Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

2003 • 794 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

Cells: a laboratory manual

1998 • 635 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Cbl: many adaptations to regulate protein tyrosine kinases

2001 • 621 citations

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

2000 • 580 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

2002 • 431 citations

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

2002 • 417 citations

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

1998 • 400 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking

2001 • 386 citations

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

2002 • 378 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan.

1988 • 335 citations

ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors

1999 • 332 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

2001 • 316 citations

Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits

2003 • 306 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

2002 • 264 citations

Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency

1998 • 208 citations

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

2001 • 200 citations

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor

1999 • 194 citations

RING Finger Mutations that Abolish c-Cbl-Directed Polyubiquitination and Downregulation of the EGF Receptor Are Insufficient for Cell Transformation

2001 • 180 citations

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

1988 • 173 citations

The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system

2002 • 169 citations

Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase

1998 • 167 citations

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins

1996 • 166 citations

Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex

2001 • 160 citations

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

2002 • 155 citations

Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis

2001 • 147 citations

Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.

1994 • 144 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

2000 • 143 citations

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation

2001 • 132 citations

Negative regulation of Lck by Cbl ubiquitin ligase

2002 • 128 citations

The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation

2000 • 122 citations

Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

1997 • 119 citations

High frequency of SV40 transformation of mouse cell line 3T3

1966 • 106 citations

The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.

1996 • 97 citations

Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.

1995 • 89 citations

A Leucine-based Determinant in the Epidermal Growth Factor Receptor Juxtamembrane Domain Is Required for the Efficient Transport of Ligand-Receptor Complexes to Lysosomes

1999 • 85 citations

Growth Hormone-induced Signal Transduction Depends on an Intact Ubiquitin System

1997 • 69 citations

EGF receptor residues Leu679, Leu680 mediate selective sorting of ligand-receptor complexes in early endosomal compartments

2000 • 66 citations

Endocytosis of Epidermal Growth Factor Receptor Regulated by Grb2-mediated Recruitment of the Rab5 GTPase-activating Protein RN-tre

2002 • 57 citations

cbl-b Inhibits EGF-Receptor-Induced Apoptosis by Enhancing Ubiquitination and Degradation of Activated Receptors

1999 • 53 citations

Lipid and membrane protein transfer from human neutrophils to schistosomes is mediated by ligand binding

1993 • 23 citations