Multiple Roles for Src in a PDGF-Stimulated Cell

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

1994 • 407 citations

Cell Transformation by the Viral src Oncogene

1987 • 405 citations

A target for Src in mitosis

1994 • 361 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

1996 • 285 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

1992 • 271 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

1987 • 253 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Requirement for Src Family Protein Tyrosine Kinases in G ₂ for Fibroblast Cell Division

1995 • 249 citations

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

1987 • 236 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase

1996 • 229 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

Platelet‐derived Growth Factor

1995 • 200 citations

Tyrosine Phosphorylation of Connexin 43 by v-Src Is Mediated by SH2 and SH3 Domain Interactions

1997 • 187 citations

Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors

1995 • 186 citations

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.

1993 • 180 citations

Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin.

1994 • 168 citations

Characterization of cDNA clones for the human c-yes gene.

1987 • 147 citations

The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant.

1988 • 136 citations

Requirement for c-Src Catalytic Activity and the SH3 Domain in Platelet-derived Growth Factor BB and Epidermal Growth Factor Mitogenic Signaling

1996 • 135 citations

Fine structural mapping of a critical NH2-terminal region of p60src.

1985 • 129 citations

Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases

1998 • 120 citations

The chemotactic response to PDGF-BB: evidence of a role for Ras.

1995 • 116 citations

Full Activation of the Platelet-derived Growth Factor β-Receptor Kinase Involves Multiple Events

1998 • 113 citations

Isolation and Oncogenic Potential of a Novel Human src-Like Gene

1986 • 113 citations

p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells

1995 • 112 citations

Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle.

1993 • 109 citations

Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling

1997 • 103 citations

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

1993 • 90 citations

Src interacts with dynamin and synapsin in neuronal cells

1998 • 89 citations

A Role for Src in Signal Relay by the Platelet-derived Growth Factor α Receptor

1998 • 88 citations

Identification of the Receptor-associated Signaling Enzymes That Are Required for Platelet-derived Growth Factor-AA-dependent Chemotaxis and DNA Synthesis

1999 • 87 citations

Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.

1992 • 87 citations

Requirement of phosphatidylinositol-3 kinase modification for its association with p60src.

1991 • 85 citations

Phosphorylation of serine 59 of p56lck in activated T cells.

1993 • 85 citations

Structure, expression, and chromosomal location of the human c-fgr gene.

1986 • 81 citations

The SH3 Domain of Bruton's Tyrosine Kinase Interacts with Vav, Sam68 and EWS

1997 • 76 citations

Isolation and oncogenic potential of a novel human src-like gene.

1986 • 69 citations

STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation

1999 • 64 citations

Activation of Src Family Members Is Not Required for the Platelet-Derived Growth Factor β Receptor To Initiate Mitogenesis

1998 • 57 citations

Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

1995 • 55 citations

A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues.

1993 • 54 citations

PDGF α-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells

1998 • 40 citations

Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -independent pathways.

1994 • 38 citations

Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells.

1996 • 30 citations

Activation of pp60c-src is necessary for human vascular smooth muscle cell migration

1997 • 26 citations

Excess early signaling activity inhibits cellular chemotaxis toward PDGF-BB.

1994 • 25 citations