Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil.

1991 • 388 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

1991 • 372 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Classification of Acute Leukemia

1977 • 282 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.

1990 • 223 citations

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance.

1992 • 221 citations

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

1987 • 205 citations

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein.

1983 • 201 citations

MDR₁ transcript levels as an indication of resistant disease in acute myelogenous leukaemia

1990 • 184 citations

Estimation of cell survival by flow cytometric quantification of fluorescein diacetate/propidium iodide viable cell number.

1989 • 156 citations

Expression of the multidrug transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance

1990 • 153 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

Isolation and characterization of an anthracycline-resistant human leukemic cell line.

1985 • 137 citations

Multi-Drug Resistance in Cancer

2009 • 129 citations

Expression of the multidrug resistance gene in myeloid leukemias

1990 • 124 citations

Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.

1990 • 116 citations

High risk of early resistant relapse for leukaemic patients with presence of multidrug resistance associated P‐glycoprotein positive cells in complete remission

1991 • 113 citations

Expression of the multidrug transporter, P‐glycoprotein, in chronic myelogenous leukaemia cells in blast crisis

1990 • 92 citations

Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

1989 • 88 citations

Mechanisms and clinical significance of multidrug resistance.

1988 • 86 citations

The significance of CD34 and TdT determinations in patients with untreated de novo acute myeloid leukemia.

1992 • 74 citations

Effect of duration of exposure to verapamil on vincristine activity against multidrug-resistant human leukemic cell lines.

1989 • 59 citations

Selective expression of xenotropic virus in congenic HRS/J (hairless) mice

1977 • 52 citations

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.

1992 • 49 citations

Effects of 1-beta-D-arabinofuranosylcytosine on DNA replication intermediates monitored by pH-step alkaline elution.

1990 • 45 citations

Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.

1990 • 44 citations

Effects of verapamil on the cellular accumulation of daunorubicin in blast cells and on the chemosensitivity of leukaemic blast progenitors in acute myelogenous leukaemia

1989 • 40 citations

Absence of correlation between cytotoxicity and drug transport by P‐glycoprotein in clinical leukemic cells

1991 • 15 citations

Cellular and pharmacologic aspects of drug resistance in acute myeloid leukemia

1991 • 15 citations