Chronic lymphocytic leukemia: revelations from the B-cell receptor

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

ZAP-70 Expression as a Surrogate for Immunoglobulin-Variable-Region Mutations in Chronic Lymphocytic Leukemia

2003 • 1,366 citations

Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia

2001 • 1,110 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells

2001 • 934 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

1994 • 818 citations

Prevention of Arthritis by Interleukin 10–producing B Cells

2003 • 816 citations

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

2003 • 815 citations

The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

2002 • 530 citations

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers

2002 • 522 citations

Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells

1999 • 495 citations

A Reversible Defect in Natural Killer T Cell Function Characterizes the Progression of Premalignant to Malignant Multiple Myeloma

2003 • 412 citations

The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

2002 • 408 citations

Chronic Lymphocytic Leukemic B Cells But Not Normal B Cells Are Rescued From Apoptosis by Contact With Normal Bone Marrow Stromal Cells

1998 • 401 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

B Cell Chronic Lymphocytic Leukemia: Lessons Learned from Studies of the B Cell Antigen Receptor

2003 • 377 citations

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

2001 • 350 citations

Lipid rafts and B-cell activation

2002 • 349 citations

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

2003 • 330 citations

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vλ2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope

2003 • 318 citations

Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

1996 • 309 citations

Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses

2003 • 302 citations

Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia.

1989 • 290 citations

Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA

1980 • 269 citations

The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression

2003 • 268 citations

Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22

2002 • 266 citations

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

2002 • 242 citations

Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.

1989 • 239 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies

1990 • 222 citations

Role of the microenvironment in chronic lymphocytic leukaemia

2003 • 202 citations

The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia

2000 • 195 citations

Bryostatin and CD40‐ligand enhance apoptosis resistance and induce expression of cell survival genes in B‐cell chronic lymphocytic leukaemia

1999 • 189 citations

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

2002 • 188 citations

In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells

2000 • 183 citations

Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations

2003 • 183 citations

Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)

1999 • 180 citations

CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes

2003 • 155 citations

Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia.

1997 • 154 citations

Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone

2003 • 150 citations

High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia

2003 • 150 citations

The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis

1999 • 149 citations

Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors

1992 • 143 citations

Proliferation centres in B‐cell malignant lymphoma, lymphocytic (B‐CLL): an immunophenotypic study

1994 • 139 citations

Somatic hypermutation of the B cell receptor genesB29(Igβ, CD79b) andmb1(Igα, CD79a)

2003 • 133 citations

The occurrence and significance of V gene mutations in B cell—Derived human malignancy

2001 • 124 citations

Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

2003 • 119 citations

The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms

2000 • 112 citations

An Alternatively Spliced Form of CD79b Gene May Account for Altered B-Cell Receptor Expression in B-Chronic Lymphocytic Leukemia

1999 • 111 citations

Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin VHDJH Gene Diversification

2002 • 98 citations

Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia

2003 • 97 citations

Chronic B cell malignancies and bone marrow microenvironment

2002 • 95 citations

B-cell superantigens

1997 • 91 citations

Antigen-Stimulated Dissociation of BCR mIg from Ig-α/Ig-β

1999 • 90 citations

Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia

1983 • 90 citations

Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

2003 • 83 citations

Integrin function in chronic lymphocytic leukemia

1996 • 79 citations

Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment.

1993 • 78 citations

Regulation of CD26/DPPIV gene expression by interferons and retinoic acid in tumor B cells

2000 • 72 citations

Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes

2001 • 70 citations

Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia

1985 • 66 citations

Stimulation of B-chronic lymphocytic leukemia cells by murine fibroblasts, IL-4, anti-CD40 antibodies, and the soluble CD40 ligand.

1997 • 62 citations

The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis

2002 • 53 citations

In vitro activation of murine antigen-specific memory B cells by a T-dependent antigen.

1986 • 51 citations

Chronic lymphocytic leukemia B cells inhibit spontaneous Ig production by autologous bone marrow cells: role of CD95-CD95L interaction

2000 • 50 citations

Defective assembly of the B‐cell receptor chains accounts for its low expression in B‐chronic lymphocytic leukaemia

2002 • 42 citations

Transmodulation of BCR Signaling by Transduction- Incompetent Antigen Receptors: Implications for Impaired Signaling in Anergic B Cells

2002 • 40 citations

Analysis of the B-Cell Receptor B29 (CD79b) Gene in Familial Chronic Lymphocytic Leukemia

1999 • 36 citations

Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism

2003 • 35 citations

Aberrant B cell receptor signaling fromB29(Igβ,CD79b) gene mutations of chronic lymphocytic leukemia B cells

2000 • 35 citations

Gene Expression Dynamics during Germinal Center Transit in B Cells

2003 • 33 citations

The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing

1995 • 26 citations

The immune response to phichi174 in man. IV. Primary and secondary antibody production in patients with chronic lymphatic leukaemia.

1975 • 20 citations

Alternatively spliced forms of Igα and Igβ prevent B cell receptor expression on the cell surface

2002 • 19 citations

Alternatively spliced forms of Igα and Igβ prevent B cell receptor expression on the cell surface

2002 • 18 citations

Cytokine expression in B-CLL in relation to disease progression andin vitro activation

1999 • 13 citations

Stability of the B cell antigen receptor modulates its signaling and antigen-targeting functions

2002 • 5 citations