Interferon-Induced and Double-Stranded RNA-Activated Enzymes: A Specific Protein Kinase and 2′,5′-Oligoadenylate Synthetases

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis

1977 • 750 citations

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

1978 • 435 citations

Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis

1976 • 435 citations

Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells

1977 • 367 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Interferon, double-stranded RNA, and protein phosphorylation.

1976 • 328 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates

1975 • 254 citations

Water in Biological Systems

1971 • 242 citations

Specific phosphorylation in vitro of a protein associated with ribosomes of interferon‐treated mouse L cells

1976 • 238 citations

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

1987 • 229 citations

Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates

1971 • 204 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK

1989 • 202 citations

Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences.

1985 • 201 citations

Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA

1977 • 198 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

Increased sensitivity of cell-free protein synthesis to double-stranded RNA after interferon treatment

1974 • 179 citations

The (2′‐5′)Oligoadenylate (pppA2′‐5′A2′‐5′A) Synthetase and Protein Kinase(s) from Interferon‐Treated Cells

1979 • 173 citations

2B or not 2B: Regulation of the catalytic utilization of elF-2

1983 • 172 citations

Anticellular and antiviral effects of pppA(2′p5′A)n

1980 • 164 citations

Synthesis of an Oligonucleotide Inhibitor of Protein Synthesis in Rabbit Reticulocyte Lysates Analogous to that Formed in Extracts from Interferon‐Treated Cells

1978 • 164 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.

1979 • 155 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Mechanism of Interferon Action: Inhibition of Viral Messenger Ribonucleic Acid Translation in L-Cell Extracts

1972 • 154 citations

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1989 • 143 citations

Synthesis and Breakdown of pppA2′p5′A2′p5′A and Transient Inhibition of Protein Synthesis in Extracts from Interferon‐Treated and Control Cells

1978 • 140 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: Dependence on double-stranded RNA

1976 • 118 citations

The double‐stranded RNA‐dependent protein kinase is also activated by heparin

1987 • 116 citations

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.

1987 • 112 citations

The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

1991 • 111 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

Activation of a nuclease by pppA2′p5′ A2′p5′ A in intact cells

1979 • 108 citations

Monitoring of Interferon Therapy by Assay of (2′-5′) Oligo-Isoadenylate Synthetase in Human Peripheral White Blood Cells

1981 • 99 citations

Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.

1985 • 98 citations

Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.

1990 • 79 citations

Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA.

1976 • 78 citations

Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts.

1985 • 78 citations

Mechanism of interferon action Kinetics of interferon action in mouse L929 cells: Translation inhibition, protein phosphorylation, and messenger RNA methylation and degradation

1977 • 78 citations

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1985 • 78 citations

3′ End structure of the human (2′–5′) oligo A synthetase gene: prediction of two distinct proteins with cell type-specific expression

1985 • 77 citations

Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.

1988 • 73 citations

Continuous Production of Interferon in Normal Mice: Effect of Anti-interferon Globulin, Sex, Age, Strain and Environment on the Levels of 2-5A Synthetase and p67K Kinase

1985 • 72 citations

Vaccinia specific kinase inhibitory factor prevents translational inhibition by double-stranded RNA in rabbit reticulocyte lysate

1989 • 63 citations

Further characterization of the protein kinase activity mediated by interferon in mouse and human cells.

1984 • 60 citations

2′5′oligo(A) polymerase activity in serum of mice infected with EMC virus or treated with interferon

1980 • 56 citations

p67K kinase in different tissues and plasma of control and interferon-treated mice

1982 • 52 citations

Measures and countermeasures in the modulation of initiation factor activities by viruses.

1990 • 51 citations

Inhibition of Protein Synthesis in Cell-Free Systems from Interferon-Treated, Infected Cells: Further Characterization and Effect of Formylmethionyl-tRNA _F

1974 • 50 citations

A type 1 phosphoprotein phosphatase active with phosphorylated Mr = 68,000 initiation factor 2 kinase

1989 • 47 citations

Full‐length sequence and expression of the 42 kDa 2–5A synthetase induced by human interferon

1986 • 45 citations

Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection

1990 • 43 citations

[19] Enzymology of interferon action—A short survey

1981 • 42 citations

Assay and the levels of 2-5A-synthetase in lymphocytes of patients with viral, bacterial and autoimmune diseases

1983 • 32 citations

Variation of (2′-5′) Oligo A Synthetase Level in Lymphocytes and Granulocytes of Patients with Viral Infections and Leukemia

1982 • 30 citations

Enhanced Level of Double-Stranded RNA-Dependent Protein Kinase in Peripheral Blood Mononuclear Cells of Patients with Viral Infections

1986 • 27 citations

Preparation and characterization of polyclonal antibodies specific for the 69 and 100 K-dalton forms of human 2–5A synthetase

1989 • 27 citations

Induction des activités 2-5A-synthétase et protéine-kinase dans le foie et la rate de souris infectées par le virus de la maladie de Newcastle ou traitées par le poly(I)poly(C)

1980 • 25 citations

Kinetics of dephosphorylation of eIF-2(alpha P) and reutilization of mRNA.

1985 • 17 citations

Enzyme Markers for the Presence of Circulating Interferon: 2-5A Synthetase in Blood Lymphocytes and Protein Kinase in Platelet-Rich Plasma

1984 • 14 citations

Double-stranded RNA dependent protein kinase (s) in rabbit reticulocyte lysates analogous to kinase from interferon-treated cells

1980 • 12 citations