Chronic Lymphocytic Leukemic B Cells But Not Normal B Cells Are Rescued From Apoptosis by Contact With Normal Bone Marrow Stromal Cells

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Role of beta 1 and beta 2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma.

1992 • 388 citations

Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

1992 • 366 citations

Special Article: Chronic Lymphocytic Leukemia—an Accumulative Disease of Immunologically Incompetent Lymphocytes

1967 • 347 citations

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

1994 • 314 citations

Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

1996 • 309 citations

Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome.

1996 • 294 citations

Cells and Molecules that Regulate B Lymphopoiesis in Bone Marrow

1989 • 272 citations

Spontaneous programmed death (apoptosis) of B‐chronic lymphocytic leukaemia cells following their culture in vitro

1989 • 260 citations

Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia.

1993 • 258 citations

Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis

1992 • 245 citations

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.

1991 • 189 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

Apoptosis Overview Emphasizing the Role of Oxidative Stress, DNA Damage and Signal- Transduction Pathways

1995 • 175 citations

Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX.

1996 • 165 citations

Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells.

1994 • 162 citations

Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells

1994 • 160 citations

The hematopoietic microenvironment

1991 • 121 citations

Interferon‐alpha up‐regulates bcl‐2 expression and protects B‐CLL cells from apoptosis in vitro and in vivo

1994 • 109 citations

Phenotypic and functional characteristics of human newborns' B lymphocytes.

1990 • 104 citations

Involvement of integrins in cell survival

1995 • 96 citations

Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms

1993 • 92 citations

B lymphocyte precursors and myeloid progenitors survive in diffusion chamber cultures but B cell differentiation requires close association with stromal cells

1987 • 85 citations

Interleukin-13 inhibits interleukin-2-induced proliferation and protects chronic lymphocytic leukemia B cells from in vitro apoptosis

1996 • 82 citations

In leukaemic CD5⁺ B cells the expression of BCL‐2 gene family is shifted toward protection from apoptosis

1996 • 81 citations

Integrin function in chronic lymphocytic leukemia

1996 • 79 citations

Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production

1993 • 65 citations

The nature of the B lymphocyte in B-chronic lymphocytic leukemia.

1993 • 58 citations

Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4

1994 • 49 citations

Maturation-dependent adhesion of human B cell precursors to the bone marrow microenvironment.

1990 • 47 citations

Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma.

1996 • 46 citations

Human B-lymphopoiesis is supported by bone marrow-derived stromal cells.

1991 • 45 citations

Culture of human fetal B-cell precursors on bone marrow stroma maintains highly proliferative CD20dim cells

1993 • 44 citations

Apoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells.

1995 • 39 citations

Stromal cells regulate bcl-2 and bax expression in pro-B cells.

1996 • 30 citations

Engraftment of human chronic lymphocytic leukemia cells in SCID mice: in vivo and in vitro studies.

1996 • 28 citations

Surface Phenotype and Adhesion Activity of B-Cell Chronic Lymphoid Leukemias

1993 • 18 citations

Leukaemic CD5 + B‐cell apoptosis: co‐incidence of cell death and DNA fragmentation with reduced bcl‐2 expression

1996 • 14 citations