Reduced Activity of the Interferon-induced Double-stranded RNA-dependent Protein Kinase during a Heat Shock Stress

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Improved technique utilizing nonfat dry milk for analysis of proteins and nucleic acids transferred to nitrocellulose

1984 • 1,697 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

1978 • 435 citations

Heat shock proteins: the search for functions.

1986 • 395 citations

Interferon action may be mediated by activation of a nuclease by pppA2′p5′A2′p5′A

1978 • 310 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Coming in from the cold

1988 • 285 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

Constitutive expression of (2′–5′) oligo A synthetase confers resistance to picornavirus infection

1987 • 277 citations

Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins

1985 • 265 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

1983 • 203 citations

2B or not 2B: Regulation of the catalytic utilization of elF-2

1983 • 172 citations

Protein Denaturation during Heat Shock and Related Stress

1989 • 166 citations

Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.

1979 • 155 citations

c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock.

1988 • 154 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.

1987 • 112 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

Activation of hemin-regulated initiation factor-2 kinase in heat-shocked HeLa cells.

1986 • 84 citations

Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells

1985 • 81 citations

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1985 • 78 citations

Inhibition of vesicular stomatitis viral mRNA synthesis by interferons

1987 • 78 citations

Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.

1988 • 73 citations

Studies on the role of the 2'-5'-oligoadenylate synthetase-RNase L pathway in beta interferon-mediated inhibition of encephalomyocarditis virus replication

1988 • 61 citations

Interferon Action III. The Rate of Primary Transcription of Vesicular Stomatitis Virus is Inhibited by Interferon Action

1978 • 45 citations

Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication.

1985 • 44 citations

[19] Enzymology of interferon action—A short survey

1981 • 42 citations

Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections

1987 • 40 citations

Interferon pretreatment lowers the threshold for maximal heat‐shock response in mouse cells

1986 • 36 citations

Regulation of the heat‐shock response by interferon in mouse L cells

1988 • 25 citations

Inhibition of HeLa cell protein synthesis under heat shock conditions in the absence of initiation factor eIF-2α phosphorylation

1986 • 19 citations

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