Effect of protein kinase inhibitor H‐7 on the contractility, integrity, and membrane anchorage of the microfilament system

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Mechanosensitive ion channels

1990 • 721 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Chemotaxis in Eukaryotic Cells: A Focus on Leukocytes and Dictyostelium

1988 • 623 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Induction of human vascular endothelial stress fibres by fluid shear stress

1984 • 538 citations

Potent selective inhibitors of protein kinase C

1989 • 482 citations

Cadherins

1992 • 437 citations

A new protein of adhesion plaques and ruffling membranes.

1983 • 395 citations

CONTROL OF NONMUSCLE MYOSINS BY PHOSPHORYLATION

1992 • 338 citations

Actin Filament Stress Fibers in Vascular Endothelial Cells in Vivo

1983 • 334 citations

Alignment of fibroblasts on grooved surfaces described by a simple geometric transformation

1986 • 333 citations

Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro

1982 • 316 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

A transparent access chamber for the rat dorsal skin fold

1979 • 287 citations

Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells

1992 • 280 citations

Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.

1988 • 279 citations

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape

1992 • 274 citations

Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands

1993 • 260 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.

1984 • 249 citations

A 135-kd membrane protein of intercellular adherens junctions.

1984 • 235 citations

Effects of mechanical tension on protrusive activity and microfilament and intermediate filament organization in an epidermal epithelium moving in culture.

1986 • 230 citations

Changes in membrane-microfilament interaction in intercellular adherens junctions upon removal of extracellular Ca2+ ions.

1986 • 225 citations

Are stress fibres contractile?

1981 • 224 citations

Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells.

1985 • 218 citations

Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.

1989 • 210 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth

1977 • 194 citations

Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells.

1985 • 187 citations

Tumor promoter-induced changes in the permeability of epithelial cell tight junctions

1981 • 185 citations

Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells.

1991 • 164 citations

A-CAM: a 135-kD receptor of intercellular adherens junctions. II. Antibody-mediated modulation of junction formation.

1986 • 160 citations

Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor

1988 • 156 citations

Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor

1984 • 155 citations

Quantitation of actin polymerization in two human fibroblast sub-types responding to mechanical stretching

1991 • 149 citations

Phosphorylation of smooth muscle myosin light chain kinase by protein kinase C. Comparative study of the phosphorylated sites.

1985 • 145 citations

Astrocyte process growth induction by actin breakdown

1992 • 141 citations

Epidermal growth factor induces redistribution of actin and α-actinin in human epidermal carcinoma cells

1981 • 139 citations

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors.

1986 • 136 citations

KT5926, a potent and selective inhibitor of myosin light chain kinase.

1990 • 130 citations

Cytoskeleton

1988 • 129 citations

Phosphorylation of smooth muscle myosin light chain kinase by Ca2+-activated, phospholipid-dependent protein kinase.

1985 • 128 citations

Tension as a regulator and integrator of axonal growth

1990 • 94 citations

Contractile activity and cell-cell contact regulate myofibrillar organization in cultured cardiac myocytes.

1993 • 88 citations

Modulation of cellular morphology and locomotory activity by antibodies against myosin.

1988 • 88 citations

A thermodynamic model for force integration and microtubule assembly during axonal elongation

1988 • 80 citations

Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7

1994 • 79 citations

Correlation between tension force generation, fibrillogenesis and ultrastructure of cytoplasmic actomyosin during isometric and isotonic contractions of protoplasmic strands

1975 • 72 citations

Changes in fibroblast contractility, morphology, and adhesion in response to a phorbol ester tumor promoter

1988 • 70 citations

Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts.

1991 • 69 citations

Cytoplasmic Control of Cell Adhesion

1992 • 62 citations

Hypertrophy of isolated adult feline heart cells following beta-adrenergic-induced beating

1991 • 59 citations

The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source

1992 • 57 citations

Cytoskeletal reorganizations responsible for the phorbol ester-induced formation of cytoplasmic processes: possible involvement of intermediate filaments.

1990 • 57 citations

Protein kinase C inhibitor H‐7 alters the actin cytoskeleton of cultured cells

1989 • 54 citations

Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites

1994 • 51 citations

Parathyroid hormone promotes the disassembly of cytoskeletal actin and myosin in cultured osteoblastic cells: Mediation by cyclic AMP

1991 • 50 citations

Myosin light chain kinase occurs in bullfrog sympathetic neurons and may modulate voltage-dependent potassium currents

1993 • 48 citations

Special type of morphological reorganization induced by phorbol ester: reversible partition of cell into motile and stable domains.

1987 • 37 citations

Microinjection of catalytic subunit of cyclic AMP‐dependent protein kinases triggers acute morphological changes in thyroid epithelial cells

1988 • 37 citations

Cell Behaviour: Adhesion and Motility

1993 • 37 citations

Actin-associated proteins in motility and chemotaxis of Dictyostelium cells.

1993 • 37 citations

Supercontracted state of vertebrate smooth muscle cell fragments reveals myofilament lengths.

1990 • 34 citations

Shapes of cells spreading on fibronectin: measurement of the stellation of BHK21 cells induced by raising cyclic AMP, and of its reversal by serum and lysophosphatidic acid

1993 • 27 citations

The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility.

1993 • 25 citations

Microtubule-dependent effect of phorbol ester on the contractility of cytoskeleton of cultured fibroblasts.

1988 • 24 citations

A quantitative analysis of alterations in the shape of cultured fibroblasts induced by tumour-promoting phorbol ester

1989 • 21 citations