rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

A novel ras-related gene family

1985 • 487 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.

1991 • 279 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.

1990 • 204 citations

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

1991 • 195 citations

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

1989 • 161 citations

Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K ⁺ Channel Currents

1992 • 154 citations

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1993 • 137 citations

Signal transduction through small GTPases—A tale of two GAPs

1992 • 137 citations

Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 • 114 citations

Suppression of src transformation by overexpression of full-length GTPase-activating protein (GAP) or of the GAP C terminus.

1991 • 101 citations

Inhibition of v-src-induced transformation by a GTPase-activating protein.

1991 • 94 citations

A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.

1992 • 78 citations

Plasma Membrane-Targeted ras GTPase-Activating Protein Is a Potent Suppressor of p21^ras Function

1993 • 67 citations

Protein-Tyrosine Kinases Regulate the Phosphorylation, Protein Interactions, Subcellular Distribution, and Activity of p21^rasGTPase-Activating Protein

1991 • 50 citations

Tyrosine phosphorylation of GAP and GAP-associated proteins in lymphoid and fibroblast cells expressing lck.

1991 • 38 citations

Growth-Regulated Expression of rhoG, a New Member of the ras Homolog Gene Family

1992 • 29 citations

A Limited Set of SH2 Domains Binds BCR through a High- Affinity Phosphotyrosine-Independent Interaction

1992 • 28 citations

Inhibition of v-src-Induced Transformation by a GTPase-Activating Protein

1991 • 20 citations