Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility

Geometric Control of Cell Life and Death

1997 • 4,614 citations

Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering

1994 • 4,448 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Cell Movement Is Guided by the Rigidity of the Substrate

2000 • 3,179 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Role of cell shape in growth control

1978 • 2,434 citations

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

2004 • 2,220 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Self-Organization in Nonequilibrium Systems: From Dissipative Structures to Order through Fluctuations

1977 • 2,087 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Podosomes: adhesion hot-spots of invasive cells

2003 • 607 citations

Foot and mouth: podosomes, invadopodia and circular dorsal ruffles

2004 • 587 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Cell shape provides global control of focal adhesion assembly

2003 • 535 citations

Cellular Control of Actin Nucleation

2002 • 507 citations

Molecular diversity of cell-matrix adhesions

1999 • 444 citations

Podosomes Display Actin Turnover and Dynamic Self-Organization in Osteoclasts Expressing Actin-Green Fluorescent Protein

2003 • 428 citations

Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes

1985 • 426 citations

Focal adhesions: Structure and dynamics

2000 • 380 citations

[39] Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells

1998 • 371 citations

Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target

2002 • 358 citations

Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells

1989 • 334 citations

Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus.

1980 • 296 citations

Regulation of substrate adhesion dynamics during cell motility

2002 • 268 citations

Gelsolin Deficiency Blocks Podosome Assembly and Produces Increased Bone Mass and Strength

2000 • 261 citations

Dynamic Actin Patterns and Arp2/3 Assembly at the Substrate-Attached Surface of Motile Cells

2004 • 259 citations

Apatite-mediated Actin Dynamics in Resorbing Osteoclasts

2004 • 257 citations

In vitro tubulogenesis of endothelial cells by relaxation of the coupling extracellular matrix-cytoskeleton

2001 • 252 citations

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

2002 • 226 citations

Podosomes at a glance

2005 • 210 citations

Actin Can Reorganize into Podosomes in Aortic Endothelial Cells, a Process Controlled by Cdc42 and RhoA

2003 • 188 citations

Cell Locomotion and Focal Adhesions Are Regulated by the Mechanical Properties of the Substrate

1998 • 183 citations

Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages

2000 • 179 citations

Podosomes in osteoclast-like cells

2001 • 168 citations

The world according to Arp: regulation of actin nucleation by the Arp2/3 complex

1999 • 166 citations

A band of F-actin containing podosomes is involved in bone resorption by osteoclasts

1990 • 155 citations

Macrophage podosomes assemble at the leading lamella by growth and fragmentation

2003 • 154 citations

Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function

2004 • 147 citations

2,3-Butanedione monoxime (BDM) as a myosin inhibitor.

2002 • 142 citations

Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains

2003 • 139 citations

Molecular responses of human dermal fibroblasts to dual cues: Contact guidance and mechanical load

2000 • 135 citations

Subconfluent endothelial cells form podosomes downstream of cytokine and RhoGTPase signaling

2005 • 123 citations

Eukaryotic Cell Locomotion Depends on the Propagation of Self-Organized Reaction–Diffusion Waves and Oscillations of Actin Filament Assembly

2002 • 110 citations

Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains

2003 • 108 citations

A dynamic podosome-like structure of epithelial cells

2004 • 104 citations

Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium

2005 • 102 citations

Wiskott–Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells

2004 • 96 citations

Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in rsv-transformed bhk cells

1989 • 87 citations

Podosome-mediated matrix resorption and cell motility in vascular smooth muscle cells

2005 • 86 citations

Mechanical properties, proteolytic degradability and biological modifications affect angiogenic process extension into native and modified fibrin matrices in vitro

2004 • 85 citations

Morphological and biochemical analyses of contractile proteins (actin, myosin, caldesmon and tropomyosin) in normal and transformed cells

1993 • 83 citations

Actin-Related Protein 2/3 Complex Is Required for Actin Ring Formation

2004 • 82 citations

Fimbrin in podosomes of monocyte-derived osteoclasts

1997 • 71 citations

Mechanical signalling and angiogenesis. The integration of cell–extracellular matrix couplings

2000 • 63 citations

Cell movement and shape are non-random and determined by intracellular, oscillatory rotating waves in Dictyostelium amoebae

1994 • 37 citations

Characterization of cell deformation and migration using a parametric estimation of image motion

1999 • 34 citations

A mathematical model for the dynamics of large membrane deformations of isolated fibroblasts

2003 • 33 citations

The use of optical flow to characterize muscle contraction

2001 • 25 citations

Patterns of spontaneous motility in videomicrographs of human epidermal keratinocytes (HEK)

1995 • 24 citations

Quantitation of cell-matrix adhesion using confocal image analysis of focal contact associated proteins and interference reflection microscopy

1997 • 21 citations

Periodic activity of the cortical cytoskeleton of the lymphoblast: modelling by a reaction-diffusion system

1997 • 9 citations