Lung pathology: the molecular genetics of non-small cell lung cancer

p53 Mutations in Human Cancers

1991 • 8,133 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

ras GENES

1987 • 3,818 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

p53 function and dysfunction

1992 • 1,918 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

A Randomized Trial Comparing Preoperative Chemotherapy Plus Surgery with Surgery Alone in Patients with Non-Small-Cell Lung Cancer

1994 • 1,244 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1983 • 921 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

1985 • 652 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

GENETICS OF HUMAN CANCER

1986 • 565 citations

Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

1991 • 556 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung.

1993 • 482 citations

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

1985 • 472 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

1988 • 458 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Specific Chromosome Defect Associated with Human Small-Cell Lung Cancer: Deletion 3p(14-23)

1982 • 450 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

p185neu expression in human lung adenocarcinomas predicts shortened survival.

1990 • 440 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.

1989 • 398 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Clinical significance of ras oncogene activation in human lung cancer

1993 • 361 citations

Prognostic significance of p53 mutations and 3p deletions in primary, resected non-small cell lung cancer

1995 • 333 citations

Molecular Analysis of the Short Arm of Chromosome 3 in Small-Cell and Non-Small-Cell Carcinoma of the Lung

1987 • 331 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.

1992 • 299 citations

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

1992 • 298 citations

Human small-cell lung cancers show amplification and expression of the N-myc gene.

1986 • 293 citations

p53 Mutations in non-small cell lung cancer in Japan: Association between mutations and smoking

1992 • 280 citations

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

1992 • 269 citations

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

1992 • 257 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

Gene Amplification of c- myc and N- myc in Small Cell Carcinoma of the Lung

1986 • 253 citations

ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.

1991 • 249 citations

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

1988 • 247 citations

Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.

1989 • 237 citations

Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer

1990 • 233 citations

Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.

1990 • 232 citations

High frequency of retinoic acid receptor beta abnormalities in human lung cancer.

1991 • 216 citations

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

1993 • 207 citations

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

1991 • 207 citations

Three distinct regions involved in 3p deletion in human lung cancer

1993 • 200 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung

1992 • 188 citations

K‐ ras oncogene activation in lung adenocarcinomas from former smokers evidence that K‐ ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 187 citations

Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma

1991 • 185 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

p53 mutations in human lung tumors.

1992 • 177 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

K-ras oncogene activation in lung adenocarcinomas from former smokers evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 169 citations

ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.

1992 • 168 citations

Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas

1992 • 167 citations

Somatic allelic deletion of nm23 in human cancer.

1991 • 159 citations

Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer

1991 • 158 citations

Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients

1994 • 156 citations

Allelotype of non-small cell lung carcinoma - Comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma

1993 • 149 citations

Progressing toward a molecular description of colorectal cancer development

1992 • 148 citations

Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.

1993 • 147 citations

The biology of lung cancer.

1993 • 143 citations

K‐ras mutations in human adenocarcinoma of the lung: Association with smoking and occupational exposure to asbestos

1993 • 140 citations

Expression of epidermal growth factor receptor (EGF-R) in human lung tumours

1986 • 140 citations

Frequent loss of chromosome 9 in human primary non-small cell lung cancer.

1994 • 136 citations

Cytogenetics of non‐small cell lung cancer: Analysis of consistent non‐random abnormalities

1990 • 129 citations

Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group.

1993 • 128 citations

Structural differences between a ras oncogene protein and the normal protein

1989 • 125 citations

Amplification of protooncogenes in surgical specimens of human lung carcinomas

1990 • 121 citations

Epidermal growth factor receptor expression in human lung cancer cell lines

1989 • 120 citations

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1993 • 118 citations

High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22.

1989 • 117 citations

Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.

1992 • 116 citations

The Molecular Biology of Lung Cancer Pathogenesis

1993 • 116 citations

Tumourigenesis associated with the p53 tumour suppressor gene

1993 • 115 citations

Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics

1990 • 111 citations

Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.

1992 • 107 citations

Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer.

1992 • 106 citations

The ninth Gordon Hamilton-Fairley memorial lecture: Hereditary cancers: clues to mechanisms of carcinogenesis

1989 • 105 citations

Prognostic significance of the expression ofras oncogene product in non-small cell lung cancer

1992 • 98 citations

Expression of epidermal and nerve growth factor receptors and soft agar growth factor production by human lung cancer cells.

1981 • 97 citations

High levels of NM23‐H1 and NM23‐H2 messenger RNA in human squamous‐cell lung carcinoma are associated with poor differentiation and advanced tumor stages

1993 • 95 citations

A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.

1993 • 93 citations

Three distinct regions involved in 3P deletion in human lung cancer.

1993 • 92 citations

Overexpression of the p53 Tumor Suppressor Gene Product in Primary Lung Adenocarcinomas Is Associated with Cigarette Smoking

1993 • 90 citations

Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes

1990 • 86 citations

Implication of RARB in Epidermoid (Squamous) Lung Cancer

1991 • 83 citations

Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes

1989 • 82 citations

Suppressor gene alterations in the colorectal adenoma-carcinoma sequence

1992 • 81 citations

Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value

1992 • 75 citations

Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors.

1988 • 74 citations

Deletion mapping of the short arm of chromosome 8 in non‐small cell lung carcinoma

1993 • 73 citations

Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma

1990 • 71 citations

Abnormalities of protooncogenes in non-small cell lung cancer. Correlations with tumor type and clinical characteristics

1987 • 67 citations

Dominant Oncogenes and Tumor Suppressor Genes in the Pathogenesis of Lung Cancer

1990 • 65 citations

Infrequent mutations of the p53 gene in pulmonary carcinoid tumors.

1993 • 65 citations

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.

1991 • 64 citations

Clinicopathological Significance of Nuclear Accumulation of Tumor Suppressor Gene p53 Product in Primary Lung Cancer

1992 • 57 citations

Loss of genes on the short arm of chromosome 11 in human lung carcinomas.

1987 • 57 citations

Molecular markers for the diagnosis and prognosis of lung cancer

1992 • 54 citations

Tumor metastasis and nm23: current concepts.

1991 • 52 citations

Correlation of L‐myc RFLP with metastasis, prognosis and multiple cancer in lung‐cancer patients

1992 • 51 citations

Inhibition of Human Lung Cancer Cell Line Growth by an Anti-p185^HER2 Antibody

1993 • 50 citations

The Molecular Genetics of Lung Cancer

2008 • 50 citations

Gene Amplification in Human Lung Cancer: ThemycFamily Genes and Other Proto-oncogenes and Growth Factor Genes

1990 • 47 citations

Molecular deletion of 9p sequences in non‐small cell lung cancer and malignant mesothelioma

1993 • 47 citations

The ras gene family in human non-small-cell lung cancer.

1992 • 46 citations

Allelic loss on the short arm of chromosome 11 in non‐small‐cell lung cancer

1991 • 46 citations

Studies of the L-myc DNA polymorphism and relation to metastasis in Norwegian lung cancer patients

1990 • 45 citations

Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer

1989 • 44 citations

myc Family gene abnormality in lung cancers and its relation to xenotransplantability

1989 • 40 citations

A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer

1993 • 40 citations

PCR-based RFLP analysis allows genotyping of the short arm of chromosome 3 in small biopsies from patients with lung cancer

1992 • 39 citations

Loss of heterozygosity at the c-raf locus in small cell lung carcinoma

1990 • 37 citations

Molecular genetics of lung cancer

1991 • 36 citations

Incidence ofras oncogene activation in lung carcinomas in Hong Kong

1992 • 32 citations

Relationship of H-ras-1, L-myc, and p53 polymorphisms with lung cancer risk and prognosis.

1992 • 32 citations

Role of raf oncogenes in lung carcinogenesis

1988 • 32 citations

Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer

1993 • 28 citations

Primary lung cancer: characterization and survival of 1024 patients treated in a single institution

1990 • 25 citations

Detection and Sequencing of p53 Gene Mutations in Bronchial Biopsy Samples in Patients With Lung Cancer

1993 • 25 citations

Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan

1992 • 24 citations

The molecular genetics of human lung cancer

1989 • 24 citations

Loss of heterozygosity for genes on 11p and the clinical course of patients with lung carcinoma

1991 • 24 citations

myc family DNA amplification in tumors and tumor cell lines from patients with small-cell lung cancer.

1992 • 23 citations

Oncogenes and onco-suppressor genes in lung cancer

1993 • 22 citations

myc Genes and their deregulation in lung cancer

1990 • 17 citations

Genomic components of carcinogenesis

1993 • 17 citations

DNA alterations at proto-oncogene loci and their clinical significance in operable non-small cell lung cancer

1990 • 17 citations

Amplification and rearrangement of L-myc in human small-cell lung cancer

1992 • 16 citations

Abnormalities of retinoblastoma gene structure in human lung tumors

1993 • 12 citations

Constitutive expression of multiple messenger rna forms of the c jun oncogene in human lung cancer cell lines

1988 • 11 citations

Recessive Oncogenes in Lung Cancer

1990 • 9 citations

Address Before the Section of Mathematics and Physics

1906 • 5 citations