The chemotactic response to PDGF-BB: evidence of a role for Ras.

Oncogenes and signal transduction

1991 • 2,816 citations

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

1962 • 2,726 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Chemotaxis in Eukaryotic Cells: A Focus on Leukocytes and Dictyostelium

1988 • 623 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.

1981 • 506 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

1994 • 414 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.

1992 • 317 citations

Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells.

1990 • 316 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine

1991 • 294 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.

1991 • 211 citations

Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.

1994 • 199 citations

Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2

1993 • 192 citations

Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.

1989 • 191 citations

Requirement of the Drosophila raf homologue for torso function

1989 • 181 citations

The biochemistry of ras p21

1991 • 176 citations

Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21^ras

1993 • 176 citations

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

1994 • 175 citations

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

1989 • 137 citations

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.

1993 • 121 citations

Alteration of the chemotactic response of NIH/3T3 cells to PDGF by growth factors, transformation, and tumor promoters

1984 • 120 citations

Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.

1993 • 101 citations

Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes.

1991 • 94 citations

Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

1993 • 70 citations

Dominant Inhibitory Mutations in the Mg²⁺-Binding Site of Ras^H Prevent Its Activation by GTP

1991 • 68 citations

Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene.

1987 • 63 citations

Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media.

1986 • 62 citations

The regulation of endothelial cell motility by p21 ras.

1994 • 58 citations

Effect of a Dominant Inhibitory Ha-ras Mutation on Neuronal Differentiation of PC12 Cells

1990 • 58 citations

A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

1991 • 57 citations

Interference with endogenous ras function inhibits cellular responses to wounding.

1993 • 48 citations

P21 v-ras Inhibits Induction of c-myc and c-fos Expression by Platelet-Derived Growth Factor

1988 • 47 citations

Effect of a Dominant Inhibitory Ha-ras Mutation on Mitogenic Signal Transduction in NIH 3T3 Cells

1990 • 42 citations

Rat plasma fibronectin contains two distinct chemotactic domains for fibroblastic cells

1991 • 32 citations

Raf‐1 is not a major upstream regulator of MAP kinases in rat fibroblasts

1993 • 29 citations

Excess early signaling activity inhibits cellular chemotaxis toward PDGF-BB.

1994 • 25 citations

Growth Factor Requirements of Oncogene-Transformed NIH 3T3 and BALB/c 3T3 Cells Cultured in Defined Media

1986 • 19 citations

Involvement of protein kinase C in signal transduction during fibroblast chemotaxis to platelet-derived growth factor and a fragment of fibronectin.

1989 • 16 citations