The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

2000 • 1,253 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

2000 • 867 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Type 1 T regulatory cells

2001 • 829 citations

Infectious immunological tolerance.

1971 • 811 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Generation of Human CD8 T Regulatory Cells by CD40 Ligand–activated Plasmacytoid Dendritic Cells

2002 • 659 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells

2002 • 632 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Infectious Tolerance

2002 • 614 citations

IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells

2001 • 610 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells

2000 • 560 citations

The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

2001 • 549 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

2002 • 528 citations

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

2002 • 501 citations

Differentiation of T Regulatory Cells by Immature Dendritic Cells

2001 • 500 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration

2001 • 458 citations

CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity

2002 • 455 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1994 • 413 citations

Immature, but not inactive: the tolerogenic function of immature dendritic cells

2002 • 389 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma

1997 • 384 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases

2002 • 356 citations

Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody

2002 • 340 citations

Expression cloning and characterization of a human IL-10 receptor.

1994 • 327 citations

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

2002 • 324 citations

The interleukin-10 family of cytokines

2002 • 323 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

2002 • 267 citations

Human allograft acceptance is associated with immune regulation

2000 • 261 citations

TGF‐β Latency: Biological Significance and Mechanisms of Activation

1997 • 261 citations

Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells

2001 • 246 citations

Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells

2002 • 246 citations

Regulating the Immune Response to Transplants

2001 • 242 citations

Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses

2000 • 241 citations

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

1998 • 225 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity

2001 • 218 citations

Interleukin‐10 expressed at early tumour sites induces subsequent generation of CD4⁺ T‐regulatory cells and systemic collapse of antitumour immunity

2001 • 206 citations

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

1998 • 205 citations

Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.

1999 • 195 citations

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

2002 • 194 citations

Immunosuppression by CD4⁺regulatory T cells induced by chronic retroviral infection

2001 • 189 citations

Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease

2001 • 181 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Regulation of TGF-β Response During T Cell Activation Is Modulated by IL-10

2001 • 173 citations

Treatment of Experimental (Trinitrobenzene Sulfonic Acid) Colitis by Intranasal Administration of Transforming Growth Factor (Tgf)-β1 Plasmid

2000 • 166 citations

Negative co-receptors on lymphocytes

2002 • 164 citations

Role for granulocyte colony–stimulating factor in the generation of human T regulatory type 1 cells

2002 • 159 citations

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

2000 • 158 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 154 citations

Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis

2000 • 152 citations

CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens.

1997 • 146 citations

Designer dendritic cells for tolerance induction: guided not misguided missiles

2001 • 132 citations

Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

2000 • 126 citations

Activated Self-MHC-Reactive T Cells Have the Cytokine Phenotype of Th3/T Regulatory Cell 1 T Cells

2000 • 124 citations

The role of CD4⁺ T‐cell subsets in determining transplantation rejection or tolerance

2001 • 120 citations

Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells

2002 • 116 citations

Physical and Functional Interaction between GATA-3 and Smad3 Allows TGF-β Regulation of GATA Target Genes

2002 • 98 citations

Differentiation of Regulatory T Cells 1 Is Induced by CD2 Costimulation

2001 • 97 citations

Quantitative and Qualitative Assessment of Human Immunodeficiency Virus Type 1 (HIV‐1)–Specific CD4⁺T Cell Immunity togagin HIV‐1–Infected Individuals with Differential Disease Progression: Reciprocal Interferon‐γ and Interleukin‐10 Responses

2001 • 88 citations

Secretion of Cytokines, Histamine and Leukotrienes in Chronic Urticaria

2002 • 83 citations

On the ontogeny and physiology of regulatory T cells

2001 • 82 citations

T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive, IL-10-producing T cell population with infectious capacity.

1997 • 81 citations

Pepsin-Resistant 16-kD Buckwheat Protein Is Associated with Immediate Hypersensitivity Reaction in Patients with Buckwheat Allergy

2002 • 72 citations

Tr1 cell–dependent active tolerance blunts the pathogenic effects of determinant spreading

2002 • 67 citations

Natural CD4 CD25+ regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10

2002 • 62 citations

Resistance of Rheumatoid Synovial Dendritic Cells to the Immunosuppressive Effects of IL-10

1999 • 62 citations

Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice

2002 • 61 citations

Phenotypic Characterization of Human CD4+ Regulatory T Cells Obtained from Cutaneous Dinitrochlorobenzene-Induced Delayed Type Hypersensitivity Reactions

2001 • 36 citations

Cytokine production by CD4+ T-cells responding to antigen presentation by melanoma cells

1999 • 12 citations

Regulatory T cells

2001 • 6 citations

Effect of Intranasal Administration of CV-11974, a Type 1 Angiotensin II Receptor Antagonist, on Airway Hyperresponsiveness and Airway Inflammation Induced by Antigen Inhalation in Guinea Pigs

2002 • 6 citations

Tr1 cell–dependent active tolerance blunts the pathogenic effects of determinant spreading

2002 • 5 citations

Airway Responsiveness and Airway Remodeling after Chronic Exposure to Procaterol and Fenoterol in Guinea Pigs in vivo

2002 • 4 citations