Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Structural chemistry and molecular biology

1968 • 1,698 citations

Lipid Asymmetry in Membranes

1979 • 1,245 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

The Electrostatic Properties of Membranes

1989 • 1,032 citations

Electrostatic Potentials at Membrane-Solution Interfaces

1977 • 822 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

An introduction to the principles of surface chemistry

1974 • 522 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

Binding of acylated peptides and fatty acids to phospholipid vesicles: Pertinence to myristoylated proteins

1993 • 498 citations

The MARCKS family of cellular protein kinase C substrates.

1993 • 484 citations

Entropic forces between amphiphilic surfaces in liquids

1992 • 479 citations

The Marcks brothers: A family of protein kinase C substrates

1992 • 474 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

The influence of polyvalency on the binding properties of antibodies

1972 • 396 citations

Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane

1991 • 372 citations

Binding of myosin I to membrane lipids

1989 • 287 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Fluorometric Evaluation of the Affinities of Isoprenylated Peptides for Lipid Bilayers

1994 • 253 citations

MYOSIN-I

1991 • 252 citations

Binding of peptides with basic residues to membranes containing acidic phospholipids

1991 • 236 citations

Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.

1994 • 233 citations

Fine-tuning the topology of a polytopic membrane protein: Role of positively and negatively charged amino acids

1990 • 221 citations

Regulation of phospholipase C by G proteins

1992 • 205 citations

Protein Involvement in Transmembrane Lipid Asymmetry

1992 • 200 citations

Interaction of Proteins With Lipid Headgroups: Lessons from Protein Kinase C

1993 • 184 citations

Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles.

1994 • 182 citations

Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins.

1993 • 179 citations

Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals.

1989 • 169 citations

Phosphoinositide-specific phospholipase C-.delta.1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

1992 • 162 citations

Receptor tyrosine kinase substrates: src homology domains and signal transduction

1992 • 156 citations

Membrane Binding of Myristylated Peptides Corresponding to the NH2 Terminus of Src

1994 • 154 citations

Phosphorylation reverses the membrane association of peptides that correspond to the basic domains of MARCKS and neuromodulin

1994 • 152 citations

Interaction of myristoylated alanine-rich protein kinase C substrate (MARCKS) with membrane phospholipids

1993 • 145 citations

Reduction-of-dimensionality kinetics at reaction-limited cell surface receptors

1994 • 144 citations

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

1991 • 139 citations

Effect of Monolayer Surface Pressure on the Activities of Phosphoinositide-Specific Phospholipase C-.beta.1, -.gamma.1, and -.delta.1

1994 • 119 citations

High Cooperativity, Specificity, and Multiplicity in the Protein Kinase C-Lipid Interaction

1989 • 116 citations

The src protein contains multiple domains for specific attachment to membranes.

1990 • 112 citations

Binding of basic peptides to acidic lipids in membranes: effects of inserting alanine(s) between the basic residues

1992 • 99 citations

Extensive segregation of acidic phospholipids in membranes induced by protein kinase C and related proteins

1991 • 97 citations

Interaction of divalent antibody with cell surface antigens

1979 • 91 citations

Biochimica et biophysica acta

1987 • 90 citations

Molecular aspects of the bilayer stabilization induced by poly(l-lysines) of varying size in cardiolipin liposomes

1985 • 86 citations

Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserine

1993 • 86 citations

Interaction of tyrosine kinase oncoproteins with cellular membranes

1993 • 77 citations

2H and 31P NMR study of pentalysine interaction with headgroup deuterated phosphatidylcholine and phosphatidylserine

1988 • 76 citations

Electrostatics and reduction of dimensionality produce apparent cooperativity when basic peptides bind to acidic lipids in membranes

1992 • 71 citations

Interaction of peptide fragment 828-848 of the envelope glycoprotein of human immunodeficiency virus type I with lipid bilayers

1993 • 68 citations

Lipid transmembrane asymmetry and flip-flop in biological membranes and in lipid bilayers

1993 • 63 citations

Thermodynamic characterization of the association of small basic peptides with membranes containing acidic lipids

1993 • 62 citations

Association of a cellular myosin II with anionic phospholipids and the neuronal plasma membrane.

1994 • 55 citations

Selectivity of interaction of phospholipids with bovine spinal cord myelin basic protein studied by spin-label electron spin resonance

1989 • 44 citations

Lateral diffusion in membranes

1983 • 43 citations

Enhancement by protein kinase C of prostacyclin receptor-mediated activation of adenylate cyclase through a calmodulin/myristoylated alanine-rich C kinase substrate (MARCKS) system in IC2 mast cells.

1993 • 26 citations

Protein kinase C: Current concepts and future perspectives

1993 • 20 citations