Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

The Immune System

2000 • 1,647 citations

IMMUNOLOGICAL FUNCTION OF THE THYMUS

1961 • 1,359 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Immunocytochemistry: 2nd edn

1980 • 880 citations

The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation

1984 • 718 citations

Immunology: The ins and outs of antigen processing and presentations

1986 • 498 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression

1986 • 395 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse

1984 • 323 citations

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1985 • 322 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.

1983 • 280 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Aberrant expression of Class II major histocompatibility complex molecules by B cells and hyperexpression of Class I major histocompatibility complex molecules by insulin containing islets in Type 1 (insulin-dependent) diabetes mellitus

1987 • 243 citations

Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

1986 • 212 citations

Function and Specificity of T Cell Subsets in the Mouse

1987 • 208 citations

Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitus

1987 • 205 citations

Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells.

1984 • 176 citations

Germline and somatic mosaicism in transgenic mice

1986 • 175 citations

The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.

1986 • 153 citations

Expression of marine H–2Kb histocompatibility antigen in cells transformed with cloned H–2 genes

1982 • 101 citations

Class I histocompatibility antigens and insulin receptors: evidence for interactions.

1986 • 83 citations

Regulation of human insulin gene expression in transgenic mice

1986 • 82 citations

Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light-microscopic and ultrastructural observations of pancreatic islets of Langerhans.

1982 • 76 citations

Interferon-γ Enhances the Expression of the Major Histocompatibility Class I Antigens on Mouse Pancreatic Beta Cells

1985 • 75 citations

Islet Cytotoxicity of Interleukin 1: Influence of Culture Conditions and Islet Donor Characteristics

1987 • 72 citations

Regulation of MHC Protein Expression in Pancreatic β-Cells by Interferon-γ and Tumor Necrosis Factor-α

1988 • 67 citations

Expression of major histocompatibility antigens on pancreatic islet cells.

1981 • 60 citations

Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.

1988 • 60 citations

Reovirus Infection Enhances Expression of Class I MHC Proteins on Human β-Cell and Rat RINm5F cell

1988 • 42 citations

Insulin binding to human B lymphoblasts is a function of HLA haplotype.

1987 • 41 citations

Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb.

1986 • 31 citations