Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

p53 Mutations in Human Cancers

1991 • 8,133 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Artificial transmutation of the gene

1996 • 966 citations

Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction.

1988 • 748 citations

SAMPLE PREPARATION FROM PARAFFIN-EMBEDDED TISSUES

1990 • 565 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

1991 • 345 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Gene Amplification of c- myc and N- myc in Small Cell Carcinoma of the Lung

1986 • 253 citations

Expression of p53 in premalignant and malignant squamous epithelium.

1991 • 237 citations

Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.

1988 • 191 citations

Health Risks of Radon and Other Internally Deposited Alpha-Emitters (Beir IV)

1988 • 190 citations

Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer.

1991 • 185 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

1990 • 127 citations

myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens.

1991 • 103 citations

Lung Cancer Mortality and Exposure to Radon Progeny in a Cohort of New Mexico Underground Uranium Miners

1991 • 93 citations

Possible association between mutant frequency in peripheral lymphocytes and domestic radon concentrations

1991 • 74 citations

Association between the cellular p53 and the adenovirus 5 E1B-55kd proteins reduces the oncogenicity of Ad-transformed cells.

1990 • 68 citations

Expression from the murine p53 promoter is mediated by factor binding to a downstream helix-loop-helix recognition motif.

1991 • 67 citations

Radon Progeny Exposure and Lung Cancer Risk in New Mexico U Miners

1989 • 48 citations

Potential lung cancer risk from indoor radon exposure

1990 • 40 citations

Review of Radon and Lung Cancer Risk

1990 • 36 citations

Point mutation of the p53 gene resulting in splicing inhibition in small cell lung carcinoma

1990 • 34 citations

Comparison of radon‐daughter‐induced effects in repair‐proficient and repair‐deficient cho cell lines

1990 • 13 citations

Potential lung cancer risk from indoor radon exposure

1991 • 2 citations