Mutagenesis of the C2 Domain of Protein Kinase C-α

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Insoluble monolayers at liquid-gas interfaces

1966 • 2,626 citations

Techniques of lipidology (isolation, analysis and identification of lipids

1974 • 2,557 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Insoluble Monolayers at Liquid-gas Interfaces

1966 • 2,252 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Metabolism of Glycerolipids

1960 • 779 citations

Techniques of Lipidology

1973 • 777 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Relation between various phospholipase actions on human red cell membranes and the interfacial phospholipid pressure in monolayers

1975 • 548 citations

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

1996 • 526 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helices

1989 • 437 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

A comparative study of the phase transitions of phospholipid bilayers and monolayers

1979 • 393 citations

Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.

1994 • 352 citations

A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions

1982 • 331 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

Ca2+-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V

1995 • 299 citations

Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers

1987 • 272 citations

Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

1998 • 268 citations

Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

1994 • 209 citations

Tryptophans in membrane proteins: Indole ring orientations and functional implications in the gramicidin channel

1993 • 190 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

1992 • 180 citations

Phosphoinositide-specific phospholipase C-.delta.1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

1992 • 162 citations

Lipid-protein interactions in monolayers

1982 • 145 citations

Ca²⁺-Signaling Cycle of a Membrane-Docking C2 Domain

1997 • 117 citations

Protein kinase C interaction with calcium: a phospholipid-dependent process

1990 • 116 citations

C2 domain conformational changes in phospholipase C-δ1

1996 • 104 citations

Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation

1992 • 102 citations

Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding

1992 • 94 citations

A new kinetic approach for studying phospholipase C (Clostridium perfringens .alpha. toxin) activity on phospholipid monolayers

1988 • 88 citations

Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserine

1993 • 86 citations

Differential Membrane-Binding and Activation Mechanisms of Protein Kinase C-α and -ε

1998 • 79 citations

Structural Aspects of Interfacial Adsorption

1997 • 78 citations

Purification and characterization of protein kinase C .epsilon. from rabbit brain

1992 • 77 citations

Regulation of Protein Kinase C βII by Its C2 Domain

1997 • 75 citations

Chemical specificity and physical properties of the lipid bilayer in the regulation of protein kinase C by anionic phospholipids: evidence for the lack of a specific binding site for phosphatidylserine.

1996 • 43 citations

A Structure-Function Study of Bovine Pancreatic Phospholipase A2 Using Polymerized Mixed Liposomes

1995 • 41 citations

Proteins that bind calcium in a phospholipid-dependent manner

1991 • 41 citations

Roles of Surface Hydrophobic Residues in the Interfacial Catalysis of Bovine Pancreatic Phospholipase A₂

1996 • 34 citations

A Putative Phosphatidylserine Binding Motif Is Not Involved in the Lipid Regulation of Protein Kinase C

1997 • 30 citations

A Phospholipase A2Kinetic and Binding Assay Using Phospholipid-Coated Hydrophobic Beads

1997 • 29 citations

Interactions of annexin V with phospholipid monolayers

1996 • 26 citations

Effects of Specific Fatty Acid Acylation of Phospholipase A2 on Its Interfacial Binding and Catalysis

1994 • 17 citations