Wild-type p53 activates transcription in vitro

p53 Mutations in Human Cancers

1991 • 8,133 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

1989 • 216 citations

The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses

1990 • 200 citations

The MCK enhancer contains a p53 responsive element.

1991 • 170 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

A potential transcriptional activation element in the p53 protein.

1990 • 129 citations

Formation of stable p53 homotetramers and multiples of tetramers

1992 • 110 citations

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.

1990 • 105 citations

Transcriptional Regulation of c-fos

1988 • 35 citations

A tumor promoting phorbol ester, TPA, enhances polyomavirus DNA replication by activating the function of the viral enhancer.

1990 • 34 citations

Serum response factor affects preinitiation complex formation by TFIID in vitro.

1991 • 27 citations