1987 • 495 citations

Structure and function of phospholiphase A2

1981 • 478 citations

Phospholipase A2 and its zymogen from porcine pancreas. VI. Histidine at the active site of phospholipase A2

1974 • 465 citations

A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

1987 • 428 citations

A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom.

1985 • 396 citations

An Introduction to Biological Membranes

2016 • 369 citations

Enzyme reactions in a membrane model 1: A new technique to study enzyme reactions in monolayers

1973 • 353 citations

Phospholipase A2: Function and pharmacological regulation

1987 • 347 citations

The substrate specificity of phospholipase A

1963 • 330 citations

The Water and Nonelectrolyte Permeability Induced in Thin Lipid Membranes by the Polyene Antibiotics Nystatin and Amphotericin B

1970 • 317 citations

Studies on phospholipase A and its zymogen from porcine pancreas

1971 • 298 citations

Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism

1980 • 292 citations

INHIBITION OF PHOSPHOLIPASE

1983 • 284 citations

Introduction to Biological Membranes

1980 • 277 citations

Phospholipase A2 and its zymogen from porcine pancreas. VII. Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2

1974 • 271 citations

Active site and catalytic mechanism of phospholipase A2

1981 • 231 citations

[14] Enzyme kinetics of lipolysis

1980 • 229 citations

Action of pancreatic phospholipase A2 on phosphatidylcholine bilayers in different physical states

1975 • 228 citations

[15] Phospholipase A2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas

1974 • 226 citations

Physical chemical studies of short-chain lecithin homologues. I.

1974 • 214 citations

Interaction of phospholipase A₂ with micellar interfaces. Role of the N-terminal region

1975 • 206 citations

Kinetic dependence of phospholipase A2 activity on the detergent Triton X-100

1973 • 205 citations

Hydrolysis of phosphatidylcholine liposomes by pancreatic phospholipase A2 at the transition temperature

1974 • 196 citations

Studies on phospholipase a and its zymogen from porcine pancreas IV. The influence of chemical modification of the lecithin structure on substrate properties

1972 • 192 citations

Long-Range Order in Biomembranes

1977 • 175 citations

Exchange and interactions between lipid layers at the surface of a liposome solution

1979 • 165 citations

Hydrolysis of dipalmitoylphosphatidylcholine large unilamellar vesicles by porcine pancreatic phospholipase A2.

1986 • 163 citations

Phospholipase A2 activity towards phosphatidylcholine in mixed micelles: Surface dilution kinetics and the effect of thermotropic phase transitions

1973 • 161 citations

9 Phospholipases

1983 • 159 citations

Phospholipase A2 and its zymogen from porcine pancreas. V. Interaction of phospholipase A2 and its zymogen with divalent metal ions

1974 • 159 citations

Mechanism of interfacial activation of phospholipase A2

1974 • 156 citations

Substrate specificity of pancreatic lipase

1968 • 149 citations

Further studies of mode of action of lipolytic enzymes.

1977 • 145 citations

Lipid-protein interactions in monolayers

1982 • 145 citations

Interaction of phospholipase A2 and phospholipid bilayers

1982 • 142 citations

Kinetic analysis of the dual phospholipid model for phospholipase A2 action.

1984 • 135 citations

Origin of the latency phase during the action of phospholipase A2 on unmodified phosphatidylcholine vesicles

1982 • 134 citations

Regulation of Eicosanoid Production: Role of Phospholipases and Inhibitors

1987 • 129 citations

Kinetic analysis of the hydrolysis of lecithin monolayers by phospholipase A

1971 • 123 citations

Orientation constraints in diffusion-limited macromolecular association. The role of surface diffusion as a rate-enhancing mechanism

1985 • 120 citations

Kinetics of interfacial catalysis by phospholipase A2 in intravesicle scooting mode, and heterofusion of anionic and zwitterionic vesicles

1986 • 119 citations

Action of phospholipases A2 on phosphatidylcholine bilayers. Effects of the phase transition, bilayer curvature and structural defects

1978 • 114 citations

Regulation of phospholipase A2 activity by the lipid-water interface: a monolayer approach

1979 • 111 citations

Conformational properties of phospholipases A₂

1983 • 111 citations

Hydrolysis of dipalmitoylphosphatidylcholine small unilamellar vesicles by porcine pancreatic phospholipase A2.

1986 • 108 citations

The spontaneous incorporation of proteins into preformed bilayers

1987 • 102 citations

Comparative studies of lipase and phospholipase A2 acting on substrate monolayers.

1976 • 100 citations

Activation, aggregation, and product inhibition of cobra venom phospholipase A2 and comparison with other phospholipases.

1985 • 98 citations

Bradykinin highlights the role of phospholipid metabolism in the control of nerve excitability

1987 • 94 citations

Structure and thermodynamic properties of the complexes between phospholipase A2 and lipid micelles

1979 • 93 citations

Receptor-activation of phospholipase A2 in cellular signalling

1987 • 87 citations

Intrinsic perturbing ability of alkanols in lipid bilayers

1978 • 87 citations

Binding of phospholipase A2 to zwitterionic bilayers is promoted by lateral segregation of anionic amphiphiles

1989 • 85 citations

The chemical basis for interfacial activation of monomeric phospholipases A2. Autocatalytic derivatization of the enzyme by acyl transfer from substrate.

1988 • 84 citations

The activation of porcine pancreatic phospholipase A2 by dipalmitoylphosphatidylcholine large unilamellar vesicles. Analysis of the state of aggregation of the activated enzyme.

1987 • 83 citations

Phospholipid activation of cobra venom phospholipase A2. 1. Lipid-lipid or lipid-enzyme interaction

1979 • 82 citations

Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2

1984 • 81 citations

Action of phospholipase A2 on unmodified phosphatidylcholine bilayers: Organizational defects are preferred sites of action

1980 • 80 citations

Synthesis and evaluation of phospholipid analogs as inhibitors of cobra venom phospholipase A2

1987 • 80 citations

Holes in a stearic acid monolayer observed by dark-field electron microscopy

1987 • 79 citations

Physicochemical studies on the interaction of pancreatic phospholipase A2 with a micellar substrate analog

1981 • 76 citations

An Analysis of Unstirred Layers in Series with "Tight" and "Porous" Lipid Bilayer Membranes

1971 • 73 citations

Action of cobra venom phospholipase A2 on the gel and liquid crystalline states of dimyristoyl and dipalmitoyl phosphatidylcholine vesicles.

1979 • 69 citations

Action of phospholipase A2 on bilayers. Effect of inhibitors

1985 • 67 citations

Hydrolysis of monomeric substrates by porcine pancreatic (pro)phospholipase A₂. The use of a spectrophotometric assay

1979 • 66 citations

Phospholipid transfer between phosphatidylcholine-taurocholate mixed micelles

1988 • 66 citations

Evidence for the control of the action of phospholipases A by the physical state of the substrate

1984 • 65 citations

Relationship between the activity of pancreatic phospholipase A2 and the physical state of the phospholipid substrate.

1981 • 64 citations

Phospholipase A2 inhibition and modification by manoalogue

1988 • 62 citations

Dehydration of the lipid-protein microinterface on binding of phospholipase A2 to lipid bilayers

1987 • 61 citations

The kinetics of the phospholipase A2-catalyzed hydrolysis of Egg phosphatidylcholine in unilamellar vesicles. Product inhibition and its relief by serum albumin.

1981 • 61 citations

Ca²⁺ion binding to porcine pancreatic phospholipase A₂ and its function in enzyme-lipid interaction

1978 • 60 citations

Phospholipases. I. Effect ofn-alkanols on the rate of enzymatic hydrolysis of egg phosphatidylcholine

1973 • 56 citations

Interaction of Phospolipase A₂ form Naja melanoleuca Sanke Venom with Meoomeric Substrate Analogs

1983 • 56 citations

Analysis of the kinetics of phospholipid activation of cobra venom phospholipase A2.

1984 • 56 citations

Activation of phospholipase A2 by freshly added lysophospholipids

1983 • 55 citations

Action of phospholipase A2 on bilayers containing lysophosphatidylcholine analogs and the effect of inhibitors

1984 • 54 citations

Recent advances in the characterization of epithelial ionic channels

1987 • 53 citations

Activation of porcine pancreatic phospholipase A2 by the presence of negative charges at the lipid-water interface

1986 • 53 citations

Effect of the structure of phospholipid on the kinetics of intravesicle scooting of phospholipase A2

1986 • 52 citations

Amino acid sequence of a basic Agkistrodon halys blomhoffii phospholipase A2. Possible role of amino-terminal lysines in action on phospholipids of Escherichia coli

1986 • 50 citations

What do we know about micelles and which questions are still open?

1981 • 48 citations

Complex photophysics of the single tryptophan of porcine pancreatic phospholipase A2, its zymogen, and an enzyme/micelle complex

1985 • 46 citations

Anchoring of phospholipase A2: the effect of anions and deuterated water, and the role of N-terminus region

1986 • 46 citations

A new class of phospholipase A2 substrates: kinetics of the phospholipase A2 catalyzed hydrolysis of 3-(acyloxy)-4-nitrobenzoic acids

1988 • 45 citations

Kinetics of binding of phospholiphase A2 to lipid/ water interfaces and its relationship to interfacial activation

1988 • 44 citations

Characterization, cell-free synthesis and processing of apolipoprotein A-I of rat high-density lipoproteins

1981 • 43 citations

Action of phospholipase A2 on bilayers. Effect of fatty acid and lysophospholipid additives on the kinetic parameters

1985 • 42 citations

The affinity of phospholipase A2 for the interface of the substrate and analogs

1986 • 40 citations

Heterogeneous catalysis by phospholipase A₂: formulation of a kinetic description of surface effects

1979 • 39 citations

Aggregation of porcine pancreatic phospholipase A2 and its zymogen induced by submicellar concentration of negatively charged detergents

1983 • 38 citations

Short-chain phosphatidylethanolamines: physical properties and susceptibility of the monomers to phospholipase A2 action

1985 • 37 citations

Intrinsic differences in the perturbing ability of alkanols in bilayer: Action of phospholipase A2 on the alkanol-modified phospholipid bilayer

1980 • 37 citations

Kinetic behavior of porcine pancreatic phospholipase A2 on zwitterionic and negatively charged single-chain substrates

1985 • 37 citations

Effect of the state of phosphatidylcholine on the rate of its hydrolysis by phospholipase A2 (bee venom)

1978 • 37 citations

Physical chemical studies of short-chain lecithin homologues

1974 • 36 citations

Application of enantiomeric 2-sn-phosphatidylcholines in interfacial enzyme kinetics of lipolysis

1976 • 36 citations

Regulation of phospholipase A2 activity by different lipid-water interfaces.

1977 • 35 citations

Action of phospholipase A₂ on phospholipid vesicles

1979 • 34 citations

Kinetics of hydrolysis of dispersions of saturated phosphatidylcholines by Crotalus atrox phospholipase A₂

1978 • 33 citations

Binding of porcine pancreatic phospholipase A2 to various micellar substrate analogs. The involvement of histidine-48 and aspartic acid-49 in the binding process

1981 • 32 citations

Enzymic hydrolysis of short-chain lecithin/long-chain phospholipid unilamellar vesicles: sensitivity of phospholipases to matrix phase state

1987 • 30 citations

Hydrolysis of Mixed Monomolecular Filme of phosphatidulchoiline/Triacylglycerol by Pancereatic Phospholipase A₂

1983 • 29 citations

Phospholipases. II. Enzymatic hydrolysis of lecithin: Effects of structure, cholesterol content, and sonication

1973 • 29 citations

Calcium ion binding to pancreatic phospholipase A2 and its zymogen: a calcium-43 NMR study

1984 • 28 citations

Catalytic calcium binding site of pancreatic phospholipase A2: laser-induced europium(3+) luminescence study

1985 • 27 citations

Localization of the second calcium ion binding site in porcine and equine phospholipase A2

1983 • 26 citations

Unusual kinetic behavior of porcine pancreatic (pro)phospholipase A2 on negatively charged substrates at submicellar concentrations

1983 • 22 citations

Further studies on a phospholipase A2 isolated from human platelet plasma membranes

1981 • 21 citations

Thermodynamic model for micelle formation by phosphatidylcholines containing short-chain fatty acids. Correlations with physical-chemical data and the effects of concentration on the activity of phospholipase A2

1979 • 20 citations

The role of lysyl residues of phospholipases A2 in the formation of the catalytic complex

1985 • 20 citations

Rapid phospholipase A2 stimulation and diacylglycerol cholinephosphotransferase inhibition in baby hamster kidney cells during initiation of dengue virus infection

1981 • 20 citations

Lipid-induced aggregation of phospholipase A2: sucrose density gradient ultracentrifugation and crosslinking studies

1988 • 20 citations

The environment of tryptophan in pig pancreatic phospholipase A2 bound to bilayers

1985 • 20 citations

Solute-induced acceleration of transbilayer movement and its implications on models of blood-brain barrier

1985 • 19 citations

Phase properties of the aqueous dispersions of n-octadecylphosphocholine

1985 • 19 citations

A Sodium-independent Mechanism for L-Arginine Uptake by Rat Renal Brush Border Membrane Vesicles

1983 • 18 citations

Control of the action of phospholipases A by "vertical compression" of the substrate monolayer

1987 • 17 citations

Structural importance of the amino-terminal residue of pancreatic phospholipase A2

1984 • 16 citations

Effect of pH on the kinetic and spectral properties of Crotalus adamanteus phospholipase A₂ in H₂O and D₂O

1974 • 15 citations

Kinetic behavior of porcine pancreatic phospholipase A2 on zwitterionic and negatively charged double-chain substrates

1985 • 15 citations

Self-association and active enzyme forms of Naja naja naja and Crotalus atrox phospholipase A2 studied by analytical ultracentrifugation

1986 • 14 citations

Interaction of pancreatic phospholipases A2 and semisynthetic mutants with anionic substrates and substrate analogs

1987 • 14 citations

Heterogeneous catalysis by phospholipase A₂: mechanism of hydrolysis of gel phase phosphatidylcholine

1980 • 13 citations

Amino acid substitutions of the amino-terminal Ala1 of porcine pancreatic phospholipase A2: a monolayer study

1979 • 13 citations

Induction of a latency period in the time-course of phospholipase A2 action on dipalmitoylphosphatidylcholine liposomes in the gel phase

1988 • 11 citations

Phospholipases. III. Effects of ionic surfactants on the phospholipase-catalyzed hydrolysis of unsonicated egg lecithin liposomes

1975 • 10 citations

Cobra venom phospholipase A2 immobilized to porous glass beads

1978 • 9 citations

Evidence that the zymogen of phospholipase A2 binds to a negatively charged lipid-water interface

1984 • 6 citations

Kinetics of the Hydrolysis of Monodispersed Dihexanoyllecithin Catalyzed by a Cobra (Naja naja atra) Venom Phospholipase A21

1985 • 5 citations