How do microtubules guide migrating cells?

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Beyond self-assembly: From microtubules to morphogenesis

1986 • 1,334 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

The lamellipodium: where motility begins

2002 • 913 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

2002 • 741 citations

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

2001 • 724 citations

Mechanical behavior in living cells consistent with the tensegrity model

2001 • 705 citations

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

2002 • 633 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

mDia mediates Rho-regulated formation and orientation of stable microtubules

2001 • 566 citations

Assembly and mechanosensory function of focal contacts

2001 • 548 citations

Self-polarization and directional motility of cytoplasm

1999 • 493 citations

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

1999 • 491 citations

Functional cooperation between the microtubule and actin cytoskeletons

2000 • 473 citations

Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study

1992 • 456 citations

Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation

1999 • 452 citations

Cell motility: can Rho GTPases and microtubules point the way?

2001 • 447 citations

Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones

2002 • 436 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

Marching at the front and dragging behind

2001 • 358 citations

Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1

2000 • 350 citations

Focal Adhesion Motility Revealed in Stationary Fibroblasts

1999 • 345 citations

Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

1998 • 323 citations

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

1989 • 303 citations

Effect of colcemid on the locomotory behaviour of fibroblasts

1970 • 296 citations

Cloning and Characterization of GEF-H1, a Microtubule-associated Guanine Nucleotide Exchange Factor for Rac and Rho GTPases

1998 • 296 citations

Mechanism of retraction of the trailing edge during fibroblast movement.

1981 • 290 citations

Flexural rigidity of microtubules measured with the use of optical tweezers

1996 • 288 citations

Regulation of substrate adhesion dynamics during cell motility

2002 • 268 citations

Flexible substrata for the detection of cellular traction forces

2002 • 262 citations

Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells

1999 • 258 citations

A mechanical function of myosin II in cell motility

1995 • 254 citations

Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules

1984 • 244 citations

Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain.

1995 • 229 citations

Actin-dependent Lamellipodia Formation and Microtubule-dependent Tail Retraction Control-directed Cell Migration

2000 • 226 citations

Microtubule Disruption Induces the Formation of Actin Stress Fibers and Focal Adhesions in Cultured Cells: Possible Involvement of the Rho Signal Cascade.

1996 • 214 citations

Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells

2002 • 211 citations

The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate–Cytoskeletal Coupling

1998 • 209 citations

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions

1999 • 197 citations

Microtubule Depolymerization Induces Stress Fibers, Focal Adhesions, and DNA Synthesis via the GTP-Binding Protein Rho

1998 • 197 citations

Characterization of p190RhoGEF, A RhoA-specific Guanine Nucleotide Exchange Factor That Interacts with Microtubules

2001 • 172 citations

Separation of Propulsive and Adhesive Traction Stresses in Locomoting Keratocytes

1999 • 164 citations

Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain.

1993 • 160 citations

Buckling Microtubules in Vesicles

1996 • 157 citations

Membrane traffic during cell locomotion

1998 • 149 citations

Tensile stress stimulates microtubule outgrowth in living cells

2002 • 127 citations

Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1

2002 • 120 citations

Cell Adhesion and Motility

2006 • 117 citations

Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration.

1994 • 116 citations

Cytochalasin separates microtubule disassembly from loss of asymmetric morphology.

1981 • 105 citations

Pseudopodial activity at the active edge of migrating fibroblast is decreased after drug‐induced microtubule depolymerization

1991 • 104 citations

Dynamics of fibroblast spreading

1995 • 102 citations

Microtubules suppress actomyosin-based cortical flow in Xenopus oocytes

1997 • 95 citations

Effects of colchicine, vinblastine and nocodazole on polarity, motility, chemotaxis and cAMP levels of human polymorphonuclear leukocytes

1984 • 83 citations

Induction of cortical oscillations in spreading cells by depolymerization of microtubules

2001 • 82 citations

Microtubules don and doff their caps: dynamic attachments at plus and minus ends

2001 • 80 citations

Contact dynamics during keratocyte motility

2000 • 77 citations

Balanced mechanical forces and microtubule contribution to fibroblast contraction

1996 • 77 citations

The cortical microfilament system of lymphoblasts displays a periodic oscillatory activity in the absence of microtubules: implications for cell polarity.

1989 • 77 citations

Microtubule Depolymerization Normalizes In Vivo Myocardial Contractile Function in Dogs With Pressure-Overload Left Ventricular Hypertrophy

2000 • 74 citations

Enforced polarisation and locomotion of fibroblasts lacking microtubules

2000 • 72 citations

Microtubule involvement in regulating cell contractility and adhesion-dependent signalling: a possible mechanism for polarization of cell motility.

1999 • 59 citations

Effects of microtubule disruption on force, velocity, stiffness and [Ca²⁺]_iin porcine coronary arteries

2000 • 54 citations

Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.

1992 • 50 citations

Role of microtubules in random cell migration: Stabilization of cell polarity

1994 • 44 citations

Rapid, microtubule-dependent fluctuations of the cell margin

1997 • 43 citations

Maturation of Cell-Substratum Focal Adhesions Induced by Depolymerization of Microtubules is Mediated by Increased Cortical Tension

1998 • 41 citations

Phenotype modulation in non-adherent and adherent sublines of Walker carcinosarcoma cells: the role of cell-substratum contacts and microtubules in controlling cell shape, locomotion and cytoskeletal structure

2002 • 29 citations

Influence of microtubules on vascular smooth muscle contraction.

2000 • 28 citations

Microtubule-dependent effect of phorbol ester on the contractility of cytoskeleton of cultured fibroblasts.

1988 • 24 citations