Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

1996 • 1,906 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Cancer statistics, 1995

1995 • 1,434 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1

2000 • 720 citations

Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses

1998 • 656 citations

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 • 617 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather

1999 • 408 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

Chronic Lymphocytic Leukemic B Cells But Not Normal B Cells Are Rescued From Apoptosis by Contact With Normal Bone Marrow Stromal Cells

1998 • 401 citations

Mcl-1 deficiency results in peri-implantation embryonic lethality

2000 • 382 citations

The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction

2002 • 376 citations

The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

1999 • 358 citations

Special Article: Chronic Lymphocytic Leukemia—an Accumulative Disease of Immunologically Incompetent Lymphocytes

1967 • 347 citations

Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

1996 • 309 citations

B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL

1991 • 298 citations

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

1995 • 296 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

Spontaneous programmed death (apoptosis) of B‐chronic lymphocytic leukaemia cells following their culture in vitro

1989 • 260 citations

IL-6 up-regulates Mcl-1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway

1999 • 249 citations

Regulation of Bcl-xL: a little bit of this and a little bit of STAT

2000 • 235 citations

B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL

1991 • 218 citations

B-chronic lymphocytic leukemia: a malignancy of anti-self B cells

1996 • 212 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

Advances in the biology and treatment of B-cell chronic lymphocytic leukemia

1995 • 198 citations

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.

1991 • 189 citations

Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils

2001 • 180 citations

Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell–derived factor-1– and CD106 (VCAM-1)–dependent mechanism

2001 • 173 citations

Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.

1994 • 163 citations

Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells

1994 • 160 citations

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

1998 • 155 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NFkappaB, STAT and AP1 transcription factor families.

2001 • 127 citations

Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes.

1994 • 124 citations

Detection of Multiple Antigens on Western Blots

1996 • 103 citations

Interleukin-13 in Combination With CD40 Ligand Potently Inhibits Apoptosis in Human B Lymphocytes: Upregulation of Bcl-xL and Mcl-1

1997 • 81 citations

Biology of Chronic Lymphocytic Leukemia

2000 • 76 citations

Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055

2000 • 72 citations

Stimulation of germinal center B lymphocyte proliferation by an FDC-like cell line, HK.

1995 • 68 citations

Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia

1985 • 66 citations

Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: evidence for a novel mechanism of regulating Bcl-2 family protein function.

1995 • 65 citations

Reversal of EBV Immortalization Precedes Apoptosis in IL-6–Induced Human B Cell Terminal Differentiation

1997 • 61 citations

Interleukin-6 dimers produced by endothelial cells inhibit apoptosis of B-chronic lymphocytic leukemia cells

2001 • 59 citations

Modulating apoptosis pathways in low-grade B-cell malignancies using biological response modifiers

2002 • 49 citations

Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma.

1996 • 46 citations

Establishment of a follicular lymphoma cell line (FLK-1) dependent on follicular dendritic cell-like cell line HK

2001 • 45 citations

Follicular Dendritic Cells in Non-Hodgkin's Lymphomas

1994 • 38 citations

Chronic lymphoproliferative disorders

1995 • 33 citations

Reduced susceptibility to apoptosis correlates with kinetic quiescence in disease progression of chronic lymphocytic leukaemia

2001 • 32 citations

Quiescent memory B cells in human peripheral blood co-express bcl-2 and bcl-xL anti-apoptotic proteins at high levels

1998 • 20 citations

Chronic Lymphoproliferative Disorders

2008 • 5 citations