Role of HLA and T lymphocytes in the immune response

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Evolutionary Rate at the Molecular Level

1968 • 3,608 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

Histocompatibility-Linked Immune Response Genes

1972 • 1,194 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

1989 • 923 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Role of MHC Gene Products in Immune Regulation

1981 • 705 citations

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation

1991 • 687 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Map of the human MHC

1993 • 585 citations

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

1987 • 515 citations

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1985 • 509 citations

Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.

1985 • 492 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Close Association of HLA-Bw51 With Behcet's Disease

1982 • 468 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

1984 • 433 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Guilt by association: HLA-B27 and ankylosing spondylitis

1990 • 418 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

T Cell Selection in the Thymus

1988 • 405 citations

Structure and expression of the three MHC-linked HSP70 genes

1990 • 397 citations

Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule.

1990 • 393 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

Second proteasome-related gene in the human MHC class II region

1991 • 348 citations

Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

1992 • 344 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

1985 • 340 citations

Nomenclature for factors of the HLA system, 1991

1992 • 337 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer

1992 • 322 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.

1984 • 291 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINS

1988 • 277 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Birdshot Retinochoroidopathy

1980 • 271 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Sex, Sex Inheritance and Sex Determination in Paramecium Aurelia

1937 • 262 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

A new human HLA class II-related locus, DM

1991 • 251 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

A New Cluster of Genes Within the Human Major Histocompatibility Complex

1989 • 247 citations

HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.

1988 • 239 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

1987 • 237 citations

Allelic variants of the human putative peptide transporter involved in antigen processing.

1992 • 235 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Intracellular transport of MHC class II molecules

1992 • 222 citations

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.

1989 • 220 citations

Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2

1993 • 217 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans

1987 • 212 citations

HLA class II allelic variation and susceptibility to pemphigus vulgaris.

1988 • 211 citations

Biology of the Laboratory Mouse.

1941 • 200 citations

Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.

1990 • 200 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

1992 • 190 citations

HLA class II nucleotide sequences, 1992

1992 • 185 citations

HL-A5 AND BEHCET'S DISEASE

1973 • 184 citations

Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.

1989 • 183 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Genomic structure and function in the MHC

1993 • 179 citations

Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.

1991 • 173 citations

Evolution at the molecular level

1991 • 169 citations

Cell biology of antigen presentation

1993 • 166 citations

Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.

1989 • 164 citations

Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen.

1986 • 164 citations

Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

1989 • 156 citations

The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.

1985 • 149 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture

1984 • 147 citations

A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain.

1990 • 141 citations

HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-RFLP and the strong association with DRB1*0405 and DRB1*0410.

1994 • 141 citations

In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells.

1992 • 134 citations

Which came first, MHC class I or class II?

1991 • 132 citations

How many controls?

1976 • 129 citations

Invariant chain influences the immunological recognition of MHC class II molecules

1990 • 127 citations

The Detection of Antigenic Differences in Mouse Erythrocytes by the Employment of Immune Sera

1936 • 127 citations

Megabase-Scale Mapping of the HLA Gene Complex by Pulsed Field Gel Electrophoresis

1987 • 126 citations

Working principles in the immune system implied by the "peptidic self" model.

1987 • 115 citations

Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells

1989 • 113 citations

Binding to Ia protects an immunogenic peptide from proteolytic degradation.

1989 • 113 citations

Autoimmune myocarditis: a paradigm of post-infection autoimmune disease

1988 • 112 citations

T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.

1984 • 108 citations

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 • 106 citations

Anti-CD4 mediates clonal anergy during transplantation tolerance induction.

1991 • 104 citations

Intrathymic presentation of circulating non-major histocompatibility complex antigens

1984 • 102 citations

Haplotypic variation of the transporter associated with antigen processing (TAP) genes and their extension of HLA class II region haplotypes

1993 • 100 citations

HLA class I nucleotide sequences, 1992

1992 • 96 citations

HLA DISEASE ASSOCIATIONS: Models for Insulin Dependent Diabetes Mellitus and the Study of Complex Human Genetic Disorders

1988 • 94 citations

Intracellular traffic and antigen processing

1989 • 92 citations

Genomic polymorphism, recombination, and linkage disequilibrium in human major histocompatibility complex-encoded antigen-processing genes.

1992 • 92 citations

Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

1989 • 91 citations

Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.

1986 • 90 citations

The thymic compartment responsible for positive selection of CD4⁺ T cells

1992 • 89 citations

DETERMINATION OF SIGNIFICANT RELATIVE RISKS AND OPTIMAL SAMPLING PROCEDURES IN PROSPECTIVE AND RETROSPECTIVE COMPARATIVE STUDIES OF VARIOUS SIZES

1977 • 86 citations

Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex

1982 • 85 citations

T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer.

1990 • 80 citations

Frequency and surface phenotype of human T lymphocytes producing interleukin 2. Analysis by limiting dilution and cell cloning

1985 • 75 citations

A Critical Role for Conserved Residues in the Cleft of HLA-A2 in Presentation of a Nonapeptide to T Cells

1992 • 72 citations

Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis.

1988 • 69 citations

Report of the committee on the genetic constitution of chromosomes 5 and 6

1987 • 67 citations

Recognition Requirements for the Activation, Differentiation and Function of T‐Helper Cells Specific for Class I MHC Alloantigens

1987 • 66 citations

Association of birdshot retinochoroidopathy and HLA-A29 antigen

1990 • 66 citations

HLA CLASS II NUCLEOTIDE SEQUENCES, 1991

1991 • 63 citations

Association of HLA‐B51 and lack of association of class II alleles with Behcet's disease

1992 • 61 citations

Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51.

1992 • 61 citations

Phospholipids enhance the binding of peptides to class II major histocompatibility molecules.

1990 • 56 citations

Human helper T-cell clones that recognize different influenza hemagglutinin determinants are restricted by different HLA-D region epitopes

1984 • 55 citations

A gene in the H-2S : H-2D interval of the major histocompatibility complex which is transcribed in B cells and macrophages

1987 • 54 citations

Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha.

1985 • 48 citations

AN ESTIMATE OF THE NUMBER OF HISTOCOMPATIBILITY LOCI IN THE TELEOST XIPHOPHORUS MACULATUS

1964 • 44 citations

Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation.

1990 • 40 citations

The Cell Biology of Antigen Processing

1991 • 39 citations

Molecular biology of self-incompatibility in plants

1986 • 35 citations

The mechanism of evolution

1960 • 32 citations

RFLP analysis in the TNF-beta gene and the susceptibility to alloreactive NK cells in Behçet's disease.

1992 • 31 citations

Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (Lmp-2).

1993 • 31 citations

Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. III. Analysis of regulatory cells suppressing the induction of thyroiditis

1990 • 28 citations

Specific immunorecognition by histocompatibility markers: The original polymorphic system of immunoreactivity characteristic of all multicellular animals

1977 • 26 citations

Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigens.

1991 • 25 citations

Cosmid clones in the HLA-DZ and -DP subregions

1990 • 18 citations

Isolation of a functional antigen-Ia complex.

1990 • 17 citations

Transferability of immune plasma and pronephric cells in isogeneic, allogeneic and xenogeneic transfer systems in crucian carp

1987 • 16 citations

Recognition of alloantigen by cytotoxic T cell precursors is independent of the function of Ia+ cells.

1985 • 10 citations

Tolerogenic ability of thymocytes in organ-cultured thymus lobes.

1991 • 9 citations

[Immunogenetic mechanism of Behçet's disease].

1991 • 8 citations

Major histocompatibility complex-peptide interactions

1989 • 7 citations