Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

A large-conductance mechanosensitive channel in E. coli encoded by mscL alone

1994 • 701 citations

Mechanotransduction in Response to Shear Stress

1999 • 560 citations

Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo

1993 • 468 citations

Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions

1999 • 430 citations

EndoCAM: a novel endothelial cell-cell adhesion molecule.

1990 • 409 citations

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.

1994 • 389 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Vascular Endothelial Cells Respond to Spatial Gradients in Fluid Shear Stress by Enhanced Activation of Transcription Factors

1999 • 351 citations

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition

1998 • 344 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells

1995 • 287 citations

Differential Effect of Shear Stress on Extracellular Signal-regulated Kinase and N-terminal Jun Kinase in Endothelial Cells

1997 • 269 citations

Fluid Flow Rapidly Activates G Proteins in Human Endothelial Cells

1996 • 265 citations

Fluid Shear Stress Activates Ca ²⁺ Influx Into Human Endothelial Cells via P2X4 Purinoceptors

2000 • 250 citations

Temporal Gradient in Shear But Not Steady Shear Stress Induces PDGF-A and MCP-1 Expression in Endothelial Cells

1999 • 221 citations

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2

1999 • 219 citations

The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation

1997 • 215 citations

Molecular Identification of a Eukaryotic, Stretch-Activated Nonselective Cation Channel

1999 • 211 citations

Calcium ions and tyrosine phosphorylation interact coordinately with actin to regulate cytoprotective responses to stretching

1997 • 200 citations

Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.

1994 • 196 citations

Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

1998 • 196 citations

Platelet-endothelial cell adhesion molecule-1 (PECAM-1)–deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane

2001 • 184 citations

Flow-induced changes in Ca2+ signaling of vascular endothelial cells: effect of shear stress and ATP

1991 • 174 citations

Phosphotyrosines 627 and 659 of Gab1 Constitute a Bisphosphoryl Tyrosine-based Activation Motif (BTAM) Conferring Binding and Activation of SHP2

2001 • 160 citations

Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells.

1997 • 155 citations

Endothelial Dysfunction, Hemodynamic Forces, and Atherosclerosis

1999 • 141 citations

Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor

2000 • 135 citations

PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells

1997 • 122 citations

Platelet-Endothelial Cell Adhesion Molecule-1 (CD31), a Scaffolding Molecule for Selected Catenin Family Members Whose Binding Is Mediated by Different Tyrosine and Serine/Threonine Phosphorylation

2000 • 121 citations

PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo

2000 • 116 citations

Role of SH-PTP2, a Protein-Tyrosine Phosphatase with Src Homology 2 Domains, in Insulin-Stimulated Ras Activation

1994 • 108 citations

Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases

1998 • 101 citations

Platelet endothelial cell adhesion molecule‐1 is a major SH‐PTP2 binding protein in vascular endothelial cells

1997 • 101 citations

Platelet Endothelial Cell Adhesion Molecule-1 Is Phosphorylatable by c-Src, Binds Src-Src homology 2 Domain, and Exhibits Immunoreceptor Tyrosine-based Activation Motif-like Properties

1997 • 99 citations

Fluid Shear Stress Induction of the Tissue Factor Promoter In Vitro and In Vivo Is Mediated by Egr-1

1999 • 87 citations

Lateral Zone of Cell-Cell Adhesion as the Major Fluid Shear Stress–Related Signal Transduction Site

2000 • 76 citations

Is PECAM-1 a Mechanoresponsive Molecule?

2001 • 60 citations

Macromolecular Composition of Stress Fiber–Plasma Membrane Attachment Sites in Endothelial Cells In Situ

1996 • 58 citations

Fluid Flow and Osmotic Stress Induce Tyrosine Phosphorylation of an Endothelial Cell 128-kDa Surface Glycoprotein

1995 • 49 citations

PECAM-1 (CD31) regulates a hydrogen peroxide–activated nonselective cation channel in endothelial cells

2002 • 49 citations

Inactivation of Mitogen-Activated Protein Kinases by a Mammalian Tyrosine-Specific Phosphatase, PTPBR7

1999 • 26 citations