Gene Amplification of c- myc and N- myc in Small Cell Carcinoma of the Lung

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

1981 • 1,611 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1983 • 921 citations

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

1985 • 821 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

Translocations Among Antibody Genes in Human Cancer

1983 • 736 citations

A highly polymorphic locus in human DNA.

1980 • 716 citations

Transposition and amplification of oncogene-related sequences in human neuroblastomas

1983 • 711 citations

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

1985 • 652 citations

Gene amplification in cultured animal cells

1984 • 639 citations

onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

1982 • 638 citations

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

1982 • 630 citations

Viral oncogenes

1985 • 605 citations

GENE AMPLIFICATION

1984 • 580 citations

Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.

1985 • 472 citations

Expression and amplification of the N-myc gene in primary retinoblastoma

1984 • 451 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells

1984 • 400 citations

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?

1984 • 322 citations

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture

1985 • 288 citations

Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals

1984 • 212 citations

Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.

1982 • 193 citations

The clinical behavior of „mixed” small cell/large cell bronchogenic carcinoma compared to „pure” small cell subtypes

1982 • 181 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.

1986 • 173 citations

Patterns of the early, gross chromosomal changes in malignant human gliomas

2008 • 131 citations

Chromosomal banding patterns in human large bowel cancer

1981 • 130 citations

Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.

1983 • 122 citations

Gene amplification in human neuroblastomas: Basic mechanisms and clinical implications

1986 • 119 citations

Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.

1985 • 117 citations

Karyotypic characterization of established cell lines and short-term cultures of human lung cancers

1985 • 94 citations

Gene amplification: an example of accelerated evolution in tumorigenic cells.

1985 • 94 citations

GENOMIC ALTERATIONS INVOLVING THE C-MYC PROTO-ONCOGENE LOCUS DURING THE EVOLUTION OF A CASE OF CHRONIC GRANULOCYTIC LEUKAEMIA

1984 • 91 citations

Amplification units containing human N-myc and c-myc genes.

1986 • 78 citations

Amplification of cellular oncogenes in cancer cells

1985 • 76 citations

Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer

1985 • 74 citations

Amplification, Expression and Rearrangement of c-myc and N-myc Oncogenes in Human Lung Cancer

1984 • 66 citations

Microchromosomes in human preleukemia and leukemia

1971 • 46 citations

Expression of the amplified domain in human neuroblastoma cells.

1984 • 41 citations

Cytogenetics of Human Small Cell Lung Cancer

1985 • 16 citations