Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Free radicals, antioxidants, and human disease: where are we now?

1992 • 2,223 citations

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

1994 • 1,512 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁ gene

1996 • 1,027 citations

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

1993 • 655 citations

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1996 • 634 citations

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2

1999 • 584 citations

Nrf2 is essential for protection against acute pulmonary injury in mice

1999 • 572 citations

Cell and tissue responses to oxidative damage.

1993 • 492 citations

Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

1994 • 434 citations

Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins

1995 • 423 citations

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

1993 • 344 citations

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

1999 • 290 citations

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

1998 • 278 citations

The Maf transcription factors: regulators of differentiation

1997 • 272 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Evaluation of methods for measuring cellular glutathione content using flow cytometry

1994 • 245 citations

Antioxidant response element

1994 • 245 citations

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

1995 • 230 citations

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

1995 • 222 citations

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.

1995 • 210 citations

Identification of a Putative Antioxidant Response Element in the 5′-Flanking Region of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1995 • 187 citations

The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents

1999 • 176 citations

Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.

1993 • 169 citations

The Rat Quinone Reductase Antioxidant Response Element

1995 • 153 citations

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1994 • 152 citations

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression

1994 • 144 citations

Isolation of cDNA encoding the human NF-E2 protein.

1993 • 126 citations

hMAF, a Small Human Transcription Factor That Heterodimerizes Specifically with Nrf1 and Nrf2

1997 • 124 citations

酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング

1993 • 123 citations

Regulation of human γ-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells

1997 • 108 citations

Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif

1997 • 105 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.

1993 • 100 citations

Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1

1996 • 91 citations

Molecular Cloning of a Putative Novel Human bZIP Transcription Factor on Chromosome 17q22

1994 • 86 citations

Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression. Effect of Sulfhydryl Modifying Agents

1994 • 72 citations

Comprehensive Analysis of Proteins Which Interact with the Antioxidant Responsive Element: Correlation of ARE-BP-1 with the Chemoprotective Induction Response

1997 • 63 citations

Human Antioxidant-Response-Element-Mediated Regulation of Type 1 NAD(P)H:quinone Oxidoreductase Gene Expression

1994 • 63 citations

Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization

1995 • 59 citations