Force-induced unfolding of the focal adhesion targeting domain and the influence of paxillin binding.

VMD: Visual molecular dynamics

1996 • 54,630 citations

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Dynamic strength of molecular adhesion bonds

1997 • 2,444 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy

1999 • 1,695 citations

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

1997 • 1,572 citations

Signaling through focal adhesion kinase

1999 • 1,169 citations

Molecular Basis of Mechanotransduction in Living Cells

2001 • 1,102 citations

Conformational change of proteins arising from normal mode calculations

2001 • 874 citations

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

2000 • 661 citations

A Comprehensive Analytical Treatment of Continuum Electrostatics

1996 • 552 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

Exploring the Neighborhood

2002 • 398 citations

Steered molecular dynamics investigations of protein function

2001 • 352 citations

Focal adhesion kinase in integrin-mediated signaling

1999 • 345 citations

Mechanotransduction through growth-factor shedding into the extracellular space

2004 • 343 citations

Normal modes for specific motions of macromolecules: application to the hinge-bending mode of lysozyme.

1985 • 340 citations

Force transduction by Triton cytoskeletons

2002 • 289 citations

Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence

2000 • 226 citations

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

2002 • 212 citations

Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity

2001 • 211 citations

Hinge‐bending motion in citrate synthase arising from normal mode calculations

1995 • 202 citations

Components of cell-matrix adhesions

2001 • 200 citations

Temporal Gradients in Shear, but Not Spatial Gradients, Stimulate Endothelial Cell Proliferation

2001 • 181 citations

Microtubule bending and breaking in living fibroblast cells

1999 • 149 citations

Mapping Mechanical Strain of an Endogenous Cytoskeletal Network in Living Endothelial Cells

2003 • 144 citations

Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation

1999 • 116 citations

Paxillin LD motifs may define a new family of protein recognition domains

1998 • 112 citations

Structural Insight into the Mechanisms of Targeting and Signaling of Focal Adhesion Kinase

2002 • 99 citations

Focal adhesion kinase

1997 • 99 citations

Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells.

2001 • 94 citations

The paxillin LD motifs

2001 • 90 citations

Targeting Membrane-localized Focal Adhesion Kinase to Focal Adhesions

2003 • 89 citations

Force-induced focal adhesion translocation: effects of force amplitude and frequency

2004 • 80 citations

Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase

2000 • 63 citations