Binding of small basic peptides to membranes containing acidic lipids: theoretical models and experimental results

Classical Electrostatics in Biology and Chemistry

1995 • 2,801 citations

The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions

1971 • 1,417 citations

Role of hydration and water structure in biological and colloidal interactions

1996 • 1,304 citations

The nature of the accessible and buried surfaces in proteins

1976 • 1,151 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

The Electrostatic Properties of Membranes

1989 • 1,032 citations

Calculations of electrostatic interactions in biological systems and in solutions

1984 • 992 citations

Preferred conformation and molecular packing of phosphatidylethanolamine and phosphatidylcholine

1981 • 883 citations

Energy of an Ion crossing a Low Dielectric Membrane: Solutions to Four Relevant Electrostatic Problems

1969 • 832 citations

Focusing of electric fields in the active site of Cu‐Zn superoxide dismutase: Effects of ionic strength and amino‐acid modification

1986 • 759 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structure

1992 • 688 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

Energy functions for peptides and proteins. I. Derivation of a consistent force field including the hydrogen bond from amide crystals

1974 • 662 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

The molecular structure of lecithin dihydrate

1979 • 617 citations

Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids

1994 • 532 citations

Binding of acylated peptides and fatty acids to phospholipid vesicles: Pertinence to myristoylated proteins

1993 • 498 citations

The MARCKS family of cellular protein kinase C substrates.

1993 • 484 citations

The Marcks brothers: A family of protein kinase C substrates

1992 • 474 citations

Phospholipid head groups as sensors of electric charge in membranes

1987 • 402 citations

Incorporation of surface tension into molecular dynamics simulation of an interface: a fluid phase lipid bilayer membrane

1995 • 372 citations

Neutron diffraction studies on phosphatidylcholine model membranes

1979 • 347 citations

Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers

1987 • 272 citations

Three-dimensional Structure of the Human Immunodeficiency Virus Type 1 Matrix Protein

1994 • 267 citations

Binding of peptides with basic residues to membranes containing acidic phospholipids

1991 • 236 citations

Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.

1994 • 233 citations

Osmotic properties of large unilamellar vesicles prepared by extrusion

1993 • 213 citations

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.

1990 • 195 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

Stability of "salt bridges" in membrane proteins.

1984 • 176 citations

Salt Effects on Ligand-DNA Binding

1994 • 173 citations

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

1994 • 165 citations

Phosphoinositide-specific phospholipase C-.delta.1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

1992 • 162 citations

Membrane Binding of Myristylated Peptides Corresponding to the NH2 Terminus of Src

1994 • 154 citations

Phosphorylation reverses the membrane association of peptides that correspond to the basic domains of MARCKS and neuromodulin

1994 • 152 citations

Salt Effects on Protein-DNA Interactions

1994 • 149 citations

Analysis of side-chain organization on a refined model of charybdotoxin: structural and functional implications

1992 • 148 citations

Calculations of the electrostatic potential adjacent to model phospholipid bilayers

1995 • 139 citations

The role of charge and hydrophobicity in peptide-lipid interaction: a comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers

1990 • 137 citations

The molecular organisation of bimolecular lipid membranes. The dielectric structure of the hydrophilic/hydrophobic interface

1981 • 136 citations

Hydration and Steric Pressures between Phospholipid Bilayers

1994 • 131 citations

Effect of Monolayer Surface Pressure on the Activities of Phosphoinositide-Specific Phospholipase C-.beta.1, -.gamma.1, and -.delta.1

1994 • 119 citations

Membrane insertion and lateral mobility of synthetic amphiphilic signal peptides in lipid model membranes

1991 • 103 citations

Binding of basic peptides to acidic lipids in membranes: effects of inserting alanine(s) between the basic residues

1992 • 99 citations

Electrostatic fields in antibodies and antibody/antigen complexes

1992 • 99 citations

Molecular aspects of the bilayer stabilization induced by poly(l-lysines) of varying size in cardiolipin liposomes

1985 • 86 citations

Conformational analysis of the polar head group in phosphatidylcholine bilayers: a structural change induced by cations

1991 • 85 citations

Interaction of tyrosine kinase oncoproteins with cellular membranes

1993 • 77 citations

2H and 31P NMR study of pentalysine interaction with headgroup deuterated phosphatidylcholine and phosphatidylserine

1988 • 76 citations

Electrostatics and reduction of dimensionality produce apparent cooperativity when basic peptides bind to acidic lipids in membranes

1992 • 71 citations

Poisson-Boltzmann analysis of the lambda repressor-operator interaction

1992 • 71 citations

Membrane domains containing phosphatidylserine and substrate can be important for the activation of protein kinase C

1995 • 66 citations

Thermodynamic characterization of the association of small basic peptides with membranes containing acidic lipids

1993 • 62 citations

Electrostatic potentials and electrostatic interaction energies of rat cytochrome b5 and a simulated anion-exchange adsorbent surface

1994 • 52 citations

Interaction of a substance P agonist and of substance P antagonists with lipid membranes. A thermodynamic analysis

1992 • 49 citations

N-Terminally Myristoylated Ras Proteins Require Palmitoylation or a Polybasic Domain for Plasma Membrane Localization

1994 • 48 citations

Electrostatic control of the efficiency of light-induced electron transfer across membranes

1981 • 45 citations

Structure and dynamics of the phosphatidylcholine and the phosphatidylethanolamine head group in L-M fibroblasts as studied by deuterium nuclear magnetic resonance.

1987 • 44 citations

Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?

1995 • 42 citations

Interfacial conformation of dipalmitoylglycerol and dipalmitoylphosphatidylcholine in phospholipid bilayers

1992 • 32 citations

The membrane interaction of amphiphilic model peptides affects phosphatidylserine headgroup and acyl chain order and dynamics. Application of the "phospholipid headgroup electrometer" concept to phosphatidylserine

1991 • 22 citations

A Limiting Law for the Electrostatics of the Binding of Polypeptides to Phospholipid Bilayers

1995 • 19 citations