Mechanisms of platelet-derived growth factor-induced chemotaxis

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

FAK integrates growth-factor and integrin signals to promote cell migration

2000 • 1,215 citations

Signaling through focal adhesion kinase

1999 • 1,169 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

Signal transduction via platelet-derived growth factor receptors

1998 • 735 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

From receptors to stress-activated MAP kinases

1999 • 525 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Signaling to Rho GTPases

1999 • 411 citations

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

1999 • 401 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

1997 • 350 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains

1995 • 276 citations

A glioma-derived PDGF a chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets

1988 • 264 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

1992 • 259 citations

rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.

1993 • 236 citations

Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.

1992 • 231 citations

Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.

1994 • 194 citations

Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

1997 • 173 citations

Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration

1999 • 171 citations

Identification of a Putative Syp Substrate, the PDGFβ Receptor

1995 • 158 citations

Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation

1997 • 156 citations

Role of P120 Ras-Gap in Directed Cell Movement

2000 • 148 citations

Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways

2000 • 145 citations

The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C

1997 • 133 citations

PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF

1997 • 123 citations

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

1996 • 123 citations

Involvement of Phosphatidylinositide 3′-Kinase and Rac in Platelet-Derived Growth Factor-Induced Actin Reorganization and Chemotaxis

1997 • 120 citations

The chemotactic response to PDGF-BB: evidence of a role for Ras.

1995 • 116 citations

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.

1994 • 113 citations

Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts

1997 • 112 citations

Structure and function of the low Mr phosphotyrosine protein phosphatases

1997 • 107 citations

PDGF receptor as a specific in vivo target for low M_r phosphotyrosine protein phosphatase

1995 • 106 citations

Grb10, a Positive, Stimulatory Signaling Adapter in Platelet-Derived Growth Factor BB-, Insulin-Like Growth Factor I-, and Insulin-Mediated Mitogenesis

1999 • 105 citations

The Low M r Protein-tyrosine Phosphatase Is Involved in Rho-mediated Cytoskeleton Rearrangement after Integrin and Platelet-derived Growth Factor Stimulation

2000 • 95 citations

The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors

1995 • 93 citations

Mutations of the Platelet-Derived Growth Factor Receptor That Cause a Loss of Ligand-Induced Conformational Change, Subtle Changes in Kinase Activity, and Impaired Ability To Stimulate DNA Synthesis

1989 • 89 citations

Relative Platelet-derived Growth Factor Receptor Subunit Expression Determines Cell Migration to Different Dimeric Forms of PDGF

1990 • 87 citations

HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase

1995 • 85 citations

Grb7 is a Downstream Signaling Component of Platelet-derived Growth Factor α- and β-Receptors

1996 • 80 citations

SHP-2 binds to Tyr763 and Tyr1009 in the PDGF β-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis

1999 • 80 citations

Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

1989 • 78 citations

Mitogen-Activated Protein Kinase Activation Mediates PDGF- Directed Migration of RPE Cells

1998 • 69 citations

Heparan Sulfate Proteoglycans Mediate a Potent Inhibitory Signal for Migration of Vascular Smooth Muscle Cells

1998 • 68 citations

Phosphatidylinositol 3-Kinase-independent Signal Transduction Pathway for Platelet-derived Growth Factor-induced Chemotaxis

1996 • 65 citations

Tyrosine Phosphatase SHP-2 Is Involved in Regulation of Platelet-derived Growth Factor-induced Migration

1999 • 64 citations

Multiple Roles for Src in a PDGF-Stimulated Cell

1999 • 59 citations

Low Molecular Weight Protein-tyrosine Phosphatase Tyrosine Phosphorylation by c-Src during Platelet-derived Growth Factor-induced Mitogenesis Correlates with Its Subcellular Targeting

1998 • 54 citations

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis.

1989 • 54 citations

The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding

1997 • 53 citations

The GRB family of SH2 domain proteins

1994 • 48 citations

No requirement for Src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen

2000 • 45 citations

Overactivation of Phospholipase C-γ1 Renders Platelet-derived Growth Factor β-Receptor-expressing Cells Independent of the Phosphatidylinositol 3-Kinase Pathway for Chemotaxis

1999 • 44 citations

IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system

2000 • 44 citations

Localization and Down-Regulating Role of the Protein Tyrosine Phosphatase PTP2C in Membrane Ruffles of PDGF-Stimulated Cells

1996 • 25 citations