Overactivation of Phospholipase C-γ1 Renders Platelet-derived Growth Factor β-Receptor-expressing Cells Independent of the Phosphatidylinositol 3-Kinase Pathway for Chemotaxis

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

1995 • 472 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 330 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.

1990 • 263 citations

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

1997 • 251 citations

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling

1998 • 218 citations

Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.

1991 • 207 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells.

1993 • 158 citations

The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C

1997 • 133 citations

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

1996 • 123 citations

Requirement for Phospholipase C-γ1 Enzymatic Activity in Growth Factor-Induced Mitogenesis

1998 • 100 citations

Identification of the Major Phosphorylation Sites for Protein Kinase C in Kit/Stem Cell Factor Receptor in Vitro and in Intact Cells

1995 • 99 citations

In Vitro Tyrosine Phosphorylation of PLC-γ1 and PLC-γ2 by SRC-Family Protein Tyrosine Kinases

1993 • 89 citations

Efficient Incorporation of Anti-HIV Deoxynucleotides by Recombinant Yeast Mitochondrial DNA Polymerase

1995 • 73 citations

An SH3 domain is required for the mitogenic activity of microinjected phospholipase C‐γ1

1995 • 70 citations

Phospholipase C-gamma 1 associates with viral and cellular src kinases

1993 • 69 citations

Phosphatidylinositol 3-Kinase-independent Signal Transduction Pathway for Platelet-derived Growth Factor-induced Chemotaxis

1996 • 65 citations

Demonstration of Functionally Different Interactions between Phospholipase C-γ and the Two Types of Platelet-derived Growth Factor Receptors

1995 • 55 citations

PLCγ1 Src Homology Domain Induces Mitogenesis in Quiescent NIH 3T3 Fibroblasts

1996 • 33 citations

Leukocyte chemoattraction by 1,2-diacylglycerol.

1988 • 30 citations

Excess early signaling activity inhibits cellular chemotaxis toward PDGF-BB.

1994 • 25 citations

Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022

1993 • 20 citations