Physiological and pathophysiological roles of nitric oxide

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

1991 • 1,136 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Regulators of Angiogenesis

1991 • 959 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

The biology of nitrogen oxides in the airways.

1994 • 928 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Control of vascular permeability by polymorphonuclear leukocytes in inflammation

1981 • 850 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.

1993 • 707 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages

1983 • 689 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Modulation of acute inflammation by endogenous nitric oxide

1992 • 543 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity.

1992 • 457 citations

L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.

1991 • 450 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Aminoguanidine selectively inhibits inducible nitric oxide synthase

1993 • 412 citations

Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide.

1994 • 396 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

1992 • 378 citations

Ramiprilat enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin.

1991 • 361 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

1992 • 343 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Nitric oxide prevents leukocyte adherence: role of superoxide

1993 • 331 citations

Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.

1991 • 331 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

1992 • 299 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing.

1992 • 279 citations

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms.

1986 • 272 citations

Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells

1994 • 263 citations

Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

1993 • 260 citations

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1991 • 257 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

Understanding the controversy over the identity of EDRF

1994 • 248 citations

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

1990 • 244 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension

1992 • 238 citations

Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion.

1992 • 234 citations

The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa

1993 • 202 citations

Evidence that endogenous nitric oxide modulates oedema formation induced by substance P

1990 • 201 citations

Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury.

1993 • 198 citations

Angiotensin-converting enzyme inhibition improves cardiac function. Role of bradykinin.

1994 • 185 citations

Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size

1992 • 184 citations

Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature

1992 • 179 citations

Role of nitric oxide in reactive hyperemia of the guinea pig heart.

1992 • 174 citations

Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing.

1993 • 173 citations

Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation.

1992 • 172 citations

Evidence that nitric oxide is an endogenous antiangiogenic mediator

1994 • 170 citations

Inhibition by nitric oxide‐donors of human polymorphonuclear leucocyte functions

1993 • 161 citations

Inhibition of Nitric Oxide Limits Infarct Size in the in Situ Rabbit Heart

1993 • 160 citations

Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.

1993 • 143 citations

The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit

1991 • 136 citations

Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway

1991 • 135 citations

Therapeutic Angiogenesis

1993 • 132 citations

Endothelium‐derived relaxing factor is a nitrosyl iron complex with thiol ligands

1991 • 132 citations

Requirements for neutrophil products and L-arginine in ischemia-reperfusion injury.

1993 • 128 citations

Nitric Oxide Promotes DNA Synthesis and Cyclic GMP Formation in Endothelial Cells from Postcapillary Venules

1993 • 125 citations

Interferon-γ inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation

1992 • 121 citations

Chronic kinin receptor blockade attenuates the antihypertensive effect of ramipril.

1992 • 107 citations

Nitric oxide is involved in the regulation of angiogenesis

1993 • 105 citations

Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro.

1993 • 100 citations

Synergistic inhibition of platelet aggregation by endothelium derived relaxing factor and prostacyclin

1988 • 99 citations

Role of endothelium-derived nitric oxide in myocardial reactive hyperemia

1992 • 97 citations

Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro

1993 • 95 citations

Support of renal blood flow after ischaemic‐reperfusion injury by endogenous formation of nitric oxide and of cyclo‐oxygenase vasodilator metabolites

1993 • 91 citations

Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase.

1993 • 82 citations

The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro

1993 • 75 citations

Nitric oxide-induced microvascular permeability alterations: a regulatory role for cGMP

1993 • 68 citations

Physiological release of nitric oxide is dependent on the level of vascular tone

1990 • 65 citations

Synergism between interleukin-1ß and interferon-γ, an inducer of nitric oxide synthase, in rat lung fibroblasts

1992 • 62 citations

The Activated Keratinocyte

1990 • 53 citations

Nitric oxide synthase inhibitors improve skin flap survival in the rat

1994 • 52 citations

The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart

1991 • 46 citations

Effect of nitric oxide on mitogenesis and proliferation of cerebellar glial cells

1992 • 45 citations

Nitric oxide-mediated, endothelium-dependent vasodilation is selectively attenuated in the postischemic extremity.

1993 • 38 citations

Vascular relaxation mediated by hydroxylamines and oximes: Their conversion to nitrites and mechanism of endothelium dependent vascular relaxation

1989 • 38 citations

Nitric oxide synthase inhibitor, nitro‐iminoethyl‐L‐ornithine, reduces ischemia‐reperfusion injury in rabbit skeletal muscle

1994 • 35 citations

Antisense oligodeoxynucleotide to inducible nitric oxide synthase inhibits nitric oxide synthesis in rat pulmonary artery smooth muscle cells in culture.

1993 • 33 citations

Influence of nitric oxide on agonist-mediated calcium mobilization in platelets

1990 • 32 citations

The local modulation of vascular permeability by endothelial cell derived products

1988 • 27 citations

Impaired vasodilatation of epicardial coronary arteries and resistance vessels following myocardial ischemia and reperfusion in anesthetized dogs

1990 • 27 citations

Production of endothelium-derived relaxing factor (EDRF) is compromised after ischemia and reperfusion

1993 • 22 citations

Inhibition of Platelet Activating Factor-Induced Platelet Aggregation by Molsidomine, SIN-1, and Nitrates in vitro and ex vivo

1989 • 19 citations

Inhibition of Platelet Activating Factor-Induced Platelet Aggregation by Molsidomine, SIN-1, and Nitrates in vitro and ex vivo

1989 • 18 citations

Biological Properties of Platelet-Activating Factor

1994 • 10 citations

Nitrite is produced by elicited but not by circulating neutrophils

1993 • 9 citations

Nitric oxide and superoxide in cultured cells: limited production and influence on DNA synthesis

1993 • 8 citations

Interferon-gamma increases cytoplasmic motility of alveolar macrophages via nitric oxide-dependent signaling pathways.

1994 • 6 citations