Cellular mechanotransduction: putting all the pieces together again

Geometric Control of Cell Life and Death

1997 • 4,614 citations

Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

2004 • 4,004 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

2003 • 1,966 citations

Cells lying on a bed of microneedles: An approach to isolate mechanical force

2003 • 1,919 citations

Single myosin molecule mechanics: piconewton forces and nanometre steps

1994 • 1,894 citations

Myotubes differentiate optimally on substrates with tissue-like stiffness

2004 • 1,629 citations

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

1997 • 1,572 citations

TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

1997 • 1,550 citations

Engineering Cell Shape and Function

1994 • 1,447 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Tensegrity I. Cell structure and hierarchical systems biology

2003 • 1,202 citations

A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage

1991 • 1,073 citations

Muscles, Reflexes, and Locomotion

1984 • 1,019 citations

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction

2004 • 888 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

The relationship between force and focal complex development

2002 • 876 citations

Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction

2004 • 863 citations

Emergent patterns of growth controlled by multicellular form and mechanics

2005 • 822 citations

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

2004 • 712 citations

Mechanical behavior in living cells consistent with the tensegrity model

2001 • 705 citations

Visualizing the mechanical activation of Src

2005 • 658 citations

Viscoelastic Retraction of Single Living Stress Fibers and Its Impact on Cell Shape, Cytoskeletal Organization, and Extracellular Matrix Mechanics

2006 • 648 citations

TRPC1 forms the stretch-activated cation channel in vertebrate cells

2005 • 640 citations

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

2002 • 633 citations

Transcription Against an Applied Force

1995 • 583 citations

Cell shape provides global control of focal adhesion assembly

2003 • 535 citations

Integrins Regulate Rac Targeting by Internalization of Membrane Domains

2004 • 533 citations

Reverse engineering of the giant muscle protein titin

2002 • 505 citations

Mechanical Induction of Twist in the Drosophila Foregut/Stomodeal Primordium

2003 • 498 citations

Cell type-specific response to growth on soft materials

2005 • 491 citations

How we are shaped: The biomechanics of gastrulation

2003 • 484 citations

Control of Cyclin D1, p27^Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension

1998 • 476 citations

The mechanical stability of ubiquitin is linkage dependent

2003 • 475 citations

Cadherin 23 is a component of the tip link in hair-cell stereocilia

2004 • 470 citations

Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

1997 • 470 citations

Impaired mechanical stability, migration and contractile capacity in vimentin deficient fibroblasts

1998 • 469 citations

Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces

2002 • 458 citations

Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels

2006 • 444 citations

Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates

1999 • 436 citations

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

2003 • 435 citations

Auditory sensitivity provided by self-tuned critical oscillations of hair cells

2000 • 401 citations

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

2001 • 398 citations

The Mechanical Hierarchies of Fibronectin Observed with Single-molecule AFM

2002 • 396 citations

Compression-induced changes in the shape and volume of the chondrocyte nucleus

1995 • 394 citations

Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions

1998 • 368 citations

Tensegrity: Construction of Rigid DNA Triangles with Flexible Four-Arm DNA Junctions

2004 • 355 citations

Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension

2002 • 355 citations

The gating mechanism of the large mechanosensitive channel MscL

2001 • 350 citations

Mechanotransduction through growth-factor shedding into the extracellular space

2004 • 343 citations

Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro

2004 • 342 citations

Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression

2002 • 340 citations

Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers

2003 • 339 citations

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

2004 • 330 citations

Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces.

1994 • 322 citations

Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond

2004 • 320 citations

Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata.

1984 • 314 citations

Unfolding proteins by external forces and temperature: The importance of topology and energetics

2000 • 296 citations

Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces

2005 • 291 citations

Lamins: building blocks or regulators of gene expression?

2002 • 288 citations

Tension and compression in the cytoskeleton of PC-12 neurites. II: Quantitative measurements.

1988 • 288 citations

Calcium imaging of single stereocilia in hair cells: Localization of transduction channels at both ends of tip links

1995 • 265 citations

Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

2001 • 259 citations

Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells

2003 • 257 citations

Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension

2004 • 254 citations

Geometric Determinants of Directional Cell Motility Revealed Using Microcontact Printing

2003 • 249 citations

Electromechanical and physicochemical properties of connective tissue.

1983 • 247 citations

Mechanical control of cyclic AMP signalling and gene transcription through integrins

2000 • 245 citations

Movement and self-control in protein assemblies. Quasi-equivalence revisited

1980 • 244 citations

Shear stress modulates endothelial cell morphology and F‐actin organization through the regulation of focal adhesion‐associated proteins

1995 • 244 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Effects of cell tension on the small GTPase Rac

2002 • 237 citations

Mechanical Properties of a Reversible, DNA-Crosslinked Polyacrylamide Hydrogel

2004 • 235 citations

Mechanosensitive Channels: Multiplicity of Families and Gating Paradigms

2004 • 231 citations

Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence

2000 • 226 citations

Tension and compression in the cytoskeleton of PC 12 neurites.

1985 • 224 citations

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

2001 • 222 citations

The riddle of morphogenesis: A question of solution chemistry or molecular cell engineering?

1993 • 219 citations

Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells

2005 • 216 citations

Hypothesis: A helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors

2004 • 212 citations

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton.

1996 • 212 citations

Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress

2004 • 208 citations

Contraction-Induced Cell Wounding and Release of Fibroblast Growth Factor in Heart

1995 • 206 citations

Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity

2003 • 202 citations

Role of basal lamina in neoplastic disorganization of tissue architecture.

1981 • 202 citations

RPTP-α acts as a transducer of mechanical force on αv/β3-integrin–cytoskeleton linkages

2003 • 199 citations

Microtubule Depolymerization Induces Stress Fibers, Focal Adhesions, and DNA Synthesis via the GTP-Binding Protein Rho

1998 • 197 citations

Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae

1998 • 191 citations

Extrusion and Death of DPP/BMP-Compromised Epithelial Cells in the Developing Drosophila Wing

2005 • 187 citations

Vascular Endothelial-Cadherin Regulates Cytoskeletal Tension, Cell Spreading, and Focal Adhesions by Stimulating RhoA

2004 • 176 citations

Mathematics and Tensegrity

1998 • 169 citations

Mechanoelectrical transduction by hair cells

1992 • 168 citations

Gastrointestinal Cell Plasma Membrane Wounding and Resealing In Vivo

1989 • 168 citations

Cytoskeletal Plasticity in Cells Expressing Neuronal Microtubule-Associated Proteins

1996 • 162 citations

Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers

2004 • 158 citations

Cadherins Mediate Intercellular Mechanical Signaling in Fibroblasts by Activation of Stretch-sensitive Calcium-permeable Channels

2001 • 155 citations

Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells

1997 • 152 citations

Connexins are mechanosensitive

2004 • 152 citations

Conversion of Mechanical Force into Biochemical Signaling

2004 • 148 citations

Adaptation of muscle size and myofascial force transmission: a review and some new experimental results

2005 • 147 citations

Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction

2004 • 147 citations

Fluid Shear Stress Induces ?-Catenin Signaling in Osteoblasts

2004 • 147 citations

Tissue-Engineered Skeletal Muscle Organoids for Reversible Gene Therapy

1996 • 146 citations

Mapping Mechanical Strain of an Endogenous Cytoskeletal Network in Living Endothelial Cells

2003 • 144 citations

Bending the Primary Cilium Opens Ca2+-sensitive Intermediate-Conductance K+ Channels in MDCK Cells

2003 • 143 citations

Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization

2004 • 138 citations

Microfilament or microtubule assembly or disassembly against a force.

1981 • 137 citations

Mechanical anisotropy of adherent cells probed by a three-dimensional magnetic twisting device

2004 • 135 citations

Prestress mediates force propagation into the nucleus

2005 • 134 citations

Mechanical properties of individual focal adhesions probed with a magnetic microneedle

2003 • 133 citations

Forced unfolding modulated by disulfide bonds in the Ig domains of a cell adhesion molecule

2001 • 132 citations

Three-dimensional architecture of elastin and collagen fiber networks in the human and rat lung

2004 • 129 citations

Integrins and Modulation of Transmitter Release from Motor Nerve Terminals by Stretch

1995 • 128 citations

Actin stress fibres and cell–cell adhesion molecules in tendons: organisation in vivo and response to mechanical loading of tendon cells in vitro

2002 • 126 citations

A Computational Tensegrity Model Predicts Dynamic Rheological Behaviors in Living Cells

2004 • 119 citations

Global cytoskeletal control of mechanotransduction in kidney epithelial cells

2004 • 115 citations

Mechanobiological predictions of growth front morphology in developmental hip dysplasia

2003 • 115 citations

Long-distance propagation of forces in a cell

2005 • 114 citations

Cell spreading controls endoplasmic and nuclear calcium: A physical gene regulation pathway from the cell surface to the nucleus

2003 • 113 citations

Rho-ROCK-LIMK-Cofilin Pathway Regulates Shear Stress Activation of Sterol Regulatory Element Binding Proteins

2003 • 112 citations

Focal Adhesion Protein Zyxin Is a Mechanosensitive Modulator of Gene Expression in Vascular Smooth Muscle Cells

2004 • 112 citations

Micromechanical foundations of pulmonary elasticity

1990 • 111 citations

Converging Populations of F-Actin Promote Breakage of Associated Microtubules to Spatially Regulate Microtubule Turnover in Migrating Cells

2002 • 111 citations

An actin barrier to resealing

2001 • 105 citations

Early Adaptive Responses of the Vascular Wall during Venous Arterialization in Mice

2004 • 104 citations

Adhesion-contractile balance in myocyte differentiation

2004 • 104 citations

Gap junctions and fluid flow response in MC3T3-E1 cells

2001 • 102 citations

Equibiaxial strain and strain rate stimulate early activation of G proteins in cardiac fibroblasts

1998 • 98 citations

Mechanically gated channel activity in cytoskeleton‐deficient plasma membrane blebs and vesicles from Xenopus oocytes

2000 • 95 citations

Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish

2004 • 94 citations

Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells

2000 • 92 citations

Control of microtubule assembly by extracellular matrix and externally applied strain

2001 • 91 citations

Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response.

1996 • 90 citations

Molten Globule Structures in Milk Proteins: Implications for Potential New Structure-Function Relationships

2002 • 87 citations

A Quantitative Model of Cellular Elasticity Based on Tensegrity

1999 • 87 citations

External mechanical strain regulates membrane targeting of Rho GTPases by controlling microtubule assembly

2003 • 85 citations

Compressive behavior of articular cartilage is not completely explained by proteoglycan osmotic pressure

1997 • 84 citations

FORCE EFFECTS ON BIOCHEMICAL KINETICS

1997 • 82 citations

Glycosaminoglycan network geometry may contribute to anisotropic hydraulic permeability in cartilage under compression

2001 • 81 citations

Cytoskeletal mechanics in confluent epithelial cells probed through integrins and E-cadherins

1997 • 81 citations

Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase treatment

2003 • 80 citations

A thermodynamic model for force integration and microtubule assembly during axonal elongation

1988 • 80 citations

Depletion of plasma membrane cholesterol dampens hydrostatic pressure and shear stress-induced mechanotransduction pathways in osteoblast cultures

2004 • 79 citations

Traction fibre: Toward a “tensegral” model of the spindle

1997 • 79 citations

Embryonic wound healing by apical contraction and ingression in Xenopus laevis

2002 • 77 citations

Beta1-integrins co-localize with Na, K-ATPase, epithelial sodium channels (ENaC) and voltage activated calcium channels (VACC) in mechanoreceptor complexes of mouse limb-bud chondrocytes.

2003 • 74 citations

Neutral sphingomyelinase inhibitor scyphostatin prevents and ceramide mimics mechanotransduction in vascular endothelium

2004 • 67 citations

The disruption of myofibre structures in rat skeletal muscle after forced lengthening contractions

1998 • 67 citations

Muscular dystrophies, the cytoskeleton and cell adhesion

2002 • 64 citations

Corneal Fibroblasts Respond Rapidly to Changes in Local Mechanical Stress

2004 • 64 citations

3-D Nanomechanics of an Erythrocyte Junctional Complex in Equibiaxial and Anisotropic Deformations

2005 • 61 citations

The origin of cellular life

2000 • 59 citations

Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover.

1994 • 54 citations

Toward replicatable, multifunctional, nanoscaffolded machines. A chemical manifesto

2003 • 50 citations

Cell spreading controls balance of prestress by microtubules and extracellular matrix

2004 • 49 citations

The Membrane-based Mechanism of Cell Motility in Cochlear Outer Hair Cells

1998 • 48 citations

ERK activation by mechanical strain is regulated by the small G proteins rac‐1 and rhoA

2004 • 44 citations

Possible mechanisms of indirect gravity sensing by cells.

1991 • 44 citations

A Microstructural Model of Elastostatic Properties of Articular Cartilage in Confined Compression

2000 • 42 citations

L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events

2004 • 38 citations

Is tensegrity a unifying concept of protein folds?

2002 • 36 citations

Nonequilibrium statistical mechanical models for cytoskeletal assembly: Towards understanding tensegrity in cells

2005 • 35 citations

Modeling Virus Self-Assembly Pathways: Avoiding Dynamics Using Geometric Constraint Decomposition

2006 • 32 citations

Toward a Generalised Tensegrity Model Describing the Mechanical Behaviour of the Cytoskeleton Structure

2003 • 24 citations

Caveolin‐1 redistribution in human endothelial cells induced by laminar flow and cytokine

2003 • 21 citations

Possible Mechanisms of Indirect Gravity Sensing by Cells

2007 • 16 citations

Cytoskeletal integration in a highly ordered sensory epithelium in the organ of Corti: reponse to loss of cell partners in the Bronx waltzer mouse.

1999 • 16 citations