K-ras oncogene activation in lung adenocarcinomas from former smokers evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

ras GENES

1987 • 3,818 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

1992 • 703 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Mutational Activation of the K-rasOncogene

1987 • 542 citations

A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides

1986 • 351 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

Ki-ras oncogene activation in preinvasive pancreatic cancer

1992 • 250 citations

v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis

1986 • 244 citations

Prognostic significance of the expression ofras oncogene product in non-small cell lung cancer

1992 • 98 citations

DNA base changes in benzo [α]pyrene diol epoxide-induced dihydrofolate reductase mutants of Chinese hamster ovary cells

1990 • 53 citations

A Rapid and Simple Procedure for the Routine Detection of ras Point Mutations in Formalin-Fixed, Paraffin-Embedded Tissues

1992 • 44 citations

Clinical aspects of lung cancer

1990 • 43 citations

Incidence ofras oncogene activation in lung carcinomas in Hong Kong

1992 • 32 citations

Lung cancer: Epidemiology and risk factors

1990 • 18 citations